Positive CHMP approval for Takeda's Alunbrig in ALK advanced non-small lung cancer

Pharmafile: Home | March 04, 2020

The decision was based on Phase 3 comparing Alunbrig to crizotinib in the same indication. The findings for Alunbrig showed a 69% reduction in risk of intracranial disease progression or death in patients with brain metastases according to a blinded independent review committee, and a 76% reduction according to investigators. The drug also demonstrated a median progression-free survival of 24 months, more than double the 11 months presented by crizotinib. Because of the complex nature of ALK+ NSCLC and the way in which the disease often spreads to the brain, it is essential for physicians to have treatment options that demonstrate both overall and intracranial effectiveness,” explained Professor Sanjay Popat, Consultant Medical Oncologist, Royal Marsden NHS Foundation Trust. “In the ALTA-1L trial, brigatinib demonstrated significant responses in the brain and consistent overall efficacy compared to crizotinib. If approved by the EMA, brigatinib has the potential to become an important option for the first-line treatment of ALK+ advanced NSCLC patients in Europe.

Spotlight

Globally operating finish pharmaceutical company Orion Corporation and American publicly traded generics and specialty pharmaceutical company AMNEAL Pharmaceuticals are set to enter into a strategic partnership.

Spotlight

Globally operating finish pharmaceutical company Orion Corporation and American publicly traded generics and specialty pharmaceutical company AMNEAL Pharmaceuticals are set to enter into a strategic partnership.

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IntegriChain Partners with PurpleLab to Enhance Pharmaceutical Channel Data for More Accurate GTN Forecasting and Accruals

IntegriChain | November 18, 2022

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BUSINESS INSIGHTS

Silo Pharma Issues Letter to Shareholders Detailing Progress on Pipeline Assets Combining Traditional Therapeutics with Psychedelic Medicine

Silo Pharma, Inc. | December 02, 2022

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BUSINESS INSIGHTS, PHARMACY MARKET

Shields Health Solutions Increases Specialty Pharmacy Services Nationwide

Shields Health Solutions | January 12, 2023

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