Purity determination of pharmaceuticals by thermal analysis

Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis technique. A well-established application is the purity determination of organic substances. The method is based on the van’t Hoff law of melting point depression of eutectic systems. Purities between 90 and 100 mol% can be reliably determined. Purity determination is used in the chemical and pharmaceutical industries and also for additives in the food and plastics industries.
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