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. https://pharmaceutical.report/Resources/Whitepapers/67291945-3768-470b-b347-ad1ce4b5fc2d_Lubrizol_Whitepaper (1).pdf
whitepaper
HOT MELT EXTRUSION FOR ORAL SOLID DOSAGE FORMS
Approximately half of all marketed drugs are administered orally, mostly in solid forms such as tablets or capsules. However, many APIs suffer from poor water solubility which leads to slow dissolution rates in the gastrointestinal tract and poor oral bioavailability. Hot melt extrusion is an efficient, trusted, and scalable tool that improves solubility and enables the development of oral solid dosage forms from BCS Class II and IV compounds. DOWNLOAD