Identifying Novel Therapeutic Approaches and Predictive Biomarkers for Castleman Disease

This webinar addresses the requirements for continuous monitoring of water for injection (WFI) systems and how this can be achieved with total organic carbon (TOC) and conductivity. It will also cover cold WFI production according to EP and how it applies to water systems.

This webinar will focus on the benefits of spray-drying in addressing the solubility challenge, detailing how simple, scaleable systems can be quickly developed to provide drug products for clinical evaluation. Approaches for transitioning spray-dried dispersions to formulated solid oral dosage forms for downstream development will also be described.

The pill-taking experience has a direct impact on patient acceptance and adherence to a prescription regimen; which in turn can impact a drug’s overall effectiveness. Patients that report having difficulty swallowing tablets are far more likely to skip, discontinue, or delay a dose. Every missed dose means non-compliance, and non-repeated (non-refilled perscriptions equate to lost revenue for pharmaceutical manufacturers and avoidable for costs for healthcare systems. In this webcast, we will unmask influences that contribute to patient non-adherence and the factors that impact how people feel about the swallowability of tablets.

Hot Melt Extrusion (HME) is an established processing technology that can be used for the development of paediatric formulations. The processing of lipids via HME has been proved ideal for high drug loaded dosage forms with sustained release of drugs. The study investigates the effect of the lipid type and the food grade on the dissolution rates of extruded pellets or extemporaneous formulations.