RESOURCES

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Read the Deck 7 Webinar Benchmarks & Best Practices Report to see how your webinars measure against market benchmarks. And learn about the best practices

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Apr 16, 2020

Over the past two years, the pharmacy industry has seen unprecedented increases in the prices of generic drugs, causing unexpected cost increases for payers and consumers, and spurring an investigation by the United States Congress. High generic drug prices have had an adverse effect on almost every...

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Apr 08, 2020

EPHA is a change agent – Europe’s leading NGO alliance advocating for better health. We are a dynamic member-led organisation, made up of public health civil society, patient groups, health professionals, and disease groups working together to improve health and strengthen the voice of p...

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Apr 07, 2020

The information in this document is designed to help you understand the prescription drug benefits offered under this plan and to compare these benefits to those offered by other plans. Information contained in this summary is designed to help you compare both the value and scope offormulary benefit...

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Mar 16, 2020

With the rapid onset of coronavirus in the United States, many pharma companies are being forced to prepare for a scenario in which their reps cannot visit providers and patients are limited in their ability to visit their healthcare professionals (HCP). The CDC has gone as far as recommending the u...

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Jan 12, 2020

Supply chains grow more and more complex every day. In response, manufacturers and shippers have been eagerly exploring digital tools that provide actionable insight into the location and condition of in-transit goods. Although there are many technology options when it comes to building a digital su...

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Jan 01, 2020

Life sciences is facing a number of disruptors: novel cell and gene therapies that will revolutionize manufacturing, drug delivery and pricing models; a battle for the best and brightest talent; political and public pressure on the price of medication as well as the implications of the fourth indust...

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Dec 19, 2019

Welcome to European Pharmaceutical Review’s Application Notes & Whitepapers Supplement 2019. This year’s topics range from analytical techniques for bioprocess investigation, host cell protein analysis and Raman imaging to advice on outsourcing services for product characterisation.

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Dec 16, 2019

The use of FAIR (Findable, Accessible, Interoperable and Reusable) data in drug discovery and development could be transformational. But the pharma industry has been slow to embrace FAIR data — partially because of difficulties in establishing the necessary infrastructure and because of intern...

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Dec 12, 2019

X-ray inspection of pharmaceutical products and over-the-counter (OTC) medications are steadily increasing in use as pharmaceutical manufacturers worldwide strive to safeguard their brand reputations, protect consumers' welfare and comply with national and international regulations and legislati...

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Nov 25, 2019

It's clear that healthcare prices weigh heavily on the minds of Americans, and the time has come for the pharmaceutical industry to take the reins of the prescription drug pricing dialogue with consumers.

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Nov 07, 2019

This in-depth paper will show you how to become data agile – tackling both technological issues and solutions, and the cultural and strategic framework needed around this to ensure success.

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Oct 31, 2019

Clinical trial data come from many different clinical (i.e. EDC, eCOA, lab, ePro, EMR/EHR, biomarker, mHealth / IoT), and operational (project management, eTMF, regulatory, financial, employee) sources and formats.

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Oct 31, 2019

This study has demonstrated that, even though there is oxidation in materials such as copper or POM, the most common materials found in the pharmaceutical industry are not affected by a low concentrated solution.

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Oct 29, 2019

It is important to control the level of endotoxin units in materials used in the production of drug products and medical devices, especially those that cannot undergo depyrogenation.

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Oct 29, 2019

Without the right design, right data and right decisions, idealised clinical trial plans cannot be translated into blueprints for robust studies.

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Oct 25, 2019

Discover the latest tech and systems that have changed the game in pharmaceutical manufacturing

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Oct 09, 2019

Quality control (QC) plays a major role in the development of safe, highquality pharmaceutical products. This Pharmaceutical Technology/ Spectroscopy eBook on Pharma Quality Control Testing helps laboratories ensure they are up to date on the latest tools and techniques for achieving precise and eff...

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Oct 04, 2019

This whitepaper explores both of these two principle approaches and is broadly broken-down into two areas.

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Oct 01, 2019

The diversity of products that contain cannabis means that a “one-size-fits-all” regulatory framework would be ineffective.

