Each year, invasive fungal infections sicken an estimated 2 million people worldwide and kill nearly 800,000 - but a team of international scientists have discovered a new approach for antifungal drug treatments. Researchers from USC and France identified that a gene-regulating protein, Bdf1, is critical for the survival of the pathogenic fungus....
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AstraZeneca has announced that its combination of Imfinzi durvalumab and tremelimumab has failed to hit its key target in a late-stage trial assessing its potential in patients with late-stage lung cancer. The drug giant reported that in the primary analysis population - patients with stage IV non-small cell lung cancer NSCLC whose blood TMB was 20 or more mutations per megabase - the combination did not meet the primary endpoint of improving overall survival (OS) compared to standard of care (S...
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Biogen’s top-selling Tecfidera (dimethyl fumarate) has proven to be an effective treatment for multiple sclerosis, bringing in $4.27 billion in sales in 2018, but its exact mechanism of action remains a mystery. Now scientists from the City University of New York and the Icahn School of Medicine at Mount Sinai have identified a possible mechanism of action, providing information that they believe could lead to better drugs for MS and other autoimmune diseases. MS happens when brain-homing ...
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FDA Commissioner Scott Gottlieb, M.D., hasn’t been shy about allying with President Donald Trump on the subject of high drug prices. Even though pricing is not the FDA's purview, Gottlieb has vowed to do his part to bring down drug costs by speeding up approvals of generics, for example, and cracking down on companies that try to stifle generic competitors. But Gottlieb’s latest idea has raised some eyebrows in the pharma community because it attacks a fundamental strategy drug c...
FIERCEPHARMA
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AbbVie’s rheumatoid arthritis drug upadacitinib is at the top of a new list of drugs due to launch this year that are expected to make blockbuster sales by 2023. JAK1 inhibitor upadacitinib for rheumatoid arthritis will be a $2.2 billion product by that time, predicts Clarivate Analytics, despite launching into a crowded market. That’s good news for AbbVie, which needs upadacitinib and other late-stage candidates to deliver big sales before its big-selling immunology drug Humira (ada...
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A Maryland bill would start investigations and impose fines to stop generic drug companies from increasing their prices exorbitantly....
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