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. https://pharmaceutical.report/Resources/Whitepapers/3700df81-b1ee-43f8-a486-dc3820720de5_Efficient-Removal-of-Aggregates.pdf
whitepaper
SHARESHARESHARE
EFFICIENT REMOVAL OF AGGREGATES FROM MONOCLONAL ANTIBODIES
Monoclonal antibody (mAb) therapeutics have been widely used to treat various diseases, including cancer. Oftentimes, dimers and other high molecular weight aggregates are present in the mAb therapeutics, leading to reduced biological activity. Traditionally-used methods for aggregate removal rely heavily on anion exchange chromatography (AEX) in flow-through mode followed by a generic bind/elute polishing step. DOWNLOAD