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As Pandemic Continues, Rafael Pharmaceuticals Enrolls Patients in Phase III Pancreatic Cancer Trial AS PANDEMIC CONTINUES, RAFAEL PHARMACEUTICALS ENROLLS PATIENTS IN PHASE III PANCREATIC CANCER TRIAL

article

Apr 17, 2020

That simple truth about the severity of the disease is one of the reasons that Rafael Pharmaceuticals is slowly continuing with a Phase III trial in metastatic pancreatic cancer during the COVID-19 pandemic. While many companies have paused enrollment in clinical trials during the outbreak, Cranbury...

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Roche Prepares to Launch COVID-19 Antibody Test System ROCHE PREPARES TO LAUNCH COVID-19 ANTIBODY TEST SYSTEM

article

Apr 17, 2020

Swiss pharma giant Roche is joining the race to develop a test for COVID-19 antibodies in people who have been exposed to the disease. This morning, Roche announced the development and upcoming launch of its Elecsys Anti-SARS-CoV-2 serology test to detect antibodies in people who have been exposed t...

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Coronavirus Pandemic Brings Hundreds Of U.S. Clinical Trials To A Halt CORONAVIRUS PANDEMIC BRINGS HUNDREDS OF U.S. CLINICAL TRIALS TO A HALT

article

Apr 11, 2020

Rene Roach fired off a quick email in late March for an update on a colorectal cancer clinical trial for which she hoped to qualify. Worried about the coronavirus, she asked, almost as an afterthought, whether the study had been put on hold because of the pandemic.The answer crushed her: It had been...

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How pharma can continue engaging HCPs in a world gripped by COVID-19 HOW PHARMA CAN CONTINUE ENGAGING HCPS IN A WORLD GRIPPED BY COVID-19

article

Apr 10, 2020

Medscape is the leading source of clinical news, health information, and point-of-care tools for healthcare professionals. Medscape offers specialists, primary care physicians, and other health professionals the most robust and integrated medical information and educational tools. Medscape Education...

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What do you have to lose taking hydroxychloroquine for coronavirus? Potentially your life WHAT DO YOU HAVE TO LOSE TAKING HYDROXYCHLOROQUINE FOR CORONAVIRUS? POTENTIALLY YOUR LIFE

article

Apr 10, 2020

The president and some of his close advisors — desperate for a COVID-19 cure — are asking “What do you have to lose?” by taking hydroxychloroquine (HCQ), a strong medication never adequately tested for efficacy or safety in COVID-19 patients. The correct answer to the preside...

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Global Antiviral Drugs Market Growth: Is Antiviral Drug the Best Coronavirus Treatment? GLOBAL ANTIVIRAL DRUGS MARKET GROWTH: IS ANTIVIRAL DRUG THE BEST CORONAVIRUS TREATMENT?

article

Apr 09, 2020

The global antiviral drugs market has witnessed a rapid surge in demand due to the ongoing Covid-19 pandemic worldwide. So is antiviral drug the best coronavirus treatment? It is still too early to have that conclusion as many medical research and clinical trials are still trying to find the effecti...

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A safer ride: the latest innovation in targeted cancer treatment A SAFER RIDE: THE LATEST INNOVATION IN TARGETED CANCER TREATMENT

article

Nov 28, 2019

One downside of the antibody-drug conjugates used in oncology today is that the drug-carrying antibodies can shed much of their toxic cargo on the way to the tumour site. Now, German researchers have published their method for attaching drugs to antibodies with greater stability, potentially making ...

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Searching Chemical Spaces to Boost Drug Development SEARCHING CHEMICAL SPACES TO BOOST DRUG DEVELOPMENT

article

Nov 20, 2019

In drug discoverers’ jargon, large collections of molecules are known as chemical spaces. Whereas chemical spaces only contained a few million molecules some years ago, they now hold tens of billions of molecules. In addition, previously “virtual” molecules can now be purchased and...

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What lower prices would mean for drug companies? WHAT LOWER PRICES WOULD MEAN FOR DRUG COMPANIES?

article

Nov 15, 2019

Drug pricing regulations would not decimate the pharmaceutical industry, according to an analysis from health policy researchers at West Health and Johns Hopkins. This throws some cold water on Big Pharma's claims that new drug research and investments would evaporate if the federal government l...

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Mistakes to Be Avoided When Preparing a Drug Launch MISTAKES TO BE AVOIDED WHEN PREPARING A DRUG LAUNCH

article

Nov 05, 2019

The launch of a new product can be a daunting task. The main reason this happens is that no matter how many times your company has managed to enter new products on the market, chances are that not one initiative entirely resembled another. For better or for worse, there is not a single recipe for su...

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Drug Helps Plants Resist Drought: Study DRUG HELPS PLANTS RESIST DROUGHT: STUDY

article

Oct 24, 2019

An engineered small molecule called opabactin that targets the receptor for the hormone abscisic acid (ABA), which plants release in stressful conditions, limited water loss in Arabidopsis, tomato, and wheat, and improved wheat’s tolerance of drought-like conditions in the lab, according to a ...

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Mulesoft: how can API tools speed up drug development? MULESOFT: HOW CAN API TOOLS SPEED UP DRUG DEVELOPMENT?

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Oct 24, 2019

At its Connect conference in London in early October, MuleSoft brought together its customers and clients across all sectors to discuss how enterprise software, and particularly APIs, can drive efficiencies and contribute to digital transformation. Mulesoft’s David Chao and AstraZeneca’s...

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Drug Delivery DRUG DELIVERY

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Oct 23, 2019

A drug’s efficacy can be impacted significantly by the way in which it is delivered. By developing a variety of drug delivery systems (DDSs) it is now possible to better control the pharmacokinetics, pharmacodynamics, toxicity, immunogenicity and efficacy of drugs. By finding the best-suited d...

