How a single payer system can help solve the US opioid crisis

The US now has only a decade to achieve both universal health coverage and to prevent and treat substance abuse under the United Nations’ 2030 Sustainable Development Goals. Katherine Pettus argues that adopting a single-payer public health system is likely to be the only way to achieve these targets. Government procurement agencies, she writes, will also need to overcome the stigma attached to morphine for palliative care and the treatment of substance use disorder.

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Pinnacle Biologics, Inc.

Pinnacle Biologics specializes in revitalizing healthcare therapies by promoting, developing and managing innovative approaches to the global commercialization of products in the oncology and specialty areas.

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Pharma Tech

How long will the world wait for the next pandemic of antimicrobial resistance before we act?

Article | July 20, 2022

Antimicrobial resistance (AMR) has become an increasingly serious global health problem in recent years. World Health Organization (WHO) estimates that more than 700,000 people die each year due to drug-resistant infections, and the number is expected to increase in the coming years. How does antimicrobial resistance emerge? Antimicrobial resistance (AMR) occurs when bacteria, viruses, fungi, and parasites change over time and no longer respond to medicines. It makes infections harder to treat and increases the risk of disease, severe illness, and death. When we use antibiotics, some bacteria die, but resistant bacteria can survive and even multiply. The overuse of antibiotics and substandard antibiotics make resistant bacteria more common. So, the more we use antibiotics, the more chances bacteria have to become resistant to them. The rise in AMR is caused by multiple factors including the misuse and overuse of antibiotics by humans as well as in livestock and agriculture. Although these are the main drivers in the development of drug-resistant pathogens, the emergence of substandard and falsified antibiotics is another lesser-known, huge contributory factor. Even though AMR is a leading cause of death around the world, it is tracked most closely in clinical high-income settings and developed countries. Unfortunately, this is not the case in low and middle-income countries, where the highest burden is in low-resource settings and low-and middle-income countries (LMICs). These countries are disproportionately affected, in part due to the high burden of communicable diseases. Consequences to human health of AMR AMR poses significant risks to human health, resulting in prolonged and more severe infections, extended hospitalizations, and increased healthcare expenses. It can also lead to an increased risk of death, as an infection may become untreatable. Additionally, it can reduce the effectiveness of medicines and treatments, making it more difficult to manage existing medical conditions. It is even more concerning that it can lead to the emergence of new, more dangerous strains of bacteria, viruses, and other microbes. This would mean medical procedures, such as surgery, including caesarean sections or hip replacements, cancer chemotherapy, and organ transplantation, will become riskier. Counterfeit medicines and antibiotics: Antibiotics are the most counterfeited medicines in the world, as they account for 28% of global counterfeit medicines. Substandard and falsified antibiotics are medicines that do not meet the quality standards set by regulatory authorities. Counterfeit antibiotics are estimated at 5% of the global antibiotic market. These medicines are often of inferior quality or contain incorrect ingredients or incorrect amounts of active ingredients. They may also contain toxic contaminants or be expired, posing serious consequences for patients. Sadly, counterfeit antibiotics are mostly found in LMICs due to a lack of regulation and enforcement, as well as a lack of access to quality healthcare. In many of these countries, the demand for antibiotics is higher than the supply, and counterfeit antibiotics are seen as a cheaper and more accessible alternative. Furthermore, there is a lack of awareness around the dangers of taking counterfeit antibiotics, and there is a lack of resources for health authorities to test for the authenticity of these medicines. Why are antibiotics so rife for counterfeit drugs? Counterfeiters of pharmaceuticals succeed in large part by exploiting weaknesses in supply chains, which are often fragmented with poor regulatory frameworks. Antibiotics are often counterfeited because they are in high demand and can be sold for a large profit. To combat the problem of substandard and falsified antibiotics, governments must take a multi-pronged approach. This should encompass enacting laws and regulations to ensure the quality and safety of medicines, conducting surveillance for detecting and removing substandard and falsified products from the market, as well as providing training and education to healthcare professionals and patients regarding the responsible use of antibiotics. In addition, governments must work to strengthen the pharmaceutical supply chain. This includes increasing the transparency of the supply chain, improving the quality control systems, and introducing traceability systems to track the movement of medicines from the manufacturer to the patient. Medical investment in low and middle-income countries Another neglected aspect by international NGOs and governments is investment in building local laboratory capacity in LMICs to combat antimicrobial resistance. Localized laboratory facilities can help identify, track, and prevent the spread of antimicrobial-resistant infections, as well as provide early warnings of emerging drug-resistant strains. Localized microbiology, surveillance, and quality control laboratories can also play an important role in developing new treatments and interventions for combating antimicrobial resistance. In addition, having localized laboratory capacity can provide more accurate standardized data on the prevalence of drug-resistant infections, which can help inform policy decisions and public health interventions. Affordable medicines Finally, governments must work to increase access to high-quality, affordable medicines. This includes improving the availability of generic medicines, which are typically cheaper alternatives to brand-name drugs. They also need to increase access to newer, more effective antibiotics.

