The fully realized vision of precision medicine includes the capability to rapidly diagnose, sequence and develop a personalized treatment plan based on combined analysis of genotype, phenotype, environmental, clinical and behavioral data. Precision medicine can be advanced through the “All of Us” research initiative of the Precision Medicine Initiative, the most ambitious accumulation of human genomic, personal health and clinical information in history; but accelerating precision medicine to achieve this vision will require new capabilities and speed in personal health, clinical and genomic data storage transfer and analysis, as well as in interoperability and security. Further, precision medicine will demand new private sector, legislative and regulatory approaches for review and approval of genomic sequencing technologies and other software and devices needed to advance knowledge of disease factors that demonstrate variability among individuals.