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AZ Imfinzi combo fails lung cancer study

August 21, 2019 / Anna Smith
SHARESHARESHARE

AstraZeneca has announced that its combination of Imfinzi durvalumab and tremelimumab has failed to hit its key target in a late-stage trial assessing its potential in patients with late-stage lung cancer. The drug giant reported that in the primary analysis population - patients with stage IV non-small cell lung cancer NSCLC whose blood TMB was 20 or more mutations per megabase - the combination did not meet the primary endpoint of improving overall survival (OS) compared to standard of care (SoC) chemotherapy. On the plus side, the safety and tolerability profile for the combination of Imfinzi and tremelimumab was consistent with previous trials and AstraZeneca is set to submit the full results for presentation at a forthcoming medical meeting. José Baselga, executive vice president, Oncology R&D said that the company are “fully committed to a deep analysis of the vast clinical and biomarker data from this trial to gain further insights to improve Immuno-Oncology app...