Discriminating insulin analogs with liquid chromatography-mass spectrometry

| April 4, 2018

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There is currently a half-dozen different insulin analogues on the market. These differ from each other and from natural insulin by just a few amino acids but exhibit markedly different pharmacokinetic and pharmacodynamic properties. Liquid chromatography and mass spectrometry (LC-MS) offers a powerful tool for the sensitive and quantitative detection and discrimination of these highly similar recombinant proteins. This whitepaper reviews the considerations that analytical chemists should take into account when planning to undertake the LC-MS analysis of an insulin analog-containing specimen.

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OTHER ARTICLES

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Polpharma

As a leading producer of generic drugs in Central and Eastern Europe, Russia and Kazakhstan, we create many opportunities for our employees to realize their full professional potential. We offer excellent prospects for career development in an international environment.

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