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Sep 30, 2019

The DTx market is like the early days of the biologics revolution. “We are right at the beginning – it is a whole new therapeutic modality and we have the opportunity to create upwards of 100 products to increase efficacy across a range of disease conditions”. But does it represent...

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Sep 27, 2019

How your staff can be relieved from drudgery, augment their capacity, and unleash creativity with Robotic Process Automation (RPA) in life sciences

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Sep 18, 2019

The characterization of novel therapeutics involves many chemical processes. A typical workflow of methods that are frequently carried out during drug discovery is depicted below.

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Sep 13, 2019

The pharmaceutical R&D ecosystem relies on effective collaboration between internal and external stakeholders to collect, analyze, and share data in a secure, compliant, and efficient manner.

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Sep 10, 2019

Modern drug discovery is a complicated process that requires identification of disease targets, bioactive substances that act upon those targets, and finally optimization of those drug candidates.

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Sep 03, 2019

Facilities flexible enough to manufacture multiple products have become a cornerstone of our industry, crucial for meeting changing and challenging market and regulatory expectations.

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Aug 31, 2019

Delivery of therapeutics to the human eye is one of the most interesting endeavors a formulator can take on, but also one of the most challenging.

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Aug 29, 2019

Injuries which occur on regular basis in day today routine of hospital and healthcare setups. The Plethora of new injectable products has created new opportunities for physicians to treat areas previously thought to be not reachable.

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Aug 29, 2019

In account-based marketing (ABM) campaigns, B2B marketers can target contacts with pinpoint accuracy through programmatic advertising. They can also create personalized content for buyers at every stage of the purchase journey. However, three challenges remain: Are businesses targeting the right con...

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Aug 25, 2019

Medication shortages come with a substantial cost to pharmaceutical companies—loss of revenue, provider loyalty, and brand reputation pose significant and detrimental threats to business. Currently, the United States Food and Drug Administration (U.S. FDA) lists over 150 drug shortages, costin...

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Aug 21, 2019

In practice, of course, things are more complicated. Effective translation necessitates a nuanced understanding of (at least) two languages and cultures, both source and target. It requires an understanding of the original content’s goals. It mandates a fluency in tone and subtext as well as v...

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Aug 21, 2019

Your localization partner is going to do a deep-dive into your business—so start by diving deep into theirs. Are they an industry-leader with 20 years of experience or a relative newcomer? Will they speak Samoan, Uzbek, or Swahili (and all your customers’ languages)? Can they deliver on-...

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Aug 19, 2019

Benzer Pharmacy Specialty Pharmacy Patient Management Program proactively works with patients in a number of chronic disease states to provide specialty pharmaceuticals and therapy management support services to obtain optimal therapeutic outcomes thus avoiding adverse drug events and unnecessary co...

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Aug 19, 2019

This white paper highlights the language challenges found in a global clinical trial and offers a number of best practices for managing the translation effort. Failure to adequately plan for translation introduces several new risk factors that must be considered in today’s highly-competitive p...

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Aug 14, 2019

Content—and how brands use it to interact with buyers at all stages of the engagement journey—has fundamentally reshaped every business’ go-to-market strategy. This shift has been particularly challenging for “top-of-the-funnel” demand generation marketers, most of who ...

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Aug 02, 2019

Dynamics between pharma and the market-based healthcare sector it serves have invariably been complex, with one of the biggest drivers of that complexity being effective management of patient demand and payer systems.

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Jul 25, 2019

Drug-nutrient interactions (DNIs) are defined as physical, chemical, physiologic or pathophysiologic relationships between a drug and a nutrient present in a food or a supplement.3

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Jul 23, 2019

When it comes to safely and securely transporting high value pharmaceutical products, the stakes couldn’t be higher. Not only is a single consignment of high value drugs potentially worth upwards of $50 million, but, for those patients in need of these drugs, ensuring these products arrive on ...

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Jul 22, 2019

Forbes predicts that AI in healthcare will top US$1.7 billion by the end of the year. Download our free whitepaper today and learn the top 5 ways artificial intelligence is driving exciting change that will improve patient outcomes.

