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DECIPHERING VIRAL INFECTIONS: MECHANISMS OF THE CELL-INTRINSIC INNATE IMMUNE RESPONSE

September 16, 2020
USA (United States of America)
SHARESHARESHARE
Building a detailed understanding of viral infection mechanisms and host immune response is critical to developing new treatments for infectious disease. The ability of innate immune cells to detect pathogens via sensing of foreign nucleic acids is a key first step in triggering immune signaling pathways for host defense. Research has revealed how specific DNA and RNA sensors are coupled to a cascade of immune responses, including the upregulation of transcriptional programs and the activation and release of mature cytokines.