New insights into large genomes

October 18, 2017

Since Haemophilus influenzae became the first organism to have its entire genome sequenced in 19951 , there are now thousands of completed genomes covering archaea, bacteria and eukarya. However, the term ‘completed genome’ (or sometimes ‘finished genome’) is overused, as the majority of sequenced genomes contain numerous gaps. These gaps correspond to repetitive regions and structural variants that are too large to be resolved by the short-read sequencing technologies often used to generate the genomes. This review outlines how researchers are now utilizing the advantages of nanopore long-read sequencing to address this challenge, delivering more accurate large genomes for a wide variety of applications.

Spotlight

Ocular Therapeutix, Inc.

Founded in 2006, Ocular Therapeutix is a fast-growing, aspiring leader in the biopharmaceutical industry. The company has a clear vision – to improve current therapeutic options in ophthalmology by encapsulating previously approved .

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