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Jul 19, 2019

With the end of the Medical Device Regulation’s (MDR) transition period looming (May 26th, 2020), manufacturers of drug device combination products or companion diagnostics are under heightened time pressure to comply with the new Regulation. Any company manufacturing or distributing these pro...

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Jul 17, 2019

IoT technologies are proving to be of great benefit to pharmaceutical organizations that aim to innovate. The ability to integrate informatics solutions in pharmaceutical environments enables organizations to streamline and standardize connectivity from previously disparate equipment, networks, and ...

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Jul 17, 2019

The development of a pharmacovigilance and risk management system to support a gene therapy for a rare genetic disease requires consideration of the specific challenges and nuances that novel therapies present throughout the lifetime of the product.

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Jul 15, 2019

If you’re on a B2B revenue team, it’s likely your Marketing and Sales teams are experiencing some angst these days when it comes to understanding how prospects and customers want to interact with your company. On one hand customers seem to want ultra-personalized attention on every chann...

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Jul 15, 2019

Our latest white paper discusses the dynamics and marketing of 2018’s top selling drugs, chief therapeutic areas, and biosimilar erosion, with a deeper dive into the top three drugs: Humira, Revlimid, and Opdivo.

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Jul 12, 2019

From our understanding today, there are many environmental chemicals that carry the potential to affect the endocrine system. Known as endocrine disrupting chemicals (EDCs), these compounds alter drug and xenobiotic metabolic processes and can interfere with the production, release, metabolism, and ...

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Jul 11, 2019

This eBook takes readers through an example of discourse analysis of a patient community on Inspire. In the process, author Kathryn Ticknor demonstrates how the language of patients is a different language from “medicalese,” the language of medicine. Her insights are a first step in lear...

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Jul 10, 2019

Oxetanes have been employed to improve drugs’ physiochemical properties. Currently, over a dozen oxetane-containing drugs have progressed to different phases of clinical trials. Once one of them gains the FDA approval, the enthusiasm toward its utility in drug discovery will grow exponentially...

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Jul 10, 2019

Pharmaceutical companies face the challenge of reducing production costs without negatively affecting the quality of the finished products. HVAC systems are one of the main energy consumers in pharma facilities especially in sterile manufacturing. Therefore energy savings are particularly noticeable...

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Jul 10, 2019

Pharmaceutical operations are inherently complex, and the bar seems to get higher with each passing year and with the issuing of new guidance. Staying current is not easy and managing the inherent, ever-growing complexity can be a serious challenge.

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Jul 10, 2019

Counterfeit products naturally pose a major problem in the pharmaceutical sector. This affects brand-name and generic products as well as OTC (over the counter) products. Counterfeiters not only bring imitation medication into circulation through non-authorized pharmacies and online portals, but als...

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Jul 10, 2019

The rising cost of pharmacovigilance (PV) tasks has been an ongoing challenge for the pharma industry. Many companies have chosen to shift these tasks to overseas vendors to take advantage of cheaper labor without compromising quality.

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Jul 09, 2019

Artificial intelligence (AI) is crucial for discovering, exploring, and understanding this textual information and a critical tool for developing new drugs, designing clinical trials, receiving drug approvals and more.

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Jul 08, 2019

Our latest white paper discusses the dynamics and marketing of 2018’s top selling drugs, chief therapeutic areas, and biosimilar erosion, with a deeper dive into the top three drugs: Humira, Revlimid, and Opdivo.

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Jul 08, 2019

Decisionmaking is a cognitive process defined by psychologists as the selection of a course of action from multiple alternatives (e.g. what to eat, where to shop). John Dewey, the pragmatic philosopher and psychologist, introduced the first decision process framework for consumer buying in his book ...

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Jun 29, 2019

The cannabis business is booming and pharma is looking to get in on the action with new business models and potential new drugs derived from the cannabis plant.

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Jun 26, 2019

A pharma lab needs regulatory documentation, while a diagnostics lab requires advanced tracking of biospecimens. Traditionally, each would begin with the same basic building blocks: a Laboratory Information Management System (LIMS) with standalone point solutions such as an Electronic Laboratory Not...

