Haymarket Media Introduces New Data Offering for Pharma Marketers

PR Newswire | November 18, 2019

Haymarket Media is proud to announce the official launch of Haylo, a transformative data offering that connects pharma marketers with millions of verified healthcare professionals. Built on Haymarket's 30-plus years of healthcare expertise and borne out of the need to make sense of the fragmented data in the healthcare advertising space, Haylo transforms disparate data points into actionable solutions, providing pharma marketers the opportunity to strategically engage with their target audience. The Haylo suite of products features three core offerings: Haylo HCP, Haylo Consumer, and Haylo Rep. Haylo HCP provides advertisers the unique ability to reach their target healthcare professionals (HCPs) at the 1:1 level. Leveraging Haymarket's 1st party opt-in data, pharma marketers can activate non-endemic cross-device programs with full reporting. Haylo Consumer is a direct-to-consumer solution that combines contextual history on Haymarket's ever-expanding portfolio of clinical websites with its understanding of HCPs' prescribing and diagnosis patterns to create custom audiences.

Spotlight

The Medical Device Summit delivered world class briefings from some of the leading minds in the Medical Device industry. Join the next Summit along with top industry manufacturing and R&D professionals and solution providers in an intimate environment for a focused discussion on the key drivers of the medical device industry.

Spotlight

The Medical Device Summit delivered world class briefings from some of the leading minds in the Medical Device industry. Join the next Summit along with top industry manufacturing and R&D professionals and solution providers in an intimate environment for a focused discussion on the key drivers of the medical device industry.

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PHARMA TECH

Ranok Therapeutics Announces Agreement with Pfizer on Targeted Protein Degradation

Ranok Therapeutics | November 30, 2021

Ranok Therapeutics Co. Ltd., an emerging biopharmaceutical company focused on developing breakthrough therapies for cancer and other serious diseases, announced an agreement with Pfizer Inc. to apply and evaluate Ranok’s CHAMP™ platform technology on an undisclosed cancer target. Terms of the agreement were not disclosed. Ranok has developed a proprietary and innovative targeted protein degradation (TPD) platform technology, CHAMP™ (Chaperone-mediated Protein Degradation), which leverages Ranok’s founders’ expertise in protein homeostasis to take advantage of the cellular chaperone network, potentially improving drug safety and efficacy due to selective targeting of disease tissues. “We are very pleased to work with Pfizer to explore the application of CHAMP™ to an emerging cancer drug target, This represents our first pharmaceutical company research relationship and is an important step forward in establishing CHAMP™ as a preferred technology in the rapidly-growing field of targeted protein degradation. We look forward to uncovering new benefits of CHAMP™ through this research.” Kevin P. Foley, Ph.D., Co-founder and Chief Scientific Officer of Ranok Therapeutics This evaluation agreement builds upon Ranok’s recent momentum, including its $40 million Series B financing in August 2021. About Ranok Therapeutics Ranok is a privately held, emerging biopharmaceutical company that is pioneering its proprietary CHAMP™ platform technology, an innovative approach to targeted protein degradation (TPD) for the discovery and development of novel therapeutics. Ranok was founded by a leadership team composed of industry veterans from both Chinese and American biotech and pharmaceutical companies and is based in two of the world’s leading centers of innovation and medical research: Hangzhou China and Greater Boston, Massachusetts. By bringing together cutting-edge medical research from both China and the United States, Ranok’s goal is to create transformative medicines to benefit patients suffering from cancer and other serious diseases around the world. For more information, please visit the company website at www.ranoktherapeutics.com or follow us at LinkedIn and on Twitter @RanokTx. About Ranok’s CHAMP™ platform Chaperone-mediated Protein Degradation/Degrader technology is based on our founders’ extensive backgrounds in protein homeostasis research. This technology takes advantage of the cellular chaperone network, distinguishing it from other targeted protein degradation (TPD) approaches. CHAMP™ has a number of unique advantages, including improved safety due to the selective targeting of tumors. Our proprietary R&D engine combines deep biological insight and chemistry expertise to iteratively discover and test new leads, rapidly identifying and advancing optimal development candidates for a variety of important disease targets.

