Drug compound could be next-generation treatment for aggressive form of AML

| January 29, 2019

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Purdue University researchers are developing a series of drug compounds that have shown promise in treating the recurrence of acute myeloid leukemia (AML). About 30 percent of acute myeloid leukemia (AML) patients have a mutation caused by a kinase called FLT3, which makes leukemia more aggressive. Inhibitors of FLT3, such as Radapt, approved last year by the US Food and Drug Administration, have shown a good initial response to treating leukemia. Gilteritinib, another FLT3 inhibitor, was recently approved toward the end of 2018. But AML patients on FLT3 inhibitor therapy often relapse because of secondary mutations in the FLT3 and existing treatments have not been fully successful in treating those cases.

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EvergreenHealth

EvergreenHealth, a public hospital district, is an integrated health care system offering a breadth of services and programs that is among the most comprehensive in the region. In addition to the 318-bed acute care hospital on EvergreenHealth’s main campus in Kirkland, which includes 24-hour Level III trauma emergency care and critical care, EvergreenHealth provides primary, urgent, and specialty care along with a 24/7 emergency department at its satellite EvergreenHealth Redmond Medical Center.

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Spotlight

EvergreenHealth

EvergreenHealth, a public hospital district, is an integrated health care system offering a breadth of services and programs that is among the most comprehensive in the region. In addition to the 318-bed acute care hospital on EvergreenHealth’s main campus in Kirkland, which includes 24-hour Level III trauma emergency care and critical care, EvergreenHealth provides primary, urgent, and specialty care along with a 24/7 emergency department at its satellite EvergreenHealth Redmond Medical Center.

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