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Jun 26, 2019

The term blockchain is most often associated with cryptocurrencies such as Bitcoin, but the technology and its implications could have a more far-reaching impact on other industries including pharmaceutical manufacturing. Contract drug manufacturing organizations (CDMOs) and pharmaceutical developer...

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Jun 25, 2019

The average cost of bringing a new drug to market continues to rise, with varying levels of investments across the highly competitive biopharmaceutical industry. To assess the potential effect of varying investments on trial activity and operations, this article reviews trial benchmarks within the a...

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Jun 25, 2019

This application demonstrates the 2D-LC/MS/MS analysis of cell supernatants from an in vitro cell suspension-based assay. Superior separation by 2D-LC allowed the analysis of 16 target metabolites within 35 minutes.

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Jun 25, 2019

Gaps in dermatological research present potentially lucrative market opportunities for pharmaceutical companies. Patients that suffer from skin conditions and diseases also benefit. Effective treatments relieve irritating, chronic, and often painful symptoms, which improves their quality of life and...

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Jun 24, 2019

We believe that data-driven marketing shouldn’t be confusing. Every company should know what works for their campaigns in order to make more ROI-driven decisions. At Directive, we not only craft customized campaigns for your unique marketing objectives - we exceed those objectives and truly re...

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Jun 24, 2019

Today’s surge of big data coming from multiple sources is raising the stakes that pharmacovigilance has to win, making evidence synthesis a more and more robust approach in the field. In this scenario, many scholars believe that new computational methods derived from data mining will effective...

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Jun 24, 2019

Pharmaceutical companies face a ‘digital imperative’ to engage with healthcare professionals through their preferred mix of channels if they are to bridge the gap between the value a company can offer and an HCP’s needs.

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Jun 19, 2019

This paper, authored by Alireza Shabani, Founder & CEO of Qulab, describes the necessary computational architecture for pharmaceutical firms to accelerate R&D and drug discovery, especially utilizing special purpose silicon and quantum processors.

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Jun 19, 2019

This white paper fully explains the requirements of the 2019 versions of the USP General Chapters 41 and 1251 and provides guidance on how to put these requirements into practice. Weighing according to USP requirements ensures that consistently high quality weighing results are achieved and applies ...

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Jun 19, 2019

USP Chapter 41 weighing requirements are mandatory in a Pharmaceutical Quality Control (QC) laboratory, where weighing is a fundamental step in almost every workflow. Typically, weighing of a sample or standard is the first step in the analytical procedure, followed by subsequent dilution and analys...

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Jun 11, 2019

Vaccines have historically been a challenging corner of the industry, as they are highly-regulated and require a greater investment of time and money to develop than other biologics.

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Jun 11, 2019

Take the analysis from the Informa Pharma Intelligence R&D Annual Review 2019 further with the Pharma R&D Annual Review 2019 Supplement: New Active Substances Launched During 2018. This essential whitepaper uses critical data from Pharmaprojects to examine the new entities that were successf...

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Jun 11, 2019

Contract development and manufacturing organisations (CDMOs) in the pharmaceutical world are on the up. They benefit from an increasing number of companies that outsource parts of their production to external service providers.

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Jun 11, 2019

The cost of employee substance abuse adds up quickly, and it is vital for your company to detect and deter drug and alcohol abuse among employees.

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Jun 09, 2019

This thought piece explores the concept of agile working for the pharma world, delving into the opportunities and challenges that arise for CI teams and managers as working environments adapt to find success in a more dynamic, uncertain, and fast-paced environment.

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Jun 06, 2019

Sartorius Cubis® II is designed to follow US FDA data integrity principles that require data to be accurate, legible, contemporaneous, original and attributable.

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Jun 03, 2019

This white paper looks at the potential of x-ray inspection to solve a wide range of product safety and quality control issues typically found within food and pharmaceutical manufacturing. It explores how x-ray inspection can detect faulty products before they leave the factory, avoiding product rec...

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May 30, 2019

Pharmaceutical manufacturing is an industry laden with many challenges and risks due to the life-changing nature of its products—drugs that can affect millions of human lives. Manufacturers perform immensely complex research and testing daily, while facing economic challenges and regulatory re...

