. home.aspx

NEWS

home.aspx
   


Researchers create ‘protocells’ for delivering drugs to deepest tumor regions

January 11, 2018 / news-medical.net
SHARESHARESHARE

Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics. One hurdle specific to treating solid tumors is a protective layer called an extracellular matrix that can prevent chemotherapeutic agents from penetrating the tumor's core. Scientists now report results in ACS' Chemistry of Materials showing that, by cloaking anti-cancer drugs in a specially designed particle, they could target and destroy tumor cells deep inside a malignant mass in vitro. For tumors that can't be extracted with surgery, radiation and chemotherapy are the treatments of choice, but both can involve serious side effects due to a lack of specificity: They'll kill healthy cells along with malignant ones. Researchers have long known that thanks to the unique blood vessel architecture surrounding tumors, nanoparticles can easily pass into the cancer zone, offering a potential route for the specific delivery of chemotherapies to ...