The pandemic was a unique time in our industry where there was a perfect storm of need, money, collaboration, and trial patients all available in abundance. There was an atmosphere of all hands, and resources, on deck in the race to a COVID-19 vaccine.
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Life science companies face major obstacles to continue operations and profitability. Examples include patent expirations, low research and development productivity, increased competition, decreased margins, non-optimized processes and mounting compliance pressure.
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Sysmex
Multiparameter flow cytometry has become an integral tool in the workup of abnormal WBC findings, allowing for rapid and accurate identification of abnormal cell populations, cell lineage assignment, and assessment of clonality. This presentation will discuss a series of cases that demonstrate the utility of flow cytometry in the diagnostic workup of hematologic disorders presenting with abnormal WBC differential and incorporation of relevant criteria from the revised WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues.
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The analysis of Host Cell Proteins (HCPs) has historically been performed using ELISA-based tests. A number of off-the-shelf products (e.g. Cygnus kits) are available and the testing is relatively straightforward. However, it been recognized for some time that these kits generally allow detection of a maximum of ~70% of the HCPs present in biopharmaceutical products. This is due to the fact that in any anti-HCP antibody pool, there won’t be antibodies available to cover the entire spectrum of HCP species present.
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