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Pharmacy Market

Tips for Managing Chronic Pain Beyond Prescription Painkillers

Article | July 7, 2023

Painkillers like Oxycontin, Percocet, and Vicodin, have been prescribed by primary physicians, surgeons, dentists, and other healthcare providers to patients suffering from varying levels of pain. Though these medications have proven to be an effective source of pain relief, they have also proven to be highly addictive. In fact, it has even been reported that there are more cases of a drug overdose and deaths from prescription painkillers than heroin or cocaine. While there are a number of factors that play into this opioid epidemic, educating doctors and patients on alternative solutions to managing chronic pain is a great place to start combatting this nationwide crisis.

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Pharma Tech

What are the advantages of PCD Pharma Company?

Article | September 29, 2022

PCD Pharma stands for propaganda distribution. A PCD company gives brand name and support to its franchises. They also provide distribution rights and monopoly rights within a particular region. If a person wants to establish their business, it is a must for them to know the pros and cons of the business to make a sound decision. Needless to mention that PCD company has a lot to contribute in the medical filed. Worldwide in a medical field, A PCD Pharma Company is playing an essential and crucial role in the rapid growth. The pharma industry is progressing t a fast pace. The company uses the latest technologies for each brand which ensures the safety of products and accepts the responsibility of human health & life by providing better outcomes. To have a drug license number and company registration, the cost to establish the company is quite cost-effective that is15000-20000rs. So this gives people a brilliant opportunity to have their unit without digging a big hole in their bank balance. Indian produces exquisite quality products, which make pharma companies a considerable success.

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WALGREEN’S IN HOT WATER OVER PHONY PHARMACIST

Article | February 11, 2020

The drugstore chain agreed to pay $7.5 million in fines after an unlicensed pharmacist at several San Francisco Bay locations illegally filled more than 700,000 prescriptions over a ten-year period. According to California prosecutors, Kim Thien Le stole license numbers from other pharmacists to fill prescriptions for Fentanyl, morphine, and other painkillers. Le pleaded guilty to multiple felony impersonation counts. Walgreen’s agreed to the settlement to avoid being charged with consumer fraud in Alameda and Santa Anna Counties. Prosecutors alleged that Walgreen’s failed to verify Le’s license and did not conduct a thorough background check. The company insisted it has taken remedial measures.

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Pinnacle Biologics, Inc.

Pinnacle Biologics specializes in revitalizing healthcare therapies by promoting, developing and managing innovative approaches to the global commercialization of products in the oncology and specialty areas.

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CCA Shows Success in Managing Members’ Pain and Opioid Use

Managed Healthcare Executive | November 11, 2019

The United States is battling an opioid crisis, and it is critically important that healthcare organizations do what they can to identify patients at high risk of suffering from the negative effects of this form of pain management. One organization addressing this issue is Commonwealth Care Alliance (CCA), a not-for-profit healthcare organization that serves more than 32,000 low-income, disabled, and elderly patients across Massachusetts who are dually eligible for Medicare and Medicaid. These individuals are often referred to as “super-users” of the healthcare system, as they make up only 5% of the population but account for about half of healthcare spending. Because of their complex patient profile, 20% of CCA members take opioid medications—a number much greater than the general population. This high rate, combined with the inherent challenges associated with managing pain and care with opioids, led to the creation of CCA’s statewide High Opioid Patient Engagement (HOPE) program, which manages the risk of overdose and reduced opioid dependence among members.

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Opioid Addiction Can be Controlled Using an In-Brain Chip Technology: First U.S. Clinical Trial

LabRoots | November 06, 2019

Opioid addiction is a chronic disease that can cause significant health, social, and economic problems. Opioids are a class of drugs that act in the nervous system to produce feelings of pleasure and pain relief. The overdose of opioids negatively affects a person's personal and professional relationships. Some opioids are legally prescribed by healthcare providers to manage severe and chronic pain. According to the US Department of Health & Human Services, there were 47,600 of opioids overdose deaths, and more than130 people died from opioid-related drug overdoses in 2016 and 2017. Researchers in China conducted the first clinical trial of DBS for methamphetamine addiction at Shanghai's Ruijin Hospital in China, along with tests for opioid addicts. The patients are resistant to the various treatments for opioid addiction. Researchers at the West Virginia University Rockefeller Neuroscience Institute (RNI) and West Virginia University Medicine are conducting the first clinical trial in the US that uses deep brain stimulation (DBS) to treat opioid addiction.

