Merck and AZ pile on more positive Lynparza data in bid to break into prostate cancer

FiercePharma | August 07, 2019

Merck and AZ pile on more positive Lynparza data in bid to break into prostate cancer
Two months back, AstraZeneca and Merck made a strong case at the American Society of Clinical Oncology ASCO annual meeting that Lynparza should be the first PARP inhibitor approved to treat prostate cancer, with data showing the drug significantly delayed disease progression when added to Johnson and Johnsons Zytiga. Now the Lynparza partners have a fresh set of data to back up their case, and this time its for use of the drug as a solo therapy. Merck and AstraZeneca said they have seen positive results from a phase 3 trial of Lynparza in men with metastatic castration-resistant prostate cancer and a mutation in a homologous recombination repair (HHR) gene. The men in the trial had progressed after receiving either Zytiga or Astellas’ and Pfizer’s Xtandi. The companies said there was a “statistically significant and clinically meaningful improvement” in progression-free survival among trial participants taking Lynparza over those on either Zytiga or Xtandi. They plan to present the full data at an upcoming medical meeting.

Spotlight

Antibodies are a critical feature of the human adaptive immune response. New immunotherapies require the production of selective and non-autoimmunogenic antibodies. These engineered antibodies can convert proteins from a threat recognition agent, into a disease-fighting form. Transgenic mice allow researchers to create “humanized” mice with human equivalents of murine antibody-coding genes. High throughput production of chimeric antibodies with murine-constant regions and human-variable regions has tremendous implications for both research and clinical purposes.

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ERT | April 16, 2021

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BenchSci, Deloitte Technology Fast 50™ | November 23, 2021

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Fusion Pharmaceuticals Inc. | August 13, 2021

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Antibodies are a critical feature of the human adaptive immune response. New immunotherapies require the production of selective and non-autoimmunogenic antibodies. These engineered antibodies can convert proteins from a threat recognition agent, into a disease-fighting form. Transgenic mice allow researchers to create “humanized” mice with human equivalents of murine antibody-coding genes. High throughput production of chimeric antibodies with murine-constant regions and human-variable regions has tremendous implications for both research and clinical purposes.