Doctors love golf: Fact or fiction?

MARIA COHUT | December 11, 2018

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A long-lived stereotype about doctors is that they are avid golf players. In a new study, featured in the Christmas issue of The BMJ, specialists from the Harvard Medical School tackle this common belief head-on. Every year in the holiday season, the prestigious medical journal The BMJ publishes a special issue that takes the road less traveled by research, answering some of the questions that readers perhaps did not know they even had.

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United Family Healthcare

After 21 years of development, United Family Healthcare (UFH) now offers a complete range of medical services including sophisticated surgical and interventional solutions that match top hospitals around the world. A true pioneer in Asia’s healthcare development, we lead the way in international standards of service in high-end, private medical care. With 7 hospitals and 14 satellite clinics in Beijing, Shanghai, Guangzhou, Tianjin, Qingdao, Nanjing, Wuxi, Hangzhou and Bo'ao, UFH is recognized as one of the premium healthcare systems nationwide and is internationally accredited by the Joint Commission International (JCI). There are over 400 full-time doctors from 25 different countries and regions working in UFH. Additionally there are over 1100 part-time experts and over 900 nurses on the team.

OTHER ARTICLES

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That simple truth about the severity of the disease is one of the reasons that Rafael Pharmaceuticals is slowly continuing with a Phase III trial in metastatic pancreatic cancer during the COVID-19 pandemic. While many companies have paused enrollment in clinical trials during the outbreak, Cranbury, N.J,-based Rafael opted to continue to enroll patients in its Phase III AVENGER 500 study of its lead compound CPI-613 (devimistat) in combination with modified Folfirinox (mFFX) as first-line therapy for the disease. Sanjeev Luther, president and chief executive officer of Rafael Pharmaceuticals, told BioSpace that the company made the decision to continue to enroll the trial, which was 75% filled, due to the short timeline patients with metastatic pancreatic cancer have. After discussing the matter of the trial with the company’s leadership team, Luther said they felt comfortable leaving the decision of whether or not the trial should continue to the conducting institute.

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New Dimensions of Clinical Trial Optimization

Article | April 20, 2021

For much of the past three decades, even as methodologies for clinical trial design have advanced and refined, the idea of the optimized clinical trial has centered on optimal patient samples, target enrollment rates, and generally the most efficient uses of scarce resources in the form of patients. Yet anyone who has had to design and optimize a clinical trial, knows that trial optimization occurs within an ecosystem of choices; a series of choices that stretch from the time it takes to implement a clinical trial and submit clinical data for analysis, to general concerns about the cost and power of a clinical trial. A true clinical trial optimization process would try to unify a number of these choices into a single framework for trial optimization. The complexity of clinical trial optimization comes from the need to align priorities on the one hand, and to understand opportunities on the other. We know that at a very general level, clinical operations specialists benefit from simplicity in clinical trial design, and that commercial teams prefer shorter clinical trials to longer ones. We also know that the statistical design of a clinical trial can influence both simplicity and duration. Yet how many sponsors have their clinical operations and commercial teams, sit with their R&D teams to review various statistically nuanced design options? For many sponsors, the reason this process does not occur as often as it should, is because the nuanced statistical parameters of a clinical trial design are very difficult to communicate to non-statisticians. Yet a trial optimization tool like Solara, equipped with data visualizations and the ability to see tradeoffs intuitively, can overcome this challenge. The real challenge is often convincing the non-statistician that they have a stake in clinical trial design. Cytel recently had a client that thought it needed a sample size re-estimation design, because it had a very strict limit on the number of patients it could enroll. After a few hours of working with Solara, though, a statistician discovered that a much simpler Group Sequential Design would deliver comparable power using about the same number of patients. The gains from the more complex design were minimal from the optimization perspective, when understood as the eco-system of choices. Similarly, most commercial teams pressure their clinical trial designers to have the most accelerated clinical trial imaginable, but as we all know, the longer the clinical trial the more likely there will be a higher number of events that demonstrate the effectiveness of a new medicine. So commercialization teams have a stake in longer clinical trials, even when their rule of thumb is to shorten them. Therefore, it is absolutely essential to communicate the benefits of various statistical designs to multiple stakeholders in a way that makes tradeoffs clear. Aligning on priorities early during the clinical trial design process is essential to selecting the optimal clinical trial. Yet for this statisticians need to be equipped for both a strategic and communicative role in the R&D process.

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Coronavirus Pandemic Brings Hundreds Of U.S. Clinical Trials To A Halt

Article | April 11, 2020

Rene Roach fired off a quick email in late March for an update on a colorectal cancer clinical trial for which she hoped to qualify. Worried about the coronavirus, she asked, almost as an afterthought, whether the study had been put on hold because of the pandemic.The answer crushed her: It had been. "That's when COVID-19 shut down everything," says Roach, 50, of Germantown, Md. Roach assumed that there would be workarounds for patients like her, who have stage IV cancer. These patients often depend on clinical trials as their best chance to knock cancer out when other therapies have failed. For now, she's being treated with traditional chemotherapy, but she was counting on the drug cocktail from the clinical trial. She figures if chemo was going to rid her body of cancer for good, it would have done so already.

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Spotlight

United Family Healthcare

After 21 years of development, United Family Healthcare (UFH) now offers a complete range of medical services including sophisticated surgical and interventional solutions that match top hospitals around the world. A true pioneer in Asia’s healthcare development, we lead the way in international standards of service in high-end, private medical care. With 7 hospitals and 14 satellite clinics in Beijing, Shanghai, Guangzhou, Tianjin, Qingdao, Nanjing, Wuxi, Hangzhou and Bo'ao, UFH is recognized as one of the premium healthcare systems nationwide and is internationally accredited by the Joint Commission International (JCI). There are over 400 full-time doctors from 25 different countries and regions working in UFH. Additionally there are over 1100 part-time experts and over 900 nurses on the team.

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