Deciphering fibrosis: Exploring the biological drivers of fibrotic disease in the liver and heart

Fibrotic diseases of the heart and liver impact a significant portion of the global population and are a growing public health concern. Fibrosis occurs when fibroblasts deposit excess extracellular material within the tissue in response to certain stimuli or injury. Myocardial fibrosis is associated with nearly all forms of heart disease. The pathological changes that can result from fibrosis include cardiomyocyte hypertrophy, chamber dilation, heart valve stiffening, and others, all of which contribute to heart failure. Nonalcoholic steatohepatitis (NASH) is a fatty liver disease characterized by hepatocyte inflammation that contributes to fibrosis, cirrhosis, and liver failure. NASH is closely linked to obesity and diabetes; changes in diet have thus contributed to its expansion and impact across the globe. Understanding the underlying biology of fibrosis is critical for the diagnosis, treatment, and management of cardiac fibrosis, NASH, and other fibrotic diseases.
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Spotlight

OTHER ON-DEMAND WEBINARS

Ensuring Integrity of Drug Formulation from Development to QC

pharmtech

After a small molecule has been identified as a viable drug candidate, substantial testing is required to assure that chemical and structural integrity are preserved throughout the drug development process to maintain its functionality. To keep a balance between quality and manufacturability, time-consuming and labor-intensive testing and analysis are required to demonstrate that chemical integrity is intact. Among the techniques used to study changes in chemical integrity are infrared and Raman spectroscopy. This webcast will discuss where efficiencies can be made in data collection, regulatory compliance, instrument qualification, method validation, and data integrity all along the development pipeline up to final quality control (QC) testing. Learn how to quickly identify changes in polymorphic structure, monitor API to excipient distribution, and troubleshoot out-of-specification (OOS) product lots, while preserving data integrity needed for audits.
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Use of Cannabis in Medicine - Drug or Drug?

MedCram

In the webinar, Prof. Kirsten Müller-Vahl gives an overview of the use of cannabis in medicine, explains the basics of the endocannabinoid system and introduces the various cannabis compounds - from different cannabis flowers to cannabis-based drugs based on extracts and synthetic cannabinoids.
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Preventing Readmissions Through Quality Healthcare

Lorman Education Services

Gain a better understanding of quality health care and improved patient outcomes based on the quality of care. Health care is quickly becoming a commodity. The increased focus on quality by CMS and other payer sources has driven the need to create effective strategies to control costs. One such strategy is reducing preventable readmissions. Hospitals are keenly aware of the cost of readmissions, both in penalties from CMS and in their reputation as centers for quality and improved patient outcomes. The purpose of this information is to equip the user with the tools to identify those patients at risk, to intervene when necessary, to disseminate to their staff, and to ensure that lasting change will occur. This information is an intermediate level course designed for mid to upper-level hospital administrators. This course is ideal for the hands-on manager to assess and implement a hospital-wide program aimed at reducing the number of readmissions.
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Validating Configurable Interactive Response Technology Solutions for Clinical Studies

Bioclinica

In this webinar, the validation of an interactive response technology (IRT) solution built with configurable parameters will be explored. Traditionally, interactive response technology solutions require validation of each study-specific requirement to ensure proper implementation. With the prevalence of configurable interactive response technology solutions where the validation of each configurable parameter occurs within the product, the need for full validation of each requirement within a clinical study has lessened. This webinar will explore how to take advantage of configurations and how to verify them, thereby reducing the effort and timeline required for validation while still maintaining quality within each study.
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