Drug Screening: Cellular proliferation assay performed inside a mouse

KATRIN SCHLIE | November 21, 2018

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Although many new cellular assays entered the drug discovery scene over the course of the last decades, we still lack a predictable tool when it comes to selecting compounds or cell lines for xenograft testing. What is lacking? Cellular models do not account for the challenges the compounds face when injected in a mouse such as high serum concentration, the presence of inhibiting factors in the mouse or simple pharmacokinetic or biodistribution issues.

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Martindale Pharma

Martindale Pharma is an established UK-based specialty pharmaceutical company; unusually it has its own UK manufacturing base and a track record of supplying individualised or difficult to make medicines for clinicians and pharmacists.

OTHER ARTICLES

Clinical Development Risks and Issues in a COVID-19 World

Article | March 20, 2020

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Article | February 25, 2020

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Article | March 11, 2020

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How Can Medical Cannabis Help to Manage Pain Conditions? �� The Cannabis Exchange

Article | February 11, 2020

Pain management is one of the most common reasons for the use of medical cannabis products. However, despite many jurisdictions – including Canada, Germany, and the Netherlands – now allowing the prescription of medical cannabis for this purpose, there remains little ‘high-quality’ evidence to support, or oppose its efficacy. Madden et al. (2018) set out to review the evidence available in order to determine the efficacy of medical cannabis when employed in the management of various forms of musculoskeletal pain. The researchers analysed various studies that assessed the use of cannabinoids in the treatment of arthritis pain; back pain; postoperative pain; and trauma-related pain. It is estimated that up to 30% of the population may suffer from a non-cancer-related pain condition. As such a high percentage of people suffer from these conditions, the development of simple and safe therapies is an essential area of research. This is particularly important as the therapeutic options for people with chronic pain are increasingly limited.

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Spotlight

Martindale Pharma

Martindale Pharma is an established UK-based specialty pharmaceutical company; unusually it has its own UK manufacturing base and a track record of supplying individualised or difficult to make medicines for clinicians and pharmacists.

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