Antibodies and Antibody-Drug Conjugate Higher Order Structures Revealed

Recently investigators have begun to harness new technology such as microfluidic modulation spectroscopy (MMS) to reveal protein structural changes, as a solid understanding of structure and function is extremely important to the effectiveness of biotherapeutic drugs and scientist today are challenged in gathering a complete understanding with current tools. During the biomanufacturing process, proteins such as antibodies, often undergo conformational changes that can alter their secondary structure, leading to critical variations in their overall function. These changes have been historically difficult to detect, as traditional analytical techniques are not great at detecting small differences in protein structure.
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Spotlight

OTHER ON-DEMAND WEBINARS

Combating Drug Diversion and Counterfeiting in a Post-Serialization Landscape

systechone

In this 45-minute webinar, industry experts discuss the dangers of stopping at compliance and explore the opportunities to maximize your serialization investment for true supply chain security.
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New drugs for the old enemy

Despite the efforts towards malaria eradication, the latest estimates show that the number of cases is rising and malaria continues to have a devastating impact on the most vulnerable populations.
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BPOG RISK-BASED APPROACHES TO USE OF CLOSED SYSTEMS IN RENOVATIONS OF EXISTING BIOPHARMA API FACILITIES

Bio Pharma Asia

Companies often experience regulatory challenges during an inspection of aging facilities, requiring them to initiate projects to optimize product protection and updating to current standards for classified areas for biopharma manufacturing. For a long time, the company response has been to improve the existing classified areas or maybe even upgrading to a higher grade of classification. However, it may be more appropriate, and improve product protection, to instead implement the use of closed system processes and downgrade room classification during these facility renovation projects. If closed systems are fully utilized, then a CNC space can be used. As well as reducing the complexity of operations, this will reduce capital and operating costs.
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The Importance of Early Patient Involvement in Clinical Trial Design

Questexweb

Patient-centricity gets a lot of buzz, but what are the benefits of involving patients in the planning of a clinical trial?
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