Accelerate Cardio-metabolic Research Using Patient-Centered Technology

This webcast will describe the use of Raman spectroscopy techniques for improving the speed and efficiency of pharmaceutical testing. In the first of two presentations, transmission Raman is discussed as an alternative, non-destructive method for product release testing, working alongside HPLC to significantly reduce the costs and resources spent per content uniformity test. The second presentation focuses on the use of spatially offset Raman spectroscopy (SORS) for raw material testing through sealed opaque containers. Through-container testing removes the need for sampling—improving quality via increased or 100% ID testing, but with no additional resources required.

Therapeutic approaches for Parkinson’s disease are either focused on disease modification (a-synuclein or MPTP models) or symptom management (haloperidol or 6-OHDA models). Therapeutic approaches for Parkinson’s disease are either focused on disease modification (a-synuclein or MPTP models) or symptom management (haloperidol or 6-OHDA models). Our scientists have validated available PD models for changes in fine motor skills, L-dopa-induced dyskinesias, drug-induced jaw movements, and non-motor endpoints such as cognition, constipation, and EDS. Additionally, we have also tested dopamine and other neurotransmitter levels in brain compartments of rodent and large animal models via microdialysis sampling.

Low frequency Raman spectroscopy has been used to study various polymorphs and can be applied to the design of crystallization control strategy. Extending the low frequency spectral region to include the fingerprint region provides access to collective vibrations of molecules in the amorphous and crystalline states and yields valuable insight when differentiation of various forms is quintessential.

The composition of pharmaceutical tablets and the distribution of ingredients therein can be determined using chemical imaging by vibrational microscopy.