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IoT and Drug Adherence: Different Approaches to Connected Solutions IOT AND DRUG ADHERENCE: DIFFERENT APPROACHES TO CONNECTED SOLUTIONS

article

Oct 11, 2019

Sometimes it’s the really small things that make a huge difference to a person’s health. Skipping dosages of prescription medication, for example, has been linked to an array of negative effects. About half of us are guilty of not taking medication correctly, according to figures shared ...

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DRUG PRICES KILLING OR DISEASES? DRUG PRICES KILLING OR DISEASES?

article

Oct 10, 2019

The United States is a huge economy and the economies look up to it for inspiration on how to manage the country to yield maximum output from the economy. But the medicines and drugs in the country are something that has always been on the controversial aspects of the country.

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Demonstrating drug potency early in cell therapy development DEMONSTRATING DRUG POTENCY EARLY IN CELL THERAPY DEVELOPMENT

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Oct 07, 2019

With traditional drug development, the FDA typically focuses the majority of its attention on clinical aspects of a drug. With advanced cell and gene therapies, the agency places far more focus on chemistry manufacturing and controls (CMC) much earlier in development. Due in part to the fact that th...

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Shortage of drugs having a serious impact on primary care SHORTAGE OF DRUGS HAVING A SERIOUS IMPACT ON PRIMARY CARE

article

Oct 07, 2019

According to information gleaned from a drug tracker, more than 100 drugs regularly prescribed by GPs are now out of stock, and this is forcing patients to ‘chop and change’ between medicines. The tracker showed that a total of 106 products were unavailable earlier this month, while a fu...

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The 10 latest FDA Orphan Drug Designations for cancer treatments THE 10 LATEST FDA ORPHAN DRUG DESIGNATIONS FOR CANCER TREATMENTS

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Sep 25, 2019

The FDA grants Orphan Drug Designation to treatments for rare diseases in R&D; here are the 10 most recent for oncologic conditions. The US Food and Drug Administration’s (FDA) Orphan Drug Designation (ODD) denotes medications that are potential promising treatments for rare diseases in th...

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How does a drug for colorectal cancer work? HOW DOES A DRUG FOR COLORECTAL CANCER WORK?

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Sep 25, 2019

Colorectal cancer is a fatal and common disease, and treatment decisions are often based on what genes have been mutated in the development of the cancer. This means that certain patients with colorectal cancer may benefit from the chemotherapeutic ‘cetuximab’ while other patients may be...

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Could smart pill bottles dispense a solution to drug non-adherence? COULD SMART PILL BOTTLES DISPENSE A SOLUTION TO DRUG NON-ADHERENCE?

article

Sep 25, 2019

To tackle the challenge of medication adherence, particularly in the clinical trial space, UK health tech company Elucid has created a smart pill bottle and mobile app called Pill Connect. Currently in the trial stage, Pharma Tech Focus talks to Elucid’s CEO Dr James Burnstone about how the sy...

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Reviving a Discontinued Drug REVIVING A DISCONTINUED DRUG

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Sep 24, 2019

Most of the drugs that are taken off the market are removed for reasons other than safety. However, sometimes drug makers choose to remove drugs from the market even if there is no problem with their safety profile. In fact, from 1994 through 2015, 215 drugs were withdrawn from sale, and only 5.1 pe...

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AI and Drug Discovery, Protecting the Value of Data in Collaborations AI AND DRUG DISCOVERY, PROTECTING THE VALUE OF DATA IN COLLABORATIONS

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Sep 23, 2019

AI and Pharma update, Melloddy project—a ground-breaking collaboration between pharmaceutical companies, technology companies, and academic institutions to accelerate drug discovery by sharing pharmaceutical industry data. As we explained, the Melloddy project uses federated learning and block...

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Immigrants Buying Meds on the Street: A Problem of High Drug Prices and Fears of Deportation IMMIGRANTS BUYING MEDS ON THE STREET: A PROBLEM OF HIGH DRUG PRICES AND FEARS OF DEPORTATION

article

Sep 20, 2019

A lot of media coverage about counterfeit drug threats in the U.S. are spurred by the media relations efforts of organizations funded by pharmaceutical companies, such as the Alliance for Safe Online Pharmacies and Partnership for Safe Medicines. As I see it, their public education efforts conflate ...

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Zolgensma – more than just the world’s most expensive drug ZOLGENSMA – MORE THAN JUST THE WORLD’S MOST EXPENSIVE DRUG

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Sep 19, 2019

The US Food and Drug Administration (FDA) recently approved Zolgensma, Novartis’ one-dose gene therapy for the treatment of paediatric patients (less than two years of age) suffering from spinal muscular atrophy (SMA), a rare but life-threatening disease. Zolgensma was acquired by Novartis as ...

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US finds contaminant in popular heartburn drug US FINDS CONTAMINANT IN POPULAR HEARTBURN DRUG

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Sep 13, 2019

U.S. health officials are investigating low levels of a potentially dangerous contaminant in the popular heartburn medication Zantac and related drugs. FDA officials said the amount of the contaminant barely exceeds levels found in common foods. But the same chemical has been linked to dozens of rec...

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It’s Time For Congress To Go All In On Drug Pricing Reform IT’S TIME FOR CONGRESS TO GO ALL IN ON DRUG PRICING REFORM

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Sep 06, 2019

The partisan stars are appear to be aligned in Washington on passing federal drug pricing reform, but not without its share of political fits and starts. The latest proposal to suffer a setback has been Trump’s rebate rule, a clear signal that the Administration has pushed about as far as it c...

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The promise and pitfalls of serial femtosecond X-ray crystallography THE PROMISE AND PITFALLS OF SERIAL FEMTOSECOND X-RAY CRYSTALLOGRAPHY

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Sep 04, 2019

A report from scientists at the Moscow Institute of Physics and Technology highlights the advantages and disadvantages of serial femtosecond X-ray crystallography. This article investigates the review, focusing on its role in drug development. The article delves into the reasons behind the researche...

