UNDERSTANDING THE PROPENSITY OF SEQUENCE VARIANTS DURING CELL LINE AND CULTURE PROCESS DEVELOPMENT

Sequence variants (SVs) are protein isoforms that contain one or more unintended amino acid substitutions. They can arise at a single amino acid site due to a genetic (RNA/DNA) mutation or at multiple amino acid locations, potentially due to translational errors, also referred to as misincorporations. The ability to detect SVs in protein biotherapeutics is critical due to their potential impact on structural/functional characteristics, safety, and efficacy. Trypsin peptide mapping with liquid chromatography-ultrahigh resolution tandem mass spectrometry (LC-MS/MS) provides the ideal workflow for the detection, identification, and relative quantitation of both genetic and translational SVs. 
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OTHER ON-DEMAND WEBINARS

Cell Biology 2017

labroots

Join us in advancing basic biology and recent tools and techniques in cell research by coming together with like-minded colleagues. Cell Biology 2017 creates a valuable platform for inspiring global and interdisciplinary collaboration in a virtual environment. The Conference will bring together professors, post-docs, biologists and biomedical professionals from all over the world. Attend interactive sessions, first-class exhibitions and virtual poster presentations. A cell is the smallest individual unit of any living organism. Cell biology studies cells – their physiological properties, structure, the organelles they contain, environmental interactions, life cycle, division and death, on a microscopic and molecular level.
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MAT: a powerful tool to assess pyrogenic risk in pharmaceutical process

sigmaaldrich

Microbial risk in pharmaceutical process is not limited to living microorganisms and intact microbial cells. Subcellular components from microorganisms remaining from the production process can be source of pyrogens, compromising product quality and patient safety as these substances are not eliminated by classical filtration or sterilization steps.
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Integrated pharma manufacturing – It works

europeanpharmaceuticalreview

This webinar focuses on the benefits of integrated pharma manufacturing using examples of integrated processing and packaging solutions. The webinar also highlights the key advantages of choosing a single pharma solutions provider for all manufacturing needs.
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The Future of Real-World Evidence: Pharma’s Next Moves

Throughout the pharma industry, real-world evidence (RWE) is leveraged across organizations for key decision-making within a therapy’s life cycle — from R&D to new US Food and Drug Administration (FDA) drug submissions to commercial strategy operations.
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