AbbVie suffers fresh setback with lung cancer drug Rova-T

AbbVie has suffered a further setback with its oncology drug Rova-T after early data from a lung cancer trial suggested that patients were living longer when treated with standard therapy. The company is looking for new blockbusters to bring in new revenues as its big-selling Humira (adalimumab) has already lost patent protection in Europe, and will face competition from cheaper biosimilars in the US in 2023. But it doesn’t look like Rova-T fits the bill. AbbVie spent $5.8 billion buying Rova-T’s developer Stemcentrx in 2016, and it seems that the gamble has not paid off.
AbbVie is testing the drug in first, second and third line small cell lung cancer, and results from the phase 3 trial in the third line advanced small cell lung cancer (SCLC) already disappointed in March when AbbVie said they did not support a fast-track review by the FDA. Now AbbVie has said it will halt enrolment to the phase 3 TAHOE study in the second line advanced SCLC on the advice of its independent data monitoring committee.
The committee conducted an interim analysis and found that overall survival in patients treated with the drug, full name rovalpituzumab serine, was shorter compared with the standard care topotecan control arm. The committee recommended investigators and patients make an individual decision whether to stay on Rova-T treatment based on their response.