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A Field Manual For The Battle Over HIV Prevention Drug Pricing A FIELD MANUAL FOR THE BATTLE OVER HIV PREVENTION DRUG PRICING

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Aug 29, 2019

Pre-exposure prophylaxis (PrEP) an HIV prevention intervention consisting of a daily drug cocktail, quarterly HIV/sexually transmitted disease screening, and laboratory monitoring—has repeatedly been shown to be safe, effective, and cost-effective. Although US guidelines have recommended PrEP ...

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Prescription 2020: Democratic Candidates And Drug Pricing PRESCRIPTION 2020: DEMOCRATIC CANDIDATES AND DRUG PRICING

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Aug 29, 2019

Prescription drug pricing appears poised to be an important issue in the 2020 presidential election. Identified as Americans’ top health care priority for the new Congress in 2019, the rising cost of prescription drugs has occupied an increasingly prominent place in national discourse. Perhaps...

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Why It’s So Difficult to Reduce Drug Prices WHY IT’S SO DIFFICULT TO REDUCE DRUG PRICES

article

Aug 28, 2019

Partly because it’s an election year and partly because, well, drugs can be expensive, the topic of drug pricing is a hot-button issue. Earlier this year, in February, seven pharmaceutical executives were grilled by the U.S. Senate Finance Committee over drug pricing. The tone was set by U.S. ...

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Drug-Resistant Salmonella Linked to Overuse of Antibiotics in Cattle Farming DRUG-RESISTANT SALMONELLA LINKED TO OVERUSE OF ANTIBIOTICS IN CATTLE FARMING

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Aug 23, 2019

The Centers for Disease Control and Prevention (CDC) warned Thursday of a drug-resistant strain of salmonella newport linked to the overuse of antibiotics in cattle farming. The strain sickened 255 people in 32 states between June 2018 and March 2019, leading to 60 hospitalizations and two deaths, t...

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Marijuana is getting more popular in America while cocaine declines MARIJUANA IS GETTING MORE POPULAR IN AMERICA WHILE COCAINE DECLINES

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Aug 23, 2019

Illicit drug use lurks in the shadows one reason its difficult to study. But public health researchers pull together numbers from surveys, overdose records and other sources to look for trends in how much people spend on drugs, numbers of users and frequency of use that can help policy makers fight ...

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Random Drug and Alcohol Testing With Precede RANDOM DRUG AND ALCOHOL TESTING WITH PRECEDE

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Aug 22, 2019

Random Drug and Alcohol Testing can effectively detect substance abuse in the workplace, ultimately helping keep employees safe and healthy in the workplace. More and more companies are using Random Testing as a method of reducing workplace incidents, and as an extra precaution if experiencing an in...

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Can CBD be Used to Treat Drug Addiction? CAN CBD BE USED TO TREAT DRUG ADDICTION?

article

Aug 22, 2019

There is a growing debate over the statutory medical use of marijuana and cannabinoids. Whilst there have been documented successful uses of cannabis and its derivatives in a medical context, concerns remain about its short-term and long-term side-effects including potential drug dependency and the ...

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Alzheimers drug reverses brain damage due to underage drinking ALZHEIMERS DRUG REVERSES BRAIN DAMAGE DUE TO UNDERAGE DRINKING

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Aug 20, 2019

Duke researchers show that alcohol induced brain damage in adolescents can be reversed using a drug prescribed for Alzheimers. A drug used to slow cognitive decline in Alzheimers disease could reverse alcohol induced brain damage. Brain inflammation and neuron damage in rats exposed to alcohol durin...

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Morally corrupt drug pricing policy hurts black LGBTQ community the most MORALLY CORRUPT DRUG PRICING POLICY HURTS BLACK LGBTQ COMMUNITY THE MOST

article

Aug 19, 2019

Lowering prescription drug prices was a rallying cry for politicians in last years midterm election, and people came out in droves to support candidates who promised action on this front. Drug pricing, as well as the broader issue of crippling health care costs, cuts across lines that divide liberal...

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Bio-Inspired Nanomedicine An Emerging Trend For Drug Targeting Into Cancer Cells BIO-INSPIRED NANOMEDICINE AN EMERGING TREND FOR DRUG TARGETING INTO CANCER CELLS

article

Aug 14, 2019

The mortality rate increases day-to-day due to most vulnerable disease cancer universally and current therapeutic mitigation bears high levels of diversity and complexity in therapeutic regime. The systemic application of chemotherapeutic agents often accompanied with serious side and adverse effect...

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Drug Testing in the Workplace DRUG TESTING IN THE WORKPLACE

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Aug 12, 2019

Drug testing can be quite a difficult and time-consuming policy to establish. Remember, an organisation must have consent from its employees to test them for drugs. This consent is usually included in the individual’s contract. The law imposes various requirements on employers who wish to unde...

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The Warning Signs of Alcohol Addiction THE WARNING SIGNS OF ALCOHOL ADDICTION

article

Aug 12, 2019

The prevalence of alcohol-related driving fatalities is also well-documented. The NSDUH reported almost 10,000 such deaths in 2014, accounting for 31 Percent of all driving fatalities that year. And traffic deaths are just one of the potential life-threatening outcomes of alcohol overconsumption. Ac...

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Party Drug vs. Medical Success PARTY DRUG VS. MEDICAL SUCCESS

article

Aug 09, 2019

For one, the price. Having been around for decades, Ketamine wasnt expensive. Second, Ketamines effect was unique, unlike the highs-lows of previous party drugs, Ketamine created a physical and psychological dissociation from self. Given its low price and unique effect, Ketamine instantaneously beca...

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Responsibilities under the Drug Supply Chain Security Act- Is your pharmacy compliant? RESPONSIBILITIES UNDER THE DRUG SUPPLY CHAIN SECURITY ACT- IS YOUR PHARMACY COMPLIANT?

article

Aug 02, 2019

Have you heard of the Drug Supply Chain Security Act, and do you realize how it is already impacting your pharmacy operation? This post kicks off a blog series Preparing for Track and Trace that will help you understand the ins and outs of the legislation and what it means for your business.

