Orion Biotechnology Successfully accomplishes Phase 1 Clinical Trial of a First-in-Class Precision Engineered Ligand Analog for HIV Prevention

Orion Biotechnology Canada Ltd | October 16, 2020

Orion Biotechnology Canada Ltd., a clinical stage pharmaceutical company focused on precision engineering GPCR-targeted therapeutics, today announced the results of their Phase 1 study of OB-002H which is an investigational candidate microbicide for HIV prevention. The Phase 1 study was a first-in-man trial designed to evaluate the safety, acceptability, and pharmacokinetic profile of OB-002H gel. OB-002, a highly potent chemokine analog of CCL5 (a ligand for the CCR5 HIV co-receptor), has previously been shown to be completely protective in a non-human primate model of vaginal HIV transmission (Veazey R et al. JID 2009). The Phase 1 study design included open-label single-dose (vaginal and rectal) and multi-dose product (vaginal) administration of OB-002H gel to study participants followed by a randomised, double-blind, placebo-controlled multi-dose (vaginal) phase of product administration. During the multi-dose phase of the study, participants received study product once daily for five days. The study enrolled a total of 30 healthy volunteers in Warsaw, Poland at the BioVirtus Phase 1 Research Site. The product was well tolerated, and product-related genital adverse events were mild (Grade 1) or moderate (Grade 2) and transient.

Spotlight

Sylintis works with technology called RAN interference (iRAN) for the development of new drugs. Through this technology, Sylintis Achieves gene silencing of the RAN messenger.

Spotlight

Sylintis works with technology called RAN interference (iRAN) for the development of new drugs. Through this technology, Sylintis Achieves gene silencing of the RAN messenger.

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Cascade Chemistry | February 19, 2021

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BUSINESS INSIGHTS

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PostEra | May 19, 2022

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PHARMA TECH

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Sebela Pharmaceuticals | January 06, 2021

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