American Association for the Advancement of Science
Fibrotic diseases of the heart and liver impact a significant portion of the global population and are a growing public health concern. Fibrosis occurs when fibroblasts deposit excess extracellular material within the tissue in response to certain stimuli or injury. Myocardial fibrosis is associated with nearly all forms of heart disease. The pathological changes that can result from fibrosis include cardiomyocyte hypertrophy, chamber dilation, heart valve stiffening, and others, all of which contribute to heart failure. Nonalcoholic steatohepatitis (NASH) is a fatty liver disease characterized by hepatocyte inflammation that contributes to fibrosis, cirrhosis, and liver failure. NASH is closely linked to obesity and diabetes; changes in diet have thus contributed to its expansion and impact across the globe. Understanding the underlying biology of fibrosis is critical for the diagnosis, treatment, and management of cardiac fibrosis, NASH, and other fibrotic diseases.
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Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Formulation in a lipid-based carrier can be a feasible approach, but usually requires extensive testing to find suitable excipient combination.
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ON24
Historically, distillation has been the most common technology used to produce Water for Injection (WFI), due to prior process advantages and historical regulatory requirements. Changes in the European Pharmacopeiano longer require the use of distillation systems to produce WFI. In this webcast, learn about the impact of this regulatory change on water system design and how reverse osmosis and ultrafiltration can be used to produce WFI with significant lifecycle cost advantages.
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Abcam plc
What makes a good potential target for drug discovery? Listen in as Dr. Elizabeth Glennon, of King's College London, discusses how the disruption of axonal transports early on within Alzheimer's Disease provides excellent targets for drug discovery. How the disruption of axonal transport contributes to the development of Alzheimer's disease. Mechanisms of axonal transport of the Alzheimer's amyloid precursor protein, and how these are altered in the disease.
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