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Innovations in Drug Delivery System – Injectables INNOVATIONS IN DRUG DELIVERY SYSTEM – INJECTABLES

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Jul 29, 2019

The biologics drug development has stimulated innovations in novel injectable drug delivery systems. The conventional intravenous I.V. formulation is not suitable for biologics delivery due to its high viscosity, higher dosage volume, higher molecule size, protein stability issues and the need for t...

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The Latest on Drug Patent Scams THE LATEST ON DRUG PATENT SCAMS

article

Jul 19, 2019

HOW BIG PHARMA’S ANTI-COMPETITIVE PRACTICES DRIVE UP COSTS FOR EVERYBODY, WHILE AT THE SAME TIME STIFLING THE R & D THAT HIGH DRUG PRICES ARE SUPPOSED TO FUND. By now, most Americans understand that generic drugs and other biosimilars are not only safe, but tried-and-true. About three-quar...

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Ruling Reversed on Prescription Drug Rebate RULING REVERSED ON PRESCRIPTION DRUG REBATE

article

Jul 16, 2019

The White House has reversed its ruling from earlier this year that would have amended the safe harbor regulations eliminating traditional rebates and requiring discounts be moved to the point-of-sale. The ruling was designed to decrease the overall cost of drugs and lower the out-of-pocket cost bur...

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Trump Administration Withdraws Harmful Drug Rebate Safe Harbor Rule TRUMP ADMINISTRATION WITHDRAWS HARMFUL DRUG REBATE SAFE HARBOR RULE

article

Jul 15, 2019

On July 10, the Trump Administration announced that it would withdraw a proposed rule to eliminate the safe harbor in the federal anti-kickback law for rebates negotiated by pharmacy benefit managers (PBMs) on behalf of Medicaid managed care plans and Medicare Part D plans. This is a highly welcome ...

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New drug promises to end migraine pain in two hours NEW DRUG PROMISES TO END MIGRAINE PAIN IN TWO HOURS

article

Jul 11, 2019

There are patients who do not respond to the available migraine medications. The drugs also have other limiters: the possibility of strong side effects and the prohibition of prescription for individuals with cardiovascular disease, since they constrict the blood vessels. Researchers at the Albert E...

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PhRMA-backed Study Shows Hospitals Significantly Hike Drug Prices PHRMA-BACKED STUDY SHOWS HOSPITALS SIGNIFICANTLY HIKE DRUG PRICES

article

Jul 09, 2019

A study commissioned by Pharmaceutical Research and Manufacturers of America (PhRMA) revealed that hospitals across the United States typically charge five times more for medications than their costs. This results in an increase in cost-sharing and premiums for patients, the study found. The latest ...

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First Generic Launch has Significant First-Mover Advantage Over Later Generic Drug Entrants FIRST GENERIC LAUNCH HAS SIGNIFICANT FIRST-MOVER ADVANTAGE OVER LATER GENERIC DRUG ENTRANTS

article

Jul 08, 2019

The first generic drug to make it to market after drug patent expiration enjoys a significant market share advantage over later arrivals. Furthermore, market share advantage – which can be up to 90% – holds for at least three years.

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FOR AI-ENABLED DRUG DISCOVERIES, WHO OWNS THE SCIENCE? FOR AI-ENABLED DRUG DISCOVERIES, WHO OWNS THE SCIENCE?

article

Jul 08, 2019

Dealing with intellectual property issues presents a challenge, of sorts, for drug developers. The last in our series. There is no doubt that artificial intelligence is greatly influencing the field of drug discovery. For the past several days we’ve heard from a number of scientists, from the ...

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EU Approves Two-Drug Pill as First-Line Treatment for HIV EU APPROVES TWO-DRUG PILL AS FIRST-LINE TREATMENT FOR HIV

article

Jul 03, 2019

The two-drug pill Dovato, developed by the UK company ViiV Healthcare, has been approved as a first-line treatment for HIV, potentially causing fewer long-term side effects than current three-drug antiretroviral regimens. HIV patients currently need to take three or more antiretroviral drugs per day...

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FDA Gives Nod To 1st Sinusitis Drug That Includes Nasal Polyps FDA GIVES NOD TO 1ST SINUSITIS DRUG THAT INCLUDES NASAL POLYPS

article

Jul 03, 2019

In what specialists have termed to a pivotal point, the FDA approved a chronic sinusitis drug, a disease which causes polyps in the sinuses. Names Dupixent, the injection is administered every 2 weeks. Those with chronic rhinosinusitis and nasal polyps will be treated with this drug. FDA stated that...

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Gut Bacteria, Pitching In GUT BACTERIA, PITCHING IN

article

Jul 02, 2019

When a patient takes an oral dose of a drug, you can picture it as being a little like one of the those Japanese pachinko machines, where a ball drops into a maze of complicated bouncing paths on its way to the bottom. There are a lot of things that happen once a pill hits the gut, the broad feature...

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High Doses Of 60 Plus-Year-Old Chemo Drug Found To Spur Immune System Attack On Lymphoma HIGH DOSES OF 60 PLUS-YEAR-OLD CHEMO DRUG FOUND TO SPUR IMMUNE SYSTEM ATTACK ON LYMPHOMA

article

Jul 01, 2019

More than 60 years ago, British physician Denis Parsons Burkitt and his associates achieved one of the signal successes in cancer medicine when they cured children in sub-Saharan Africa with a form of lymphoma by treating them with high doses of the chemotherapy drug cyclophosphamide. Now, Dana-Farb...

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Is a diabetes drug the key to aggressive breast cancer? IS A DIABETES DRUG THE KEY TO AGGRESSIVE BREAST CANCER?

article

Jun 28, 2019

New research finds that the diabetes drug metformin changes stem cancer cells in a way that makes them easier to target with a new form of treatment. The findings could help treat triple-negative breast cancer, which is particularly aggressive.

