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. https://pharmaceutical.report/Resources/Whitepapers/82a3360c-784b-4965-872c-3521f25236bf_Whitepaper-Feb-2018-Effect-of-Extrusion-Parameters_0.pdf
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ANALYSIS USING COUNTER-ROTATING TWIN SCREW EXTRUDER
While the co-rotating, intermeshing TSE is more commonly used in pharmaceutical R&D and production, the counter-rotating, intermeshing TSE is a viable tool to successfully process these formulations. Energy input must be strategically balanced to perform mixing functions without degradation of API. Changes of screw rpm, temperature, residence time, residence time distribution, and feed rate all played roles in both degradation and solubility. DOWNLOAD