Increasing Efficiency in the Pharma Analytical Workflow through Standards and Reference Materials

Recently investigators have begun to harness new technology such as microfluidic modulation spectroscopy (MMS) to reveal protein structural changes, as a solid understanding of structure and function is extremely important to the effectiveness of biotherapeutic drugs and scientist today are challenged in gathering a complete understanding with current tools. During the biomanufacturing process, proteins such as antibodies, often undergo conformational changes that can alter their secondary structure, leading to critical variations in their overall function. These changes have been historically difficult to detect, as traditional analytical techniques are not great at detecting small differences in protein structure.

Psychedelic-class drugs like psilocybin, ketamine and MDMA are powerful probes of conscious states with tremendous promise for an array of psychiatric conditions. Each compound has a unique set of effects, some desirable and others less-so, often dependent on the setting in which they are given.

The COVID crisis has revealed the importance of rapid and optimized equipment design and scale up for drug and vaccine manufacturing processing as well as the necessity to maintain an optimal productivity level throughout the equipment lifecycle.

Therapeutic approaches for Parkinson’s disease are either focused on disease modification (a-synuclein or MPTP models) or symptom management (haloperidol or 6-OHDA models). Therapeutic approaches for Parkinson’s disease are either focused on disease modification (a-synuclein or MPTP models) or symptom management (haloperidol or 6-OHDA models). Our scientists have validated available PD models for changes in fine motor skills, L-dopa-induced dyskinesias, drug-induced jaw movements, and non-motor endpoints such as cognition, constipation, and EDS. Additionally, we have also tested dopamine and other neurotransmitter levels in brain compartments of rodent and large animal models via microdialysis sampling.