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A Streamlined Pathway to Drug Approval A STREAMLINED PATHWAY TO DRUG APPROVAL

article

Jun 26, 2019

Randomized, placebo-controlled clinical trials have long been the gold standard for drug approval. Patients are assigned to either drug or placebo and the comparison between the two groups can provide meaningful data to allow the Food and Drug Association (FDA), pharmaceutical companies, physicians,...

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Insulin: why the price of a 100-year-old drug has tripled in a decade INSULIN: WHY THE PRICE OF A 100-YEAR-OLD DRUG HAS TRIPLED IN A DECADE

article

Jun 26, 2019

Insulin prices have skyrocketed to the point where many people with diabetes live in insulin poverty, with one in four rationing their insulin and an even larger proportion trading off other life necessities (food, rent, clothing) to afford their insulin supply. The rise in insulin prices has nothin...

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High Drug Prices Stoke Congress’ Ire HIGH DRUG PRICES STOKE CONGRESS’ IRE

article

Jun 25, 2019

Democrats and Republicans in Congress have found common ground when it comes to the issue of exorbitant prescription drug prices. Both agree some measure of market-based reform is needed to alleviate the burden on individual patients and on hospitals from rising drug prices, shortages of critical me...

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Urgent and labor-intensive: How inadequate drug shortage management tools impact hospital-system pharmacies URGENT AND LABOR-INTENSIVE: HOW INADEQUATE DRUG SHORTAGE MANAGEMENT TOOLS IMPACT HOSPITAL-SYSTEM PHARMACIES

article

Jun 24, 2019

Shortages of drugs have become a chronic condition in health-system pharmacies over the last five to seven years, and are a critical issue for both US1,2,3 and European4,5 health-system pharmacies. Excess costs for health systems are generated by higher costs of shorted medications and the extra lab...

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ASCO 2019: The future of Keytruda plus chemo combination therapy ASCO 2019: THE FUTURE OF KEYTRUDA PLUS CHEMO COMBINATION THERAPY

article

Jun 24, 2019

As the 40,000 attendees of this year’s ASCO conference relinquish their hold of the windy city, oncology experts worldwide begin contemplating the wealth of new or expanded data which was presented, and how it might affect their everyday practice. While ASCO 2019 was noticeably focused on prel...

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Drug testing helps secure safer workplace DRUG TESTING HELPS SECURE SAFER WORKPLACE

article

Jun 24, 2019

Employers committed to safety are continuing to follow best practices for maintaining a drug-free workplace, despite recent changes in employee drug testing laws. Surveys show drug abuse in the U.S. population has expanded in recent years, and it’s not something that impacts people only on the...

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6 Ways to Maximize Product Value as Loss of Exclusivity Approaches 6 WAYS TO MAXIMIZE PRODUCT VALUE AS LOSS OF EXCLUSIVITY APPROACHES

article

Jun 24, 2019

Loss of exclusivity does not mean the complete loss of an income stream as drug patent expiration approaches. Steps taken two years before loss of exclusivity can maximize brand value in the meantime. But the arrival of competitors means something different with pharmaceuticals than it does with oth...

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Can Drug Companies Bribe the FDA? CAN DRUG COMPANIES BRIBE THE FDA?

article

Jun 23, 2019

With drugs such as Lipitor achieving lifetime sales well over $100 billion, the motivation to use any means available to ensure drug approval is clear. Bribery of FDA officials has occurred in the past, but is unlikely to occur again for the reasons described below. The overall objective of the drug...

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Maryland Creates Prescription Drug Affordability Board for Setting Price Caps MARYLAND CREATES PRESCRIPTION DRUG AFFORDABILITY BOARD FOR SETTING PRICE CAPS

article

Jun 22, 2019

As we have previously reported, the federal government has taken an acute interest in pharmaceutical drug pricing, resulting in a raft of hearings and draft legislation. States are getting on board too, with a Maryland law to go into effect on July 1, 2019, creating a Prescription Drug Affordability...

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No Surprise – Drug Pricing Legislation Picking up Steam NO SURPRISE – DRUG PRICING LEGISLATION PICKING UP STEAM

article

Jun 20, 2019

Legislation that addresses the cost of prescription drugs is inching closer to moving out of Congress. On Yesterday, the Senate Health, Education, Labor and Pensions (HELP) Committee held a hearing on the bipartisan Lower Health Care Costs Act (LHCCA) discussion draft. Today, the Committee released ...

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Top Drug Companies, Corporation Reputations and Marketing Budgets TOP DRUG COMPANIES, CORPORATION REPUTATIONS AND MARKETING BUDGETS

article

Jun 20, 2019

The public’s perception of the drug industry can be confusing. For example, a poll conducted by the Kaiser Family Foundation (KFF) on public opinion on prescription drugs and their prices between 2015 and 2018, found that 80% of the public said the cost of prescription drugs was unreasonable. ...

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Drug Boosts Growth In Youngsters With Most Common Form Of Dwarfism DRUG BOOSTS GROWTH IN YOUNGSTERS WITH MOST COMMON FORM OF DWARFISM

article

Jun 19, 2019

A ground breaking drug that helps regulate bone development has boosted growth rates in children with achondroplasia – the most common type of dwarfism – in a global trial led by Melbourne’s Murdoch Children’s Research Institute. Results of the Phase 2 trial in children aged ...

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Immunotherapy Drug Shows Potential To Cure Advanced Lung Cancer IMMUNOTHERAPY DRUG SHOWS POTENTIAL TO CURE ADVANCED LUNG CANCER

article

Jun 18, 2019

In a new study including Yale Cancer Center and Smilow Cancer Hospital researchers, the cancer immunotherapy drug pembrolizumab (Keytruda), increased survival for patients with advanced non-small cell lung cancer (NSCLC), a disease once considered an aggressive, and uniformly fatal cancer. The findi...

