Nanoparticles for RNA Vaccine Delivery Help Stop Melanoma Tumor Growth

Medgadget | October 01, 2019

Nanoparticles for RNA Vaccine Delivery Help Stop Melanoma Tumor Growth
RNA vaccines are a promising way to harness the immune system to fight cancers and infections. Some are currently in clinical trials, but the technology is still in its early stages. A major impediment to the effectiveness of RNA vaccines is the difficulty in getting them into the correct immune cells to produce the desired proteins and guaranteeing that the immune system will respond with sufficient force. To help with this, chemists at MIT have created a range of lipid nanoparticles that can be used as delivery vesicles for RNA vaccines. These nanoparticles have already been shown to improve target protein production and increase the effectiveness of the immune system in fighting melanoma tumors in mice. “One of the key discoveries of this paper is that you can build RNA delivery lipids that can also activate the immune system in important ways,” said Daniel Anderson, the senior author of the study, in an MIT press release. RNA vaccines have to penetrate antigen-presenting cells to induce them to produce a protein that will signal T cells and other immune cells to attack a target cell or tissue involved in disease. The MIT researchers synthesized thousands of lipid nanoparticles and picked out ones that had the desired chemical features, specifically a cyclic structure at the tip of the nanoparticles that seems to activate the stimulator of interferon genes (STING) signaling pathway. When it is active, STING makes cells produce cytokines that make T cells do their signature tricks.

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BUSINESS INSIGHTS

Element Further Expands Its Life Sciences Testing Business With Additional Pharmaceutical and Biotech Testing Capabilities in North America and Europe

Element Materials Technology | January 15, 2022

Element Materials Technology (Element) completed its sixth life sciences-focused acquisition of 2021, with the formal completion of the acquisition of JMI Laboratories. Element has now built out its expertise and capability for pharmaceutical and biopharmaceutical customers, expanding to a team of more than 1,000 experts in 23 facilities across North America and Europe. This significant step change in pharmaceutical and medical testing capabilities from Element forms part of its broader strategic shift to increase its global presence in Life Sciences and Connected Technologies. “Our expansion into life sciences and connected technologies over the last two years has seen us gain a leadership position in these strategically important end-markets. As we celebrate 10 years of being a standalone Element business, we see more and more opportunities to work closely with our customers throughout their product and testing lifecycles.” Jo Wetz, Element CEO Cherie Gudz, Vice President, Life Sciences Americas, said: “In a world still dealing with a pandemic, the life sciences sector has never been more vital. The six acquisitions this past year alone cements Element’s commitment to continue to build a scale business in this vital sector, which now forms our largest global end-market. We are thrilled to have JMI’s team and expertise join the Element family”. Based in North Liberty, Iowa, JMI is a market leader in antimicrobial resistance monitoring studies utilized for US-FDA regulatory and new drug application submissions, through their proprietary SENTRY Antimicrobial Surveillance Program. It offers microbiology and molecular testing services to assist in the development of new antimicrobials and clinical trial support. The Company is CLIA accredited and able to test under GLP conditions. The business is notable for its team of highly scientific and well-published industry recognized experts in the field, including 10 MD/PhDs with extensive knowledge of microbiology and antimicrobials, and can consult on a broad range of scientific topics covering epidemiology, mechanisms of resistance in bacterial and fungal organisms, microbiology diagnostics and susceptibility testing methods.

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Takeda, debt in mind, offloads 18 drugs in Asia Pacific to Celltrion for $278M

Fiercepharma | June 11, 2020

Takeda has earmarked another chunk of business for divestment to help it pay down debt. The Japanese pharma is offloading 18 over-the-counter and prescription drugs marketed in the Asia-Pacific region to South Korea’s Celltrion for $278 million, it said on Thursday. The portfolio generated sales of about $140 million in the fiscal year ended in March 2019, mainly driven by DPP-4 diabetes drug Nesina and hypertension med Edarbi, Takeda said. It will continue to manufacture the products and supply them to Celltrion after the transaction closes. Takeda expects the deal to wrap up by the end of the year. As is the case with its previous deals, the sold-off drugs fall outside of Takeda’s chosen focus business areas—gastroenterology, rare diseases, plasma-derived therapies, oncology and neuroscience.

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PHARMA TECH

Aidoc and Subtle Medical Partner to Bring End-to-End AI Solutions to Medical Imaging

Aidoc | September 15, 2021

Aidoc, leading provider of AI for medical imaging, announced today a partnership with Subtle Medical, developer of leading AI-based image enhancement bringing best-of-breed AI to both image acquisition and post-acquisition clinical workflows. Aidoc has developed the industry's most robust AI platform, delivering a unified and seamless cross-specialty AI experience for physicians in over 500 medical centers, including the largest clinical deployment of AI in healthcare at Radiology Partners. "Mainstream healthcare adoption of AI requires both a comprehensive package of premier AI solutions and an ability to deliver their results in a reliable and seamless manner across physician workflow, Through this partnership, we will provide health systems and imaging centers with Subtle Medical's optimal solution, now seamlessly delivered through a unified AI architecture. Our platform's ability to deliver interoperable AI solutions is a game changer for AI adoption." - Tom Valent, VP of Business Development at Aidoc. A pioneer in healthcare AI, Aidoc's FDA-cleared solutions analyze medical images for critical conditions and trigger actionable alerts directly in the imaging workflow supporting medical specialists in reducing turnaround time and improving quality of care. Subtle Medical's AI-powered software solutions, SubtlePET™ and SubtleMR™ are image enhancement tools that increase the efficiency of image capture by improving the quality of accelerated scans. This enables optimized scan times and can potentially increase the number of patients scanned per day. Subtle's solutions are compatible with all scanner brands, models and field strengths so institutions can see the benefit across their entire scanner fleet. "This agreement will provide our customers with a multimodality solution that includes acquisition workflow efficiencies and image quality improvements together with Aidoc's post-acquisition clinical workflow solutions, We believe that the integration of Subtle's AI-based software tools with the Aidoc platform will dramatically change the medical imaging equation." - Josh Gurewitz, Chief Commercial Officer at Subtle Medical. About Subtle Medical Subtle Medical, Inc. is a leading healthcare technology company making medical imaging faster, safer, and smarter. For more information, visit subtlemedical.com. About Aidoc Aidoc is the leading provider of artificial intelligence solutions that support and enhance the impact of physician diagnostic power - helping them expedite patient treatment and improve quality of care.

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Spotlight

Cloud computing represents an IT service model which helps in the delivery of computing services, both hardware and software, to customers, on demand, over a network, which utilizes the internet. Thus, users only incur operating expenses associated with the time and length of usage, and are not required to make any initial capital expenditures.