New genomics tool ECCITE-seq expands multimodal single cell analysis

A new technique called ECCITE-seq, developed by scientists at the New York Genome Center's (NYGC) Technology Innovation Lab (@NYGCtech), allows researchers to perform high-throughput measurements of multiple modalities of information from single cells. The technique, ECCITE-seq, published today in Nature Methods, stands for Expanded CRISPR-compatible Cellular Indexing of Transcriptomes and Epitopes by sequencing. ECCITE-seq profiles different types of biomolecules from thousands of single cells in parallel, offering a breadth of information that can be used as readout in CRISPR-based pooled genetics screens. "ECCITE-seq is a next-generation tool that enhances our ability to more thoroughly investigate single cells and better understand disease mechanisms," said Tom Maniatis, Ph.D., NYGC's Scientific Director and Chief Executive Officer.