Complementary Detection of Somatic Variants from Tumor Tissue and Plasma Samples Using AVENIO Analysis Kits

Antibody-Drug Conjugates (ADCs) are a rapidly growing class of oncology therapeutics wherein a potent cytotoxic drug is conjugated to the antibody molecule. The impact of drug conjugation on the antibody's conformation needs to be evaluated.

With the continued pressure to reduce costs through innovations and efficiencies all while delivering faster sample results, the use of an On-line Water Bioburden Analyzer (OWBA) is one way companies can meet these demands. OWBA technology has the flexibility to be used for purified water, water for injections or even cleaning verifications and provides real time microbial detection as an early warning for system health. The benefits for using an OWBA include the potential for energy savings through reduced loop sanitation, labor cost reduction and improved product quality and process understanding.

While the importance of ligand-receptor binding kinetics on drug action is becoming well established, focus to date has been almost entirely on the role of the dissociation constant on drug efficacy and duration of action.

The Pharmaceutical Industry has a strong need to develop knowledge from data. Although the latter is not at a premium in the Pharmaceutical Industry the former is, as always, at a premium. Multivariate data analysis (MVA) is a set of statistical data analytical methods which has been widely adopted within the Pharmaceutical Industry, and it has pre-eminence within the discipline.