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Athletes and Drug Abuse: A Disturbing Trend in Modern Sports ATHLETES AND DRUG ABUSE: A DISTURBING TREND IN MODERN SPORTS

article

Jun 15, 2019

Drug abuse is a common occurrence across all types of sports, at all competitive levels. Besides just performance-enhancing drugs such as steroids and stimulants, many athletes feel compelled to abuse drugs and alcohol for a variety of other reasons. The intense pressure to perform, coupled with a p...

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Generic Drug Market Entry in Europe: Why a Tailored Approach Is Best GENERIC DRUG MARKET ENTRY IN EUROPE: WHY A TAILORED APPROACH IS BEST

article

Jun 10, 2019

Many government and healthcare authorities across Europe are concerned about rising pharmaceutical prices, and they increasingly promote the use of generics over branded drugs when possible. This is good news for companies interested in generic drug market entry in Europe.

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New tentative approval for Watson Labs drug dienogest; estradiol valerate NEW TENTATIVE APPROVAL FOR WATSON LABS DRUG DIENOGEST; ESTRADIOL VALERATE

article

Jun 09, 2019

This ingredient has seventy-three patent family members in thirty-eight countries. Two suppliers are listed for this compound. There is one tentative approval for this compound.

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JAMA Reports Higher U.S. Brand Drug Prices JAMA REPORTS HIGHER U.S. BRAND DRUG PRICES

article

Jun 06, 2019

I’ve recently been exercising bragging rights about our new and improved drug price comparisons. Americans seeking medicine from Canada and other countries are finding better deals on generics right here at home. But the crisis of high drug prices in the U.S. persists when it comes to brand me...

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‘Bottle of Lies’ Author Katherine Eban: Dispense as Written ‘BOTTLE OF LIES’ AUTHOR KATHERINE EBAN: DISPENSE AS WRITTEN

article

May 31, 2019

“Dispense as Written” are the words found on prescriptions in the U.S. when the prescriber wants the patient to take the brand drug, not the generic. Many who read Katherine Eban’s new book – Bottle of Lies: The Inside Story of the Generic Drug Boom – will conclude that...

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The Opioid Crisis in America Course from Harvard University THE OPIOID CRISIS IN AMERICA COURSE FROM HARVARD UNIVERSITY

article

May 17, 2019

Over 700,000 people died in the U.S. from a drug overdose between 1999 to 2017. That’s about 130 American deaths daily. At PharmacyChecker, we are dedicated to helping fight this epidemic by learning more about the crisis and spreading awareness. I recently obtained certification for The Opioi...

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NABP-Accredited Rochester Drug Cooperative Pleads Guilty to Illegal Opioid Drug Sales NABP-ACCREDITED ROCHESTER DRUG COOPERATIVE PLEADS GUILTY TO ILLEGAL OPIOID DRUG SALES

article

May 10, 2019

Rochester Drug Cooperative, a large pharmacy wholesaler accredited by the National Association of Boards of Pharmacy (NABP), pleaded guilty last week to illegal sales of opioid drugs, including oxycodone and fentanyl. The NABP operates a program called Verified Authorized Wholesale Distribution (VAW...

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Drug-Patent Rules, Alleged Abuses Under Senate Panel’s Scrutiny DRUG-PATENT RULES, ALLEGED ABUSES UNDER SENATE PANEL’S SCRUTINY

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May 07, 2019

Federal patent rules and the debate over whether they make prescription drugs more expensive are set to take center stage at a Senate hearing today. Sen. John Cornyn (R-Texas) is leading a push to see if pharmaceutical companies are abusing federal laws to extend the life of their patents and fend o...

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Pill Presses and Counterfeit Prescription Narcotics: Supporting the STEER Act PILL PRESSES AND COUNTERFEIT PRESCRIPTION NARCOTICS: SUPPORTING THE STEER ACT

article

May 03, 2019

In their opposition to drug importation legislation, the myriad “non-profit” groups funded by drug companies often cynically invoke the evils of counterfeit drugs. We’ve seen this as recently as this week, when an importation bill triumphantly passed in Florida (Prescription Drug I...

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Can a blood pressure drug protect the brain from Parkinson CAN A BLOOD PRESSURE DRUG PROTECT THE BRAIN FROM PARKINSON'S?

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Apr 23, 2019

A prescription drug already in use for the treatment of high blood pressure could be effective against conditions such as Parkinson's, Alzheimer's, and Huntington's, in which toxic proteins build up in brain cells. Scientists at the University of Cambridge in the United Kingdom and the G...

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Rite Aid To Stop e-Cigarette Sales In Its Stores, Sell CBD Products In Two States RITE AID TO STOP E-CIGARETTE SALES IN ITS STORES, SELL CBD PRODUCTS IN TWO STATES

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Apr 16, 2019

With a crackdown on the e-cigarettes, Rite Aid is now going to sell CBD products comprising of creams, lip balms and lotion in its 200 stores spread across states of Oregon and Washington this month. This step has been taken after the interests of the customers in the purchase of CBD products as say...

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Florida’s House Drug Importation Bill – HB 19 – Easily Passes FLORIDA’S HOUSE DRUG IMPORTATION BILL – HB 19 – EASILY PASSES

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Apr 12, 2019

If HB 19 becomes law, the Florida Agency for Health Care Administration (AHCA) will create processes that meet the safety protocols called for in the bill, which include inspections and testing of drugs, to allow registered wholesale pharmacies to import from Florida-registered Canadian wholesalers....

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Immuron To Pursue Clinical Development Through FDA For IMM-124E As TD Drug IMMURON TO PURSUE CLINICAL DEVELOPMENT THROUGH FDA FOR IMM-124E AS TD DRUG

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Apr 11, 2019

Immuron Limited (ASX: IMC) is a biopharmaceutical sector company with operations in Australia. The group is also engaged in the commercialization and development of oral immunoglobulin therapeutics for the treatment of gut mediated diseases. The company today, on 11th April 2019, announced plans to ...

