Can we halt cellular aging? New drug combo shows promise

| February 20, 2019

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Aging cells can become toxic to surrounding tissue, thus leading to numerous health problems. A class of drugs scientists calls senolytics could help address these health issues, and improve symptoms. Senolytics are a class of drugs that target cells that have entered senescence, meaning an old age stage that renders them toxic to surrounding, healthy cells.

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Idifarma Desarrollo Farmacéutico, S.L.

Idifarma is a leading Contract Development Organization for the pharmaceutical and biotechnology industries. Based in Spain, but with an increasingly international reach, Idifarma provides a full range of services that encompasses: drug formulation, development and validation of analytical methods, quality control and batch release in the EU, Pilot-Scale GMP-compliant manufacturing, ICH stability studies, clinical trial logistics management and regulatory support. Now, we can also manufacture commercial batches of high potency and conventional oral solids.

OTHER ARTICLES

Pfizer Won’t Win the Coronavirus Pharma War

Article | March 6, 2020

Shares of Pfizer jumped more than 6% on Wednesday, after the company announced a plan to test some of its antiviral products as a potential treatment for the coronavirus from China. More than 35 million shares traded on the news — about 48% more than normal — as investors looked for any positive news from the pharma community after the recent selloff. So, does this mean that Pfizer stock is turning the corner?

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How pharma can continue engaging HCPs in a world gripped by COVID-19

Article | April 10, 2020

Medscape is the leading source of clinical news, health information, and point-of-care tools for healthcare professionals. Medscape offers specialists, primary care physicians, and other health professionals the most robust and integrated medical information and educational tools. Medscape Education (medscape.org) is the leading destination for continuous professional development, consisting of more than 30 specialty-focused destinations offering thousands of free CME and CE courses and other educational programmes for physicians, nurses, and other healthcare professionals. Both Medscape and Medscape Education are part of WebMD Health Corp., an Internet Brands company. Face-to-face interactions between pharma and physicians have essentially ceased overnight during the COVID-19 pandemic, but that doesn’t mean HCPs have stopped looking for new medical information.

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As Pandemic Continues, Rafael Pharmaceuticals Enrolls Patients in Phase III Pancreatic Cancer Trial

Article | April 17, 2020

That simple truth about the severity of the disease is one of the reasons that Rafael Pharmaceuticals is slowly continuing with a Phase III trial in metastatic pancreatic cancer during the COVID-19 pandemic. While many companies have paused enrollment in clinical trials during the outbreak, Cranbury, N.J,-based Rafael opted to continue to enroll patients in its Phase III AVENGER 500 study of its lead compound CPI-613 (devimistat) in combination with modified Folfirinox (mFFX) as first-line therapy for the disease. Sanjeev Luther, president and chief executive officer of Rafael Pharmaceuticals, told BioSpace that the company made the decision to continue to enroll the trial, which was 75% filled, due to the short timeline patients with metastatic pancreatic cancer have. After discussing the matter of the trial with the company’s leadership team, Luther said they felt comfortable leaving the decision of whether or not the trial should continue to the conducting institute.

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What do you have to lose taking hydroxychloroquine for coronavirus? Potentially your life

Article | April 10, 2020

The president and some of his close advisors — desperate for a COVID-19 cure — are asking “What do you have to lose?” by taking hydroxychloroquine (HCQ), a strong medication never adequately tested for efficacy or safety in COVID-19 patients. The correct answer to the president’s question, which he doesn’t seem to want to hear, is that we have our lives to lose. The president acknowledges “I’m not a doctor” but this raises the question “What do doctors know about the drug recommended by the president? Most doctors are aware that HCQ can be effective for patients with malaria, arthritis or lupus. If they were to follow the president’s suggestion and prescribe it for COVID-19 patients, they would also like to know that it will benefit some of those patients, at least.

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Spotlight

Idifarma Desarrollo Farmacéutico, S.L.

Idifarma is a leading Contract Development Organization for the pharmaceutical and biotechnology industries. Based in Spain, but with an increasingly international reach, Idifarma provides a full range of services that encompasses: drug formulation, development and validation of analytical methods, quality control and batch release in the EU, Pilot-Scale GMP-compliant manufacturing, ICH stability studies, clinical trial logistics management and regulatory support. Now, we can also manufacture commercial batches of high potency and conventional oral solids.

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