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Your Cancer Targets May Not Be Real

September 12, 2019 / DEREK LOWE

A paper from Cold Spring Harbor labs that invalidated MELK as a cancer target. That was straightforward enough: knocking it out via CRISPR across a whole range of cancer cell lines had no effect on their growth at all, so it’s kind of hard to make the case that it’s an important thing to go after. At the same time, the paper showed that a MELK inhibitor with activity in cancer cells continued to show such activity after the target had been deleted.