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Five Reasons to Embrace Data-Driven Drug Development FIVE REASONS TO EMBRACE DATA-DRIVEN DRUG DEVELOPMENT

article

Mar 08, 2019

The growth of the pharmaceutical and biotechnology industry depends on successful clinical trials. The cost of developing a new drug that gets approval is estimated at around $2-3 billion. The longer the trial lasts and the more patients it has involved, the larger the loss. The researchers at Johns...

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Researcher uses HPV vaccine to treat patients with skin cancer RESEARCHER USES HPV VACCINE TO TREAT PATIENTS WITH SKIN CANCER

article

Jul 03, 2018

Squamous cell carcinoma is the second-most-common form of skin cancer. Evidence suggests the human papilloma virus plays a role in the development of some types of this skin cancer. Two years ago, a 97-year-old woman whose right leg was covered with squamous cell tumors went to see dermatologist Ann...

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New Regulations And Safety Complicate Drug Labeling NEW REGULATIONS AND SAFETY COMPLICATE DRUG LABELING

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Jul 02, 2018

Multinational pharmaceutical companies have for decades manufactured drugs for global distribution. Nevertheless, the task of labeling is becoming increasingly difficult and time-consuming. With new labeling requirements that can vary by country and region, drug companies are forced to either develo...

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Use of State Medicaid Inflation Rebates Could Discourage Drug Price Increases USE OF STATE MEDICAID INFLATION REBATES COULD DISCOURAGE DRUG PRICE INCREASES

article

Jun 28, 2018

List prices for prescription drugs set by the manufacturer before discounts and rebates have grown faster than the rate of inflation.1 In 2015, average drug list prices increased by 6.4 percent, while general inflation only increased by 0.1 percent. 2 Although price concessions, primarily in the for...

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New Study Shows Drug War Sends Users to Dark Web NEW STUDY SHOWS DRUG WAR SENDS USERS TO DARK WEB

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Jun 19, 2018

A new study published in the British journal BMJ says restricting the supply of illegal drugs forces users into black markets, where the drugs get more dangerous and more addictive. The authors of the study looked at the effect of the DEA's rescheduling of hydrocodone in 2014 from a schedule III...

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How Correctional Facilities Could Lower Drug Prices HOW CORRECTIONAL FACILITIES COULD LOWER DRUG PRICES

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Jun 14, 2018

State and local correctional facilities, including prisons and jails, are required to provide health care to incarcerated adults.1 Drug spending has an outsize impact on correctional health care budgets: Of the states that report drug spending, the majority spend more than 15 percent of their health...

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Nigeria’s drug makers upgrade factories to push for more WHO certifications NIGERIA’S DRUG MAKERS UPGRADE FACTORIES TO PUSH FOR MORE WHO CERTIFICATIONS

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Jun 05, 2018

The quest to obtain the World Health Organisation (WHO)’s prequalification is pushing more local pharmaceutical companies into upgrading their machinery and factories, with a number of them investing in new facilities. The WHO prequalification enables a pharmaceutical company to participate in...

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Study finds rare gain for tough-to-treat pancreatic cancer STUDY FINDS RARE GAIN FOR TOUGH-TO-TREAT PANCREATIC CANCER

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Jun 04, 2018

Patients with pancreatic cancer that hadn’t spread lived substantially longer on a four-drug combo than on a single standard cancer drug, a rare advance for a tough-to-treat disease, researchers reported Monday. The results indicate the powerful chemotherapy treatment known as folfirinox will ...

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Trump Drug Pricing Plan Outlines Rule Changes Pharma Can Live With TRUMP DRUG PRICING PLAN OUTLINES RULE CHANGES PHARMA CAN LIVE WITH

article

May 14, 2018

After months of expectations and repeated delays, President Donald Trump formally announced his strategy for making prescription medicines more affordable and accessible in the U.S. Trump promised to take on the “tangled web of special interests” that drive up drug prices, noting the hig...

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Jeff Sessions decision to re-up in the drug war won JEFF SESSIONS DECISION TO RE-UP IN THE DRUG WAR WON'T WORK

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May 14, 2018

Attorney General Jeff Sessions’ newly issued sentencing directive to federal prosecutors, revoking the Obama-era Smart on Crime Initiative, is a devastating revival of the War on Drugs. The repercussions of this move will undoubtedly reverse the decline in the federal prison population of rece...

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Trump Speaks About Proposal to Lower U.S. Drug Prices TRUMP SPEAKS ABOUT PROPOSAL TO LOWER U.S. DRUG PRICES

article

May 11, 2018

President Donald Trump is expected to unveil a proposal today to bring down U.S. drug prices. The blueprint, called American Patients First, is meant to increase pharmaceutical competition and lower patients’ out-of-pocket costs. Trump is scheduled to speak about the plan's details at 2 p....

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President set to outline drug pricing plan: how far will it go? PRESIDENT SET TO OUTLINE DRUG PRICING PLAN: HOW FAR WILL IT GO?

article

May 10, 2018

Tomorrow at 2 p.m., EST, the President is scheduled to deliver a long-awaited drug pricing strategy speech to put “America’s patients first.” While details of the speech have been closely held, it is anticipated that it will discuss a “comprehensive strategy” for combat...

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Drug Take Back Day Sets State Record DRUG TAKE BACK DAY SETS STATE RECORD

article

May 04, 2018

The Manchester Police Department collected 33 pounds of medication for disposal at the Drug Take Back Day Saturday at Brehme Drug. Residents of the state disposed of 12,333 pounds of old or unused prescription drugs during Saturday’s event. According to the Governor’s Office of Drug Cont...