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Purdue Pharma settlements a window into U.S. opioid crisis

The DePaulia | October 21, 2019

After more than 2,600 lawsuits nationwide involving their role in the opioid epidemic sweeping through the country, Purdue Pharma — the manufacturer of prescription painkiller OxyContin — filed for bankruptcy Sept. 16. In 2017, opioids were responsible for 47,600 of the 70,237 U.S. drug overdose deaths — with more than 28,000 of these opioid-related deaths being attributed to synthetic opioids, such as fentanyl. From 1999 to 2017, more than 400,000 Americans have died from opioid overdoses. The declaration of bankruptcy followed a tentative $10 to $12 billion settlement with 27 states and thousands of cities and counties throughout the nation — with nearly 20 other states rejecting the terms of the settlement. Dr. Richard Blondell, physician and vice chair for addiction medicine at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, said the company’s heavy marketing downplaying the addictive nature of OxyContin helped start the epidemic. “They promoted this drug heavily,” Blondell said. “I can remember representatives coming around with little bags, pens and clocks. They had a clock that just had 12 on there to remind us to prescribe it every 12 hours. The older physicians said, ‘Boy don’t listen to them. They don’t know what they’re talking about, these are addictive drugs,’ — and it turns out those old, family doctors were right.” Dr. Steven Aks, immersive physician and head of toxicology at Cook County Health, said it’s important to distinguish that there are two “faces” to the current opioid epidemic: pharmaceutical pills and street drugs.

Read More

CCA Shows Success in Managing Members’ Pain and Opioid Use

Managed Healthcare Executive | November 11, 2019

The United States is battling an opioid crisis, and it is critically important that healthcare organizations do what they can to identify patients at high risk of suffering from the negative effects of this form of pain management. One organization addressing this issue is Commonwealth Care Alliance (CCA), a not-for-profit healthcare organization that serves more than 32,000 low-income, disabled, and elderly patients across Massachusetts who are dually eligible for Medicare and Medicaid. These individuals are often referred to as “super-users” of the healthcare system, as they make up only 5% of the population but account for about half of healthcare spending. Because of their complex patient profile, 20% of CCA members take opioid medications—a number much greater than the general population. This high rate, combined with the inherent challenges associated with managing pain and care with opioids, led to the creation of CCA’s statewide High Opioid Patient Engagement (HOPE) program, which manages the risk of overdose and reduced opioid dependence among members.

Read More

Opioid Addiction Can be Controlled Using an In-Brain Chip Technology: First U.S. Clinical Trial

LabRoots | November 06, 2019

Opioid addiction is a chronic disease that can cause significant health, social, and economic problems. Opioids are a class of drugs that act in the nervous system to produce feelings of pleasure and pain relief. The overdose of opioids negatively affects a person's personal and professional relationships. Some opioids are legally prescribed by healthcare providers to manage severe and chronic pain. According to the US Department of Health & Human Services, there were 47,600 of opioids overdose deaths, and more than130 people died from opioid-related drug overdoses in 2016 and 2017. Researchers in China conducted the first clinical trial of DBS for methamphetamine addiction at Shanghai's Ruijin Hospital in China, along with tests for opioid addicts. The patients are resistant to the various treatments for opioid addiction. Researchers at the West Virginia University Rockefeller Neuroscience Institute (RNI) and West Virginia University Medicine are conducting the first clinical trial in the US that uses deep brain stimulation (DBS) to treat opioid addiction.

Read More

Purdue Pharma settlements a window into U.S. opioid crisis

The DePaulia | October 21, 2019

After more than 2,600 lawsuits nationwide involving their role in the opioid epidemic sweeping through the country, Purdue Pharma — the manufacturer of prescription painkiller OxyContin — filed for bankruptcy Sept. 16. In 2017, opioids were responsible for 47,600 of the 70,237 U.S. drug overdose deaths — with more than 28,000 of these opioid-related deaths being attributed to synthetic opioids, such as fentanyl. From 1999 to 2017, more than 400,000 Americans have died from opioid overdoses. The declaration of bankruptcy followed a tentative $10 to $12 billion settlement with 27 states and thousands of cities and counties throughout the nation — with nearly 20 other states rejecting the terms of the settlement. Dr. Richard Blondell, physician and vice chair for addiction medicine at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, said the company’s heavy marketing downplaying the addictive nature of OxyContin helped start the epidemic. “They promoted this drug heavily,” Blondell said. “I can remember representatives coming around with little bags, pens and clocks. They had a clock that just had 12 on there to remind us to prescribe it every 12 hours. The older physicians said, ‘Boy don’t listen to them. They don’t know what they’re talking about, these are addictive drugs,’ — and it turns out those old, family doctors were right.” Dr. Steven Aks, immersive physician and head of toxicology at Cook County Health, said it’s important to distinguish that there are two “faces” to the current opioid epidemic: pharmaceutical pills and street drugs.

Read More

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