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May 30, 2019

It is common to find Intermediate Bulk Containers (IBCs) being used for handling powders and granules in solid dosage manufacturing processes, from initial Dispensing through to Tablet Compression or Capsule Filling. The benefits of using IBCs for efficient and flexible materials handling at this st...

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May 29, 2019

The buzz may be around biologics, but the oral solid dose sector is still going strong

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May 28, 2019

Embracing and investing in new technologies is one way to get ahead, and adopting lean, efficient manufacturing procedures is another. At a fundamental level, achieving efficiency can start at the outset of a project by considering the very design of a production facility. Careful planning can cut c...

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May 27, 2019

The biopharma sector has seen incredible growth in recent decades, with growth the major long-term trend. Total annual revenue has increased from about $4.4 billion in 1990 to now about $275 billion, an increase of 6,250 percent, with biopharmaceuticals now more than 25 percent of the total pharmace...

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May 27, 2019

Pharmaceutical manufacturing is not immune to metal-object contamination, it is important to discuss ways to effectively incorporate metal detection into the production or packaging processes when practicable.

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May 22, 2019

Rapid and consistent in-vivo drug dissolution is critical for drug absorption. In-vitro dissolutions tests are used to predict in-vivo disintegration and dissolution properties of drug products. The invitro disintegration and dissolution times of tablets and capsules can vary significantly based on ...

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May 13, 2019

Assume a generic drug company, let’s call them AB Generics, Inc., always targets the introduction of its generic drugs when the reference product comes off patent.

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May 13, 2019

Vaccines and vaccination efforts have effectively prevented many life-threatening or debilitating infectious diseases and are regarded as one of the greatest achievements in the field of public health.

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May 06, 2019

The growth of injectable critical care therapeutics requires multi-layer protection and authentication solutions.

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May 01, 2019

The past year was marked by shifting business models, more stringent quality requirements, technological improvements and mounting political pressures to solve pharma-related policy issues. How has the industry responded?

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Apr 30, 2019

Demand forecasting plays a critical role in logistics and supply chain management. In the paper, state-of-art methods and key challenges in demand forecasting for the pharmaceutical industry are discussed. An integrated procedure for in-market product demand forecasting and purchase order generation...

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Apr 30, 2019

Sharp rises in opioid abuse and overdose rates in the United States over the past two decades have prompted much-needed review of prescription rates and ease of access to controlled substances. Combatting these alarming trends requires assessing which opioids are more addictive and habit-forming tha...

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Apr 29, 2019

For U.S. healthcare leaders, trusted data is more important than ever, as their organizations migrate from the fee-for-service model to value-based care. During this transition, healthcare organizations must weigh investments, risks, and trade-offs objectively with quantitative, trustworthy data.

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Apr 24, 2019

The vast majority of endotoxin tests for pharmaceuticals and medical devices, as well as their in-process intermediates and raw materials, are microplate-based. They require tedious reconstitution and dilution steps for preparation of Control Standard Endotoxin (CSE) dilutions and Positive Product C...

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Apr 24, 2019

For many reasons from ease of administration to dosing accuracy to manufacturing efficiency pharmaceutical manufacturers prefer to formulate their APIs as solid dosage drugs, and particularly tablets. There is significant room, however, for improvement of tableting processes. Advances in tableting t...

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Apr 22, 2019

Digital transformation does not stop at the pharmaceutical industry. But until Pharma 4.0 can become socially acceptable, it will first and foremost be necessary to define globally uniform standards. This is going to take time. Time which the industry does not have in view of the speed of developmen...

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Apr 22, 2019

Efforts to ease patient burden with multi-API products and the increasing number of candidate products with low bioavailability are creating opportunities for contract manufacturing and development organizations (CDMOs) to create value with innovative, but complex, finished dosage formulations. Prov...

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Apr 18, 2019

Approximately half of all marketed drugs are administered orally, mostly in solid forms such as tablets or capsules. However, many APIs suffer from poor water solubility which leads to slow dissolution rates in the gastrointestinal tract and poor oral bioavailability. Hot melt extrusion is an effici...

