Groundbreaking blood test detects fibromyalgia

| March 18, 2019

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New research finds an accurate way of diagnosing fibromyalgia and differentiating it from other related conditions. Using blood samples and innovative techniques, scientists have detected a "molecular fingerprint" that is unique to the condition. Fibromyalgia is a chronic condition that affects 2–8 percent of the worldwide population and approximately 4 million adults in the United States. Most of the people living with fibromyalgia are women.

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Braeburn Care Ltd

At Braeburn Care we provide a wide range of care at home services, offering a complete support service that is tailored to individual needs. Currently covering areas around West Kent including Tunbridge Wells, Crowborough, Tonbridge, Hildenborough, Southborough, Paddock Wood and surrounding areas offering individuals a real alternative to residential care. In line with CQC legislation and guidelines at Braeburn Care we are committed to supporting independence and personal freedom by providing the high quality care individuals may require to remain safely at home, and by providing service with compassion we also give the confidence to family and loved ones that our customers are receiving the highest standard of care. Whether our customers require either short-term or longer term personal care, companionship, overnight, daily or weekly visits, emergency or respite care or 24 hour live-in care, our team at Braeburn Care can provide a complete care solution to meet their individua

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New Dimensions of Clinical Trial Optimization

Article | April 20, 2021

For much of the past three decades, even as methodologies for clinical trial design have advanced and refined, the idea of the optimized clinical trial has centered on optimal patient samples, target enrollment rates, and generally the most efficient uses of scarce resources in the form of patients. Yet anyone who has had to design and optimize a clinical trial, knows that trial optimization occurs within an ecosystem of choices; a series of choices that stretch from the time it takes to implement a clinical trial and submit clinical data for analysis, to general concerns about the cost and power of a clinical trial. A true clinical trial optimization process would try to unify a number of these choices into a single framework for trial optimization. The complexity of clinical trial optimization comes from the need to align priorities on the one hand, and to understand opportunities on the other. We know that at a very general level, clinical operations specialists benefit from simplicity in clinical trial design, and that commercial teams prefer shorter clinical trials to longer ones. We also know that the statistical design of a clinical trial can influence both simplicity and duration. Yet how many sponsors have their clinical operations and commercial teams, sit with their R&D teams to review various statistically nuanced design options? For many sponsors, the reason this process does not occur as often as it should, is because the nuanced statistical parameters of a clinical trial design are very difficult to communicate to non-statisticians. Yet a trial optimization tool like Solara, equipped with data visualizations and the ability to see tradeoffs intuitively, can overcome this challenge. The real challenge is often convincing the non-statistician that they have a stake in clinical trial design. Cytel recently had a client that thought it needed a sample size re-estimation design, because it had a very strict limit on the number of patients it could enroll. After a few hours of working with Solara, though, a statistician discovered that a much simpler Group Sequential Design would deliver comparable power using about the same number of patients. The gains from the more complex design were minimal from the optimization perspective, when understood as the eco-system of choices. Similarly, most commercial teams pressure their clinical trial designers to have the most accelerated clinical trial imaginable, but as we all know, the longer the clinical trial the more likely there will be a higher number of events that demonstrate the effectiveness of a new medicine. So commercialization teams have a stake in longer clinical trials, even when their rule of thumb is to shorten them. Therefore, it is absolutely essential to communicate the benefits of various statistical designs to multiple stakeholders in a way that makes tradeoffs clear. Aligning on priorities early during the clinical trial design process is essential to selecting the optimal clinical trial. Yet for this statisticians need to be equipped for both a strategic and communicative role in the R&D process.

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PHARMACY MARKET

A pharma outsourcing mission

Article | April 20, 2021

In a way, getting through the initial stages of a complex pharmaceutical project that is being outsourced to a contract development and manufacturing organization is like getting a rocket off the ground. Many drug developers express frustration with the time it often takes during the initial stages of working with a CDMO — from the time they first reach out to a CDMO for help until they receive a proposal. Some have described it as months of silence from when they send a request for proposal (RFP) until they have a proposal in hand. The initial stages of a relationship between drug sponsor and CDMO often do not get the attention it deserves, and valuable time is lost, delaying projects and delaying delivery of therapeutics to patients. The quick scheduling of the ACT meeting with the right attendees can deliver immediate answers to key questions needed by the drug sponsor for effective planning and can help propel projects to a successful launch.

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How Can Medical Cannabis Help to Manage Pain Conditions? – The Cannabis Exchange

Article | April 20, 2021

Pain management is one of the most common reasons for the use of medical cannabis products. However, despite many jurisdictions – including Canada, Germany, and the Netherlands – now allowing the prescription of medical cannabis for this purpose, there remains little ‘high-quality’ evidence to support, or oppose its efficacy. Madden et al. (2018) set out to review the evidence available in order to determine the efficacy of medical cannabis when employed in the management of various forms of musculoskeletal pain. The researchers analysed various studies that assessed the use of cannabinoids in the treatment of arthritis pain; back pain; postoperative pain; and trauma-related pain. It is estimated that up to 30% of the population may suffer from a non-cancer-related pain condition. As such a high percentage of people suffer from these conditions, the development of simple and safe therapies is an essential area of research. This is particularly important as the therapeutic options for people with chronic pain are increasingly limited.

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Advance Your Pharma Supply Chain Planning during a Pandemic

Article | April 20, 2021

One predominant and common element within our pharmaceutical industry, is our devotions to patients. Within supply chain there is always a focus on ensuring the right product is delivered to the right place at the right time in order to ensure patient safety and the continuity of medicinal supplies. With the spread of COVID-19 across 117 countries and counting, every supply chain needs to evaluate their global footprint and develop contingency plans within their end to end operations.

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Spotlight

Braeburn Care Ltd

At Braeburn Care we provide a wide range of care at home services, offering a complete support service that is tailored to individual needs. Currently covering areas around West Kent including Tunbridge Wells, Crowborough, Tonbridge, Hildenborough, Southborough, Paddock Wood and surrounding areas offering individuals a real alternative to residential care. In line with CQC legislation and guidelines at Braeburn Care we are committed to supporting independence and personal freedom by providing the high quality care individuals may require to remain safely at home, and by providing service with compassion we also give the confidence to family and loved ones that our customers are receiving the highest standard of care. Whether our customers require either short-term or longer term personal care, companionship, overnight, daily or weekly visits, emergency or respite care or 24 hour live-in care, our team at Braeburn Care can provide a complete care solution to meet their individua

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