Optimal Capsule Selection for your Pharma and Nutra Products

Current drug development strategies are very expensive and lead to high drug attrition rates. One major reason for low success rates is the lack of predictive preclinical models for efficacy testing. The availability of induced pluripotent stem cell (hiPSC) technologies holds great promise to bring human biology to drug discovery but is still compromised by problems related to scalability, biological relevance, robustness and costs.

The field of immuno-oncology has exploded in the clinic, in the press, and on Wall Street, particularly regarding the use of genetically modified immune cells to fight cancer. This “explosion” is largely due to the success of chimeric antigen receptor (CAR) T-cell therapy. The fields of immunology and gene therapy have converged to harness recombinant viruses to deliver “living drugs” with remarkable clinical efficacy, especially for patients with blood cancers. Multiple approaches to engineering immune cells mostly T cells but also other immune cell types make use of CARs, while tumor-specific T-cell receptors continue to gain a foothold in the field, mostly for the treatment of solid tumors. Several genome-editing approaches are now available, including established technologies such as zinc-finger nucleases, and newer modalities like the CRISPR/Cas9 system. These methodologies have recently been applied to augment the antitumor efficacy of adoptively transferred cells in the clinic by knocking out negative regulatory molecules such as PD1.

Individuals take for granted everyday interactions with well-designed products and devices that save both time and aggravation. Well-designed products can eliminate overall confusion for the user. Every day, more medical devices are designed for portability and at home monitoring. A major initiative in the medical device industry is to reduce the workload on our already overworked medical professionals. Medical device manufacturers must consider countless items when designing and manufacturing their final product, but unfortunately, connectors usually take a back seat to other more engaging topics. Nicomatic has relationships with many of the top medical device manufacturers to help them determine the best connector solution for their specific application. In the medical market, connectors are unique to their specific application and one solution does not work across the board.

Pharmaceutical manufacturers often have the task of reducing waste to meet company expectations, document the process to meet regulatory requirements and improve quality to meet customer specifications. Let's be honest, not achieving any of the above points is not an option in most pharmaceutical companies. That's where the capacity analysis comes into play.