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Apr 17, 2019

A more personalized approach to medicine can save lives and reduce medication-related side effects.

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Apr 16, 2019

The use of aqueous cleaning in pharmaceutical manufacturing can provide numerous benefi ts in terms of effectiveness, minimal surface residue, and easier cleaning validation. Virtually any pharmaceutical manufacturing equipment — from tablet presses to a stainless steel mixing tanks — ca...

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Apr 16, 2019

Over the past decade, the healthcare ecosystem has slowly moved toward the “triple aim”: better healthcare experiences, improved outcomes, and a slowing of the growth of overall healthcare costs. While many pharma companies have focused on educating and engaging patients to promote share...

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Apr 10, 2019

To better predict the future of HIV pharmaceuticals, we must understand the past – that’s the premise behind Horizons in HIV Drug Development – What’s Past is Prologue, the free whitepaper from Citeline, part of the Informa Pharma Intelligence suite of industry intelligence s...

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Apr 10, 2019

As pharmaceutical companies move increasingly toward changing production methods from batch to continuous processing, there is a need to re-evaluate the types and formulations of the excipients used. Within a continuous process, conventional monofunctional excipients must be added through individual...

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Apr 10, 2019

Rising drug spending and increased desire for expenditure controls are consistent themes across the US, Europe, and emerging markets. With governments and private healthcare systems under increasing pressure to fund high-cost, innovative therapies, which often launch with limited clinical trial evid...

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Apr 09, 2019

The social, demographic and economic context in which the pharmaceutical industry (Pharma) operates is changing dramatically, as we noted in “Pharma 2020: The vision”.

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Apr 04, 2019

The social, demographic and economic context in which the pharmaceutical industry (Pharma) operates is changing dramatically, as we noted in “Pharma 2020: The vision”, the White Paper PricewaterhouseCoopers* published in June 2007 (see sidebar, Seven major trends reshaping the pharmaceut...

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Apr 04, 2019

Lipids play a structural role in organisms, forming cells and organelles’ membranes. Due to their implication in widespread pathologies such as cancer or inflammation, they are gaining considerable interest within the scientific community.

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Apr 03, 2019

Herewith ACD/Labs presents their web-based software solution to the multiple challenges experienced in screening workflows; offering effective support for high-throughput catalyst screening.

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Apr 02, 2019

The FDA’s cGMPs for the 21st Century: A Risk-Based Approach Initiative In early 2002, the Food and Drug Administration (FDA) announced their Pharmaceutical cGMPs for the 21st Century: A Risk-Based Approach initiative. According to the FDA position paper: “The FDA oversees the quality of ...

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Mar 31, 2019

Drug manufacturing is a multifaceted undertaking in which numerous parallel processes, activities and resources must be marshaled and reconciled within a high-pressure environment where human errors inevitably occur.

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Mar 27, 2019

A period of market exclusivity is critical for most novel pharmaceutical products and the duration of that exclusivity has a direct impact on the value of a pharmaceutical asset. There several forms of exclusivity that can apply to pharmaceutical products. This overview is a summary of one of them: ...

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Mar 21, 2019

Following on from our review of trends in the current pharmaceutical R&D pipeline, published in March 2019 this supplement takes a look at the industry’s success stories of 2018 – the drugs which were launched on to the market for the first time during the year. Our survey focuses ex...

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Mar 21, 2019

Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum.

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Mar 20, 2019

Pharmaceutical companies aiming to develop innovative new therapies and treatments face many challenges. Without proper processes and systems in place, it is very difficult to replicate successful results, mitigate failures, reduce product variability and ultimately deliver a new therapy to market. ...

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Mar 15, 2019

This whitepaper aims to provide pharmaceutical researchers with a better understanding of the uses and benefits of hybrid silica-based supports in HPLC separations of drug compounds. In a quick, absorbing read that includes commentary from a number of experts in the field, readers can find out how h...

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Mar 14, 2019

How slow-motion trends are driving biopharma growth, the dangerous impact of unproven stem cell therapies and more. For over two decades, the biopharmaceutical manufacturing industry has created a body of industrial knowledge and institutional experience.

