Revolutionizing the Modern Trial Strategy

This series will provide you with tools to critically process and analyze medical scientific literature. You will get a good understanding of basic statistical concepts and theory that enable you to explain, understand and interpret data. These Webinars are practical and based on published articles and the analysis of these.

Discover how you can easily meet upcoming national regulations on serialization of drugs to ensure patient safety

Enabling formulations becomes more and more necessary to obtain adequate exposure of APIs during (pre)-clinical research. Currently, most registered formulations to improve bioavailability are based on lipidic systems, which make use of intrinsic digestion processes within the GI tract, facilitating the absorption of APIs. Aside from a general absorption mechanism, lipidic systems can also promote lymphatic transport of poorly soluble drugs, such as hormones. In addition, many different indications, such as HIV therapy, oncology, immunosuppressant and even arising therapies related to medicinal cannabis (e.g. CBD) can benefit from lipid formulations. These formulations create multiple possibilities for oral administration because they can be manufactured as solutions, suspensions, emulsions, and self-(micro)emulsifying systems.

This webinar will focus on the advantages of nasal powder formulations and on a non-human primate (NHP) model to quantify nose-to-brain delivery of a model compound, sumatriptan. The webinar will also compare pharmacokinetic advantages of nasal powders versus aqueous formulations, as well as in vitro results of nasal powder delivery.