USANA launches new, cutting-edge Mood and Relaxation product line at Americas and Europe Virtual Convention

Prnewswire | August 18, 2020

Managing occasional stress and keeping a calm mind are vital for navigating today's world. And USANA's new Mood and Relaxation product line is designed to help. The company's annual Americas and Europe Convention went virtual this year, and USANA continued to impress with the launch of its new Stress Relief mood-support supplement and Calm Response essential oil balm. These products take a natural and mindful approach to overall health and well-being.* To find out more about USANA and its new Mood and Relaxation product line, please visit usana.com. "The launch of our new product line marks a pivotal moment in USANA's history," says Dan Macuga, USANA's chief communications and marketing officer. "We are expanding our reach into a new market space, and the quality of our new products prove it's a space we belong. Day-to-day stressors and obstacles can be overwhelming, and I'm proud USANA has formulated products to help our customers maintain positive emotional health."

Spotlight

Introduction & Welcome: Fake Medicines - Imminent Risks to Global Health to Global Health.David Taylor, Professor of Pharmaceutical and Public Health Policy, UCL School of Pharmacy.

Spotlight

Introduction & Welcome: Fake Medicines - Imminent Risks to Global Health to Global Health.David Taylor, Professor of Pharmaceutical and Public Health Policy, UCL School of Pharmacy.

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Ionis Pharmaceuticals, Inc. the leader in RNA-targeted therapies, announced the closing of the collaboration agreement with AstraZeneca to develop and commercialize eplontersen, Ionis' investigational antisense medicine for the treatment of transthyretin amyloidosis, following expiration of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976. Eplontersen, formerly known as IONIS-TTR-LRx, is designed to reduce the production of transthyretin, or TTR protein, to treat ATTR, a systemic, progressive and fatal disease. It uses Ionis' advanced LIgand-Conjugated Antisense technology. As previously announced, the companies will jointly develop and commercialize eplontersen in the U.S. AstraZeneca has an exclusive license for eplontersen outside the U.S., except certain countries in Latin America. Under the terms of the agreement, Ionis will receive a $200 million upfront payment, up to $485 million in development and approval milestones, and up to $2.9 billion in sales-related milestone payments. The collaboration includes territory-specific development, commercial and medical affairs cost-sharing provisions. Ionis is also eligible to earn royalties in the range of low double-digit to mid-20s percentage depending on region. Additional details about the agreement can be found in Ionis' Form 8-K filed with the Securities and Exchange Commission on Dec. 7, 2021. About Ionis Pharmaceuticals, Inc. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with its novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading neurological and cardiometabolic franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision of becoming one of the most successful biotechnology companies.

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Royalty Pharma Acquires Royalty Interest in ORLADEYO and BCX9930 From BioCryst Pharmaceuticals

Royalty Pharma | December 08, 2020

Royalty Pharma, BioCryst Pharmaceuticals, Inc. what's more, Athyrium Capital Management, LP today declared exchanges adding up to $325 million in financing for BioCryst, with $250 million accessible at shutting, to help the dispatch of ORLADEYO™ (berotralstat) in genetic angioedema (HAE) and the advancement of its oral Factor D inhibitor, BCX9930. Royalty Pharma will furnish BioCryst with a forthright money installment of $125 million and will get eminences of 8.75% on direct yearly net deals of ORLADEYO up to $350 million, 2.75% on deals between $350 million and $550 million, no royalty on deals over $550 million, and a layered level of sublicense income for ORLADEYO in specific domains. Likewise, Royalty Pharma will get a 1.0% royalty on worldwide net deals of BCX9930, whenever affirmed. An asset oversaw by Athyrium Capital Management will give BioCryst a $200 million credit office, of which BioCryst will draw $125 million at shutting. The extra capital will be accessible in two tranches at BioCryst's alternative, after arriving at characterized income achievements. The credit office bears revenue at LIBOR +8.25% (with a LIBOR floor of 1.75%) and is revenue just for the whole five-year term, with all extraordinary head due at development. Also, BioCryst has the choice to pay revenue in-kind for the initial eight fourth of the term, permitting the organization to concede money premium installments until after this period. The organization will be dependent upon a base liquidity contract of $15 million. There are no other monetary agreements except if the third tranche is drawn by BioCryst. BioCryst plans to contribute the joined continues to help the dispatch of ORLADEYO in the U.S. what's more, Europe and to propel the advancement of BCX9930 into clinical preliminaries in various supplement intervened sicknesses. Also, BioCryst will reimburse its current office with MidCap Financial. "We trust ORLADEYO will be a groundbreaking medication and we are eager to cooperate with BioCryst to bring this oral, once-every day medication to HAE patients. In view of the empowering verification of idea information in paroxysmal nighttime hemoglobinuria with BCX9930, we likewise accept this oral Factor D inhibitor offers considerable open doors over different supplement interceded sicknesses," said Pablo Legorreta, Chief Executive Officer of Royalty Pharma. "With a productive R&D ability, long IP on their items and huge close term business openings, BioCryst speaks to the ideal profile Athyrium looks for our speculations and we are eager to add to the organization's future achievement," said Hondo Sen, accomplice at Athyrium Capital Management. "The generous monetary responsibility of extraordinary long haul accomplices like Royalty Pharma and Athyrium Capital Management empowers BioCryst to completely put resources into the dispatch of ORLADEYO and to quicken the advancement of BCX9930 to address a neglected requirement for patients and convey an incentive to investors. We accept the present financing mirrors the subsequent stage in the change of BioCryst," said Jon Stonehouse, Chief Executive Officer of BioCryst. Cowen went about as monetary guide to BioCryst on the exchange. Gibson Dunn went about as lawful consultant to BioCryst. Goodwin Procter, Wolf Greenfield and Maiwald went about as legitimate counsels to Royalty Pharma. Hogan Lovells went about as lawful counselor to Athyrium Capital Management.

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