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THE ROLE OF IMMUNE CELLS AND IMMUNE CHECKPOINTS IN MULTIPLE MYELOMA

November 21, 2019 | (9.00 AM)
USA (United States of America)
Multiple Myeloma is a disease of terminally differentiated plasma cells with the massive production of monoclonal immunoglobulins in the bone marrow. Today there are many treatment modalities ongoing targeting the myeloma microenvironment, but especially immunotherapy seems to be a promising approach. Immune checkpoints are critical components in the regulation of immune cell responses. If immune cells are activated due to the contact to an antigen, they also need to be controlled to prevent an overactive immune response. These control checkpoints are often over-expressed in cancer cells and therefore protect them from the tumor-specific immune response enabling tumor immune escape.