Hospital Medicine & Internal Medicine

December 12, 2022 | 7:30PM EST | USA

Hospital Medicine
Appraise the symptoms of congestive heart failure and detect the common causes of systolic heart failure.
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Spotlight

Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following sleep deprivation are unknown. Moreover, it remains unclear whether ecologically modest night-to-night changes in sleep, within an individual, confer consequential day-to-day changes in experienced pain. Here, we demonstrate that acute sleep-deprivation amplifies pain reactivity within human (male and female) primary somatosensory cortex yet blunts pain-reactivity in higher-order valuation and decision-making regions of the striatum and insula cortex. Consistent with this altered neural signature, we further show that sleep deprivation expands the temperature range for classifying a stimulus as painful, specifically through a lowering of pain thresholds.

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Optimizing pharmaceutical management in melanoma care

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Pharma is paying a huge price by delaying predictive maintenance

December 06, 2022 | 2:00PM EST

For decades, regulatory bodies like the FDA have created a culture of risk aversion. In response, pharma and medical product companies have designed maintenance programs that over-inspect and over-spend on equipment.
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Spotlight

Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following sleep deprivation are unknown. Moreover, it remains unclear whether ecologically modest night-to-night changes in sleep, within an individual, confer consequential day-to-day changes in experienced pain. Here, we demonstrate that acute sleep-deprivation amplifies pain reactivity within human (male and female) primary somatosensory cortex yet blunts pain-reactivity in higher-order valuation and decision-making regions of the striatum and insula cortex. Consistent with this altered neural signature, we further show that sleep deprivation expands the temperature range for classifying a stimulus as painful, specifically through a lowering of pain thresholds.

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