Precision medicine is an emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle. The Precision Medicine Initiative will generate the scientific evidence needed to move the concept of precision medicine into clinical practice. Create a research cohort of > 1 million American volunteers who will share genetic data, biological samples, and diet/lifestyle information, all linked to their electronic health records if they choose. Pioneer a new model for doing science that emphasizes engaged participants, responsible data sharing, and privacy protection.