Aqueous solubility-enhancing excipient technologies: a review of recent developments

| February 16, 2018

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The pharmaceutical discovery process can vary significantly depending on the characteristics of the intended target and therapeutic indication, availability of compounds with suitable properties to hit the target, and robustness of in vitro assays, among other differences. Irrespective of these differences, at some point in the discovery process the newly synthesised compounds will be dosed to animals to determine their pharmacological and toxicological activity in vivo. This is the point at which their aqueous solubility often becomes important. Occasionally, this realisation will occur during in vitro studies, but poor aqueous solubility is usually masked by the nature of these assays.

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