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Mar 12, 2019

The pathophysiology of neurological disease and injury is admittedly highly complex and temporally dynamic. This poses a daunting challenge for the development and appropriate use of physiologically relevant models for investigative research. Subtle fluctuations occur continually, and degenerative p...

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Mar 12, 2019

It’s all too easy for pharmaceutical processes to slow marketing campaigns, rendering them unmanageable and ineffective, but a ground-breaking initiative is proving that digital content delivery can be timely, effective and drive a return-on-investment.

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Mar 11, 2019

Drug development and production are challenging, however, high throughput characterization systems can greatly accelerate discovery programs. Using a proprietary discovery and development platform technology, Avitide enables its partners to rapidly advance candidate molecules to the clinic and achie...

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Mar 11, 2019

Our understanding of tumor biology is constantly evolving and helps to shed new light on the behavior of many cancers as well as providing new pharmacological targets and treatment strategies. Over the past decade, there have been immense technological advances in the field of in vitro translational...

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Mar 10, 2019

When different drug products are produced in shared facilities, the potential for cross-contamination is always a concern that needs to be addressed.

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Mar 09, 2019

In recent years, cancer immunotherapies, in particular, immune checkpoint blockade and combination therapies, have demonstrated remarkable success in treating multiple refractory cancers. One such therapeutic approach prevents T cell exhaustion by blocking the PD-1/PD-L1 pathway, which has shown tum...

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Feb 27, 2019

Once deemed an “experts-only” approach to chemical synthesis, flow chemistry is a cost-efficient technique growing in popularity that can increase safety and flexibility and improve product quality. However, not all chemical profiles perform better under flow conditions. Thus, you must k...

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Feb 26, 2019

The healthcare industry is facing major demographic changes that will dramatically impact which services are needed and how they are delivered. As Millennials, Generation X, and Baby Boomers enter new life stages at the same time, there are simultaneous demands for lower cost, convenient care and be...

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Feb 20, 2019

While there are many perspectives and publications on the “Hospital of the Future,” few, if any, provide a system perspective. Too often, when imagining the Health System of the Future, a hospital-centric model emerges. The challenge in this hospital-centric view is that it ignores most ...

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Feb 20, 2019

When it comes to clinical supplies, the journey is every bit as important as the destination. And these days, the journey of clinical supplies to investigator sites is becoming costlier and more complex, much like the global trials for which the materials are bound. The price of failure is high. A s...

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Feb 20, 2019

The pharmaceutical marketplace is undergoing huge changes, as we indicated in “Pharma 2020: The vision”, the White Paper PricewaterhouseCoopers* published in June 2007.1 These changes will have a major bearing on the kind of business models pharmaceutical companies need to employ. Most B...

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Feb 18, 2019

Recently, rapid advancements have been made in molecular testing technology for infectious diseases. This white paper briefly reviews those advances and discusses the choices laboratory managers face in light of them. We focus on flexible-content syndromic panels for respiratory, gastrointestinal, a...

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Feb 18, 2019

The monitoring of biotechnological fermentation processes, used for the production of modern biopharmaceutical drugs, is becoming ever more relevant for the promotion of economic production, particularly within the manufacturing sector. Up until now, biotechnical techniques have typically been monit...

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Feb 18, 2019

Maintaining the integrity of a drug during a pharmaceutical manufacturing scale-up isn’t always an easy feat, but it’s essential for producers who wish to grow their operation while ensuring high standards and legal compliance.

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Feb 15, 2019

Pharma R&D Annual Review 2019 is based on the stats and data from Pharmaprojects, part of Informa’s Citeline family of intelligence solutions. Authored for the 27th time by Ian Lloyd, Senior Director, Pharmaprojects, this whitepaper contains the whole nine yards.

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Feb 13, 2019

Discover what strategies healthcare organizations are undertaking to address the top issues that face them: addressing cost pressures resulting from declining reimbursements and improving the patient experience. Learn about the steps necessary to address these issues and become an intelligent enterp...

