Bacterial evolution of antibiotic arsenals provides new drug blueprints

| February 7, 2020

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Scientists from Trinity College Dublin have discovered that two very different species of bacteria have evolved distinct, powerful antibiotic arsenals for use in the war against their bacterial neighbours. By blueprinting precisely how the antibiotics function against methicillin-resistant Staphylococcus aureus (MRSA), the scientists have provided new options for drug designers seeking to hold back the global threat that antimicrobial resistance poses humanity. Failure to develop effective antibiotics that counter resistance to current drugs will have disastrous consequences. It is estimated that by mid-century, just 30 years from now, antimicrobial resistance will result in a global death rate of up to 10 million per year. By 2030, the World Bank puts the cost of resistance at US$3.4 trillion in global gross domestic product. The need for new and effective therapeutics is immediate and immense. The hope is that the basic research into the workings of an enzyme involved in bacterial coat synthesis reported in this article will contribute to the development of these urgently needed medicines.

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Eisai Inc. was established in 1995 and began marketing its first product in the United States in 1997. Since then we have rapidly grown to become a fully integrated pharmaceutical business. Eisai’s areas of commercial focus include neurology, gastrointestinal disorders and oncology/critical care. The company serves as the U.S. pharmaceutical operation of Eisai Co., Ltd., a research-based human health care (hhc) company that discovers, develops and markets products throughout the world.

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Spotlight

Eisai US

Eisai Inc. was established in 1995 and began marketing its first product in the United States in 1997. Since then we have rapidly grown to become a fully integrated pharmaceutical business. Eisai’s areas of commercial focus include neurology, gastrointestinal disorders and oncology/critical care. The company serves as the U.S. pharmaceutical operation of Eisai Co., Ltd., a research-based human health care (hhc) company that discovers, develops and markets products throughout the world.

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