Anti-CRISPR Proteins Could Improve Gene Editing Precision

| February 8, 2019

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A research group in Denmark has found proteins in gut and soil microbes that can inhibit the action of CRISPR-Cas9 gene editing, a finding that could help to control the technology with more precision and less risk. Bacteria and viruses have fought an evolutionary arms race for millions of years. Bacteria evolved CRISPR systems to combat invading viruses, called bacteriophages, by cutting out the viral DNA from the bacterial genome. These systems have formed the basis of groundbreaking gene editing tools today such as CRISPR-Cas9. However, less well studied is the viral way of disarming the defense system, anti-CRISPR proteins.

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AgeneBio

AgeneBio, Inc., is an emerging pharmaceutical company dedicated to developing innovative therapeutics that prevent neurodegeneration and preserve and restore cognitive function for unserved patients battling amnestic mild cognitive impairment (aMCI), the symptomatic pre-dementia stage of Alzheimer’s disease, and other neurological and psychiatric diseases.

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Spotlight

AgeneBio

AgeneBio, Inc., is an emerging pharmaceutical company dedicated to developing innovative therapeutics that prevent neurodegeneration and preserve and restore cognitive function for unserved patients battling amnestic mild cognitive impairment (aMCI), the symptomatic pre-dementia stage of Alzheimer’s disease, and other neurological and psychiatric diseases.

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