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Method “Matches” Medicines to Their Unique Protein Receptors

October 10, 2019 / LAURA ELIZABETH LANSDOWNE AND MOLLY CAMPBELL

A receptor (drug target) can shift from a single subunit to a multi-structure in the presence of a ligand (drug compound) – a process known as "oligomerization". Having a method to determine exactly how different drug compounds target the same receptor is key to understanding why and how some candidates are effective while others are not. Now, using photon excitation microscopy, researchers report that they can uncover the various protein receptor oligomers formed in the absence or presence of different drug candidates that bind to them.