Almirall takes option on Dermira’s eczema drug lebrikizumab

pharmaphorum | June 25, 2019

Spain’s Almirall has taken an option granting rights to develop and market Dermira’s eczema drug lebrikizumab in Europe, in a bid to take on Sanofi/Regeneron’s recently approved Dupixent. The companies had struck an option and license agreement in February which granted Almirall European rights to the drug in atopic dermatitis, also known as eczema, and certain other indications.
Barcelona-based Almirall paid $30 million up front to Dermira and will pay a further $50 million now that it has exercised the option. Dermira will receive further payments if certain goals are met, including $30 million for beginning certain phase 3 clinical trials, and up to $85 million upon completing certain regulatory milestones and the first commercial sale in Europe. Almirall took the decision after topline results reported by Dermira from a phase 2b dose-ranging study showed that all three doses of lebrikizumab met the trial’s primary goal. The drug, which inhibits interleukin (IL)-13, showed dose-dependent improvements across a range of measures in patients, such as itch and skin inflammation, in patients with moderate-to-severe disease when compared with placebo. Almirall thinks that the results suggest that lebrikizumab has the potential to outperform already marketed drugs such as Sanofi and Regeneron’s recently approved Dupixent (dupilumab), which is tipped to become a blockbuster after approval in eczema and asthma.

Spotlight

There aren't too many people in healthcare who can say they've worked for both a Big Pharma company AND a hot health tech startup, so we're lucky we had a chance to talk with Kristin Millburn, who is now sharing her expertise as Global Head for Digital Health Partnerships at Healthware. From her years at Novartis, to her time with mindfulness startup, Headspace, Kristin has learned a lot that digital therapeutics startups might find useful as they attempt to bridge the gap between traditional healthcare companies and the growing base of well-informed healthcare consumers. What does Kristin predict will happen in the digital therapeutics space in the next 3-5 years? "Partnerships" might be the most important word in Kristin's new title.


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Orbit Discovery and WuXi AppTec Sign Agreement to Access Peptide Discovery and Optimisation Technologies

Orbit Discovery | March 08, 2022

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VIEWS AND ANALYSIS

CHMP Recommends Approval of Dupixent® (dupilumab) for Children Aged 6 to 11 Years with Severe Asthma with Type 2 Inflammation

Regeneron Pharmaceuticals, Inc | January 31, 2022

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PHARMA TECH

CSL Limited announces tender offer to acquire Vifor Pharma Ltd

Vifor Pharma Group | December 15, 2021

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PHARMACY MARKET

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BioMatrix Specialty Pharmacy | February 09, 2022

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Spotlight

There aren't too many people in healthcare who can say they've worked for both a Big Pharma company AND a hot health tech startup, so we're lucky we had a chance to talk with Kristin Millburn, who is now sharing her expertise as Global Head for Digital Health Partnerships at Healthware. From her years at Novartis, to her time with mindfulness startup, Headspace, Kristin has learned a lot that digital therapeutics startups might find useful as they attempt to bridge the gap between traditional healthcare companies and the growing base of well-informed healthcare consumers. What does Kristin predict will happen in the digital therapeutics space in the next 3-5 years? "Partnerships" might be the most important word in Kristin's new title.

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