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How synthetic opioids can radically change global illegal drug markets and foreign policy HOW SYNTHETIC OPIOIDS CAN RADICALLY CHANGE GLOBAL ILLEGAL DRUG MARKETS AND FOREIGN POLICY

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Apr 30, 2018

Replacing drugs derived from plants (e.g., heroin, cannabis) with synthetic analogues (e.g., fentanyl, spice/K2) could be the most disruptive innovation in the history of the international drug trade. As we explain in the current issue of Foreign Affairs, it may also alter international relations an...

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Amazon vs. Walmart: Can Corporate America Lower Drug Prices? AMAZON VS. WALMART: CAN CORPORATE AMERICA LOWER DRUG PRICES?

article

Apr 10, 2018

The former statement comes as no surprise. Americans spend $450 billion on medications annually, a figure projected to reach as much as $610 billion by 2021.(www.cnbc.com) Every family physician knows patients who have cut their meds in half, skipped doses or simply forgone medications because they ...

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Treating Hearing Loss: A Set of Inhibiting Drugs Provide Promising Results TREATING HEARING LOSS: A SET OF INHIBITING DRUGS PROVIDE PROMISING RESULTS

article

Mar 12, 2018

Our inner ears contain roughly 30,000 tiny hair cells that work to detect sound waves as well as to translate these waves into nerve signals. The nerve signals allow us to hear everyday sounds from speeches to music. However, any damage to the hair cells leads to hearing loss, a condition that affec...

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Yet More Good News for GW Pharma’s Cannabinoid Drug Against Epilepsy YET MORE GOOD NEWS FOR GW PHARMA’S CANNABINOID DRUG AGAINST EPILEPSY

article

Jan 25, 2018

GW Pharmaceuticals has achieved encouraging Phase III results for Epidiolex, which have been published in leading scientific journal, The Lancet. The company’s lead candidate is being developed for the treatment of epilepsy – a condition characterized by the abnormal firing of neurons in...

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Drug Synthesis In Printed Reactors DRUG SYNTHESIS IN PRINTED REACTORS

article

Jan 23, 2018

I’m still trying to get my bearings with this new paper from the Cronin group at Glasgow. What it proposes is a new style of API (active pharmaceutical ingredient) production. Instead of being done in bench- or process-scale lab glassware or in production-plant reactors, these syntheses take p...

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Drug Pricing Dominates Senate Hearing on HHS Nominee Azar DRUG PRICING DOMINATES SENATE HEARING ON HHS NOMINEE AZAR

article

Jan 10, 2018

If confirmed as the next secretary of the Department of Health and Human Services (HHS), Alex Azar says that a top priority is to make drugs more affordable. He agreed with members of the Senate Finance Committee at his confirmation hearing January 9 that “drug prices are too high,” but ...

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Cancer Drug Raises Risk of Cardiovascular Toxicity CANCER DRUG RAISES RISK OF CARDIOVASCULAR TOXICITY

article

Jan 01, 2018

A drug approved by the FDA in 2012 to treat a type of cancer called multiple myeloma has dangerous side effects that involve the heart. The drug is called carfilzomib, and it is a proteasome inhibitor now linked to an increased risk of dangerous heart events. High blood pressure, heart failure, hear...

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Design, formulation and manufacture of film-coated drug products DESIGN, FORMULATION AND MANUFACTURE OF FILM-COATED DRUG PRODUCTS

article

Oct 25, 2017

Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation strategy and to modify or delay drug release.

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Shining the light on drug-drug interactions (DDI) SHINING THE LIGHT ON DRUG-DRUG INTERACTIONS (DDI)

article

Oct 04, 2017

Advancements in vitro technologies and analytical instrumentation over the past decade allow scientists to apply a variety of in vitro based assays designed to rapidly assess risk-liability, such as drug-drug interactions (DDI), one of the factors contributing to both current high attrition rates an...

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The Growing Role of Polymer Synthesis Driven by Modern Advances in Drug Delivery THE GROWING ROLE OF POLYMER SYNTHESIS DRIVEN BY MODERN ADVANCES IN DRUG DELIVERY

article

Aug 07, 2017

Not everyone knows what Polymer Synthesis is, but many have heard of new innovations in how drugs are delivered and absorbed into the body. Thanks to polymer synthesis, implantable devices are administering consistent medications into patients who sorely need them; those with pacemakers are being sp...

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Revolutionizing Drug Development—d3 Medicine Joins the Certara Family REVOLUTIONIZING DRUG DEVELOPMENT—D3 MEDICINE JOINS THE CERTARA FAMILY

article

Nov 11, 2016

The d3 Medicine staff join Certara’s Strategic Consulting (CSC) division, which was formed in July 2015 through the merger of Quantitative Solutions and Pharsight Consulting Services. We are now the largest and most transformational consultancy of its kind, with more than 100 scientists, most ...

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Drug makers kept many clinical trial results a secret: study DRUG MAKERS KEPT MANY CLINICAL TRIAL RESULTS A SECRET: STUDY

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When it comes to disclosing clinical trial data, some drug makers are still keeping secrets, according to a new study. Thirty-five percent of all trial results for 15 drugs that were approved in 2012 by the Food and Drug Administration were not publicly disclosed. And nearly 30 percent of the trials...

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Drug makers beat diabetes lawsuits with an unusual ruling DRUG MAKERS BEAT DIABETES LAWSUITS WITH AN UNUSUAL RULING

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Several drug makers were handed an unexpected victory this week when a federal judge ruled they weren’t required to update product labels to warn about risks of pancreatic cancer with their diabetes medicines. In a 35-page ruling, US District Court Judge Anthony Battaglia explained the labelin...

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SPOTLIGHT

Mr. Manne Venkanna Chowdary, CMD, AmpleLogic speaks to the audience at IDMA's 21st Pharmaceutical Analysts' Convention – ‘Technology – The Game Changer’ in Mumbai (24th and 25th May 2019) on the topic ‘Digitalization in Pharma with Intelligent Systems, Collabora

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