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Feb 12, 2019

Since the inception of electronic health record (EHR) systems, volumes of patient data have been collected, creating an atmosphere suitable for translating data into actionable intelligence. The growing field of artificial intelligence (AI) has created new technology that can tackle large data sets,...

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Feb 12, 2019

Adhesives are indispensable in the automotive, aeronautic, and medical industries, among others. Modern adhesives are complex, and their quality requires an assessment of initial components as well as the final product. Molecular spectroscopy approaches, including FTIR and Raman, can be used to iden...

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Feb 12, 2019

The incidences of pharmacy fraud involving pharmaceutical manufacturers’ co-pay card programs are on the rise. In this white paper, TrialCard discusses the steps it has taken to expand its Pharmacy Fraud Monitoring service, which identifies fraud and greatly reduces the reimbursement funds tha...

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Feb 11, 2019

Depending on your point of view, red blood cells, or erythrocytes, are throwaways and a nuisance, ruining a good blood specimen if the cells burst and contaminate the sample. On the other hand, erythrocytes have significant value in specific types of research, and if your objective is biobanking the...

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Feb 04, 2019

Twenty years ago, there was a shift in pain management, and it became more common to prescribe opioids for chronic pain. Initially, physicians were misinformed that addiction tothese medications was highly unlikely in a clinical setting, causing a shift towards prescribing opioids as the drug class ...

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Feb 04, 2019

This whitepaper explores how best in class anatomy, physiology and clinical content, images and customised solutions enable organizations to achieve strong competitive advantage, drive credibility, productivity and differentiation. We will share ideas that you can consistently apply to your own orga...

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Feb 01, 2019

Whilst commonly used air displacement pipettes are highly accurate for most liquid dispensing applications, the viscosity, volatility, surface tension and temperature of the solution can adversely affect their performance. In pharmaceutical formulations, frequently used liquids, like glycerol, are m...

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Jan 31, 2019

Cellular heterogeneity plays a critical role in systems and pathologies, but many genomic analysis techniques derive their findings from multicellular samples, potentially burying key information from individual cells or rare subsets. Next-generation sequencing-based single-cell whole transcriptome ...

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Jan 28, 2019

A wide variety of polymer types are available to the DDCP developer,and many are available on the market that meet the necessaryregulatory requirements. Careful consideration should be given tothe choice of vendor to ensure that quality and consistency aremet. The available polymers span a wide rang...

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Jan 25, 2019

Artificial intelligence helps pharma companies find patients for clinical trials. While AI can be used to make sense of clinical trials data, another use of artificial intelligence in the pharmaceutical industry is to find the patients to take them.

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Jan 25, 2019

Finite Element Analysis (FEA) has been widely used to analyze the in vivo structural response of implantable medical devices and assess device performance, reliability and durability. In order to obtain a robust design, parameter variations and their influence on device performance need to be unders...

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Jan 21, 2019

Patient satisfaction is currently treated as one proxy for the quality of care a patient receives. Admittedly subjective, satisfaction survey scores are nonetheless put to all kinds of concrete purposes, from reimbursement to performance pay. While satisfaction scores undoubtedly help gauge the expe...

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Jan 18, 2019

ON DRUGS AND DRUG U. BY TAKING THE: 2019. National Drug. & Alcohol. IQ Challenge.

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Jan 17, 2019

Animal toxins present a major threat to human health worldwide, predominantly through snakebite envenomings, which are responsible for over 100,000 deaths each year. To date, the only available treatment against snakebite envenoming is plasma-derived antivenom. However, despite being key to limiting...

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Jan 15, 2019

Crystallization of active pharmaceutical ingredients (API) and related pre- and early formulation development play critical roles in successful drug development and manufacturing. The associated challenges can create significant roadblocks in the production of APIs and drug products as well as compl...

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Jan 14, 2019

Drug company rebates and discounts have always been an opaque aspect of the US pharma industry. There is little transparency in how much drug companies pay in rebates and discounts. Indications are it is annually in the tens of billions of dollars for the industry and growing. Price concessions can ...

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Jan 14, 2019

Sterile transfer of components and other materials between sterile and non-sterile areas has always been a major concern in the pharmaceutical production industry. Previously, injectables and other medicinal products