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RESEARCH

Ascentage Pharma Enters into an Agreement with University of Michigan to obtain an exclusive license for Degrader

Ascentage Pharma | November 30, 2020

Ascentage Pharma (6855.HK), an internationally engaged, clinical-stage biotechnology organization occupied with creating novel treatments for malignant growths, ongoing hepatitis B (CHB), and age-related infections, today reported it has gone into a concurrence with the University of Michigan, through which the organization may acquire the selective worldwide rights to a MDM2 protein degrader created utilizing the Proteolysis-Targeting Chimeras (PROTACs) innovation. The medication competitor is as of now entering IND-empowering considers. MDM2 is a critical controller of the tumor silencer p53 and one of the most powerful inhibitors of apoptosis found hitherto. It has high articulation in tumors and assumes a critical part in the event and advancement of tumors. Official to the MDM2 protein with high proclivity, MDM2 inhibitor hinders the MDM2-p53 connections and reestablish the tumor-stifling action of p53.1 Meanwhile, these MDM2 inhibitors present a few difficulties, including portion restricting hematological poison levels, in this manner the pressing need to grow new age of MDM2-focusing on treatments in the therapy of disease. The PROTAC innovation has arisen as another and promising methodology that initiates the corruption of focused proteins through the ubiquitin-proteasome framework (UPS), and it has gotten boundless interest from both mainstream researchers and enterprises since its presentation. Contrasted with ordinary "inhabitance driven" pharmacological methodology, the "occasion driven" PROTAC innovation has numerous focal points, for example, high intensity, high selectivity, with reactant method of activity, and the capacity to target undruggable proteins.2 Prof. Shaomeng Wang, Ph.D., Co-Founder of Ascentage Pharma and Chairman of its Scientific Advisory Board, and Warner-Lambert/Parke-Davis Professor in Medicine, Professor of Internal Medicine, Pharmacology and Medicinal Chemistry, Director of Michigan Center for Therapeutic Innovation, University of Michigan, is a main specialist in the field. Through structure-work investigations of their recently found MDM2 inhibitors utilizing the PROTAC innovation, Dr. Wang's exploration group has gotten intense and viable MDM2 degraders that could adequately actuate fast debasement of MDM2. The lead MDM2 degrader has accomplished total and tough tumor relapse in a xenograft tumor model in mice3. "As a new strategy to induce protein degradation, PROTAC has emerged as a novel modality in drug discovery," said Dr. Wang. "Studies showed, PROTAC-induced MDM2 degradation can not only enhance the potency of MDM2 inhibitors, but also maintain a long-lasting suppression of MDM2 protein levels, providing a new strategy to the treatment of MDM2-driven tumors such as leukemia. We look forward to the further development of the asset by Ascentage Pharma." "The emergence of the PROTAC technology represents another breakthrough in the identification of small molecule drugs. The technology has received tremendous interest for its ability to target undruggable proteins," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. "We are very pleased to reach this agreement with the University of Michigan, to begin the assessment of this PROTAC-based MDM2 degrader and potentially bring this important addition to our existing pipeline. Through the assessment and potential development of the MDM2 degrader, we hope soon that it will offer an effective therapy for serious unmet medical needs."

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RESEARCH

Parexel and Veeva Collaborate to Speed-Up Clinical Trials

Parexel, Veeva Systems | May 04, 2021

Parexel and Veeva Systems announced a strategic partnership today to accelerate clinical trials through technological and process innovation. The unique partnership blends the best of each company's expertise through thousands of tests worldwide – Parexel as a pioneering CRO and Veeva as the technological innovator powering trials – to boost study performance and bring innovative therapies to patients faster. Parexel is standardizing Veeva's suite of clinical operations software, including Veeva Vault eTMF, Vault CTMS, and Vault Study Startup, as part of the agreement to streamline operations. Parexel's clients will now have access to Veeva Vault CDMS for clinical data storage as a free product. The companies will work together to continually develop Veeva's cloud technology and Parexel's clinical trial delivery processes based on the insights from sponsors, sites, and patients. Parexel will provide early access to and give feedback on Veeva's clinical products, such as innovations to support sites and patients in decentralized clinical trials (DCT), risk-based quality management (RBQM), and community-based sites. "By implementing Veeva's clinical solutions, we can streamline trial procedures, increase performance, and make trial implementation and attendance simpler for promoters, locations, and patients," Parexel CEO Jamie Macdonald said. "Through this extended relationship with Veeva, we hope to have more value to customers and have a much greater effect on the lives of patients." "We're happy to work with Parexel to fuel customer success and accelerate clinical research innovation," said Peter Gassner, Veeva's founder, and CEO. "By working together, we will help our customers get new vaccines, diagnostics, devices, and therapies to patients in need" About Parexel Parexel encourages the development of new innovative drugs to improve patient health. It provides services to clients in the life sciences and biopharmaceutical industries all over the world to help them transform scientific discoveries into new treatments. The therapeutic, technological, and functional ability is underpinned by a strong conviction in what we do, from decentralized clinical trials to regulatory advisory services to exploiting real-world insights. An independent council for Informa Pharma Intelligence voted Parexel the "Best Contract Research Organization" in December 2020. About Veeva Systems Veeva is the world's leading provider of cloud software for the life sciences industry. Veeva represents over 975 clients, ranging from the world's leading pharmaceutical firms to new biotechs, and is dedicated to innovation, product excellence, and customer success. Veeva is committed to balancing the needs of all stakeholders, including customers, employees, shareholders, and the industries it serves, as a Public Benefit Corporation.

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