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Abuse-Deterrent Studies for Controlled Drugs - A Changing Landscape

Prescription drug abuse is the Nation's fastest-growing drug problem and has been classified as an epidemic by the Centers for Disease Control and Prevention.1 Abuse in this case can be defined as intentional misuse of prescription pharmaceuticals to obtain a desirable physiological or physical effect. Prescription drug abuse is the second most abused category of drugs after marijuana,2 and the abuse of opioid painkillers, primarily oxycodone, hydrocodone and oxymorphone, has become the largest component of prescription drug abuse in the United States. These drugs have typically been abused by chewing, crushing a tablet into a fine powder before snorting it, or dissolving a crushed powder in water before IV injection.

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