Clinical relevance of BCRP inhibition in causing drug-drug interactions (DDIs)

ROB ELSBY | January 26, 2016

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A recent research paper published in the journal of Drug Metabolism & Disposition and co-authored by Dr Rob Elsby, the Head of Cyprotex’s Drug Transporter Team, has confirmed the important role that solitary inhibition of the intestinal BCRP efflux transporter plays towards causing clinically observed DDIs with BCRP substrates such as rosuvastatin.

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Benchmark Vaccines Limited

We are a contract manufacturing business focused on animal health vaccines. The scope of services includes process development through to full commercial manufacture of licenced vaccines in our EU GMP approved facility. Our current customers include the animal health divisions of several international pharmaceutical companies. Our manufacturing operation was established in 1977 and was acquired in 2012 by Benchmark Vaccines Ltd (BVL) part of the Benchmark group of companies. We are located in Braintree in the United Kingdom less than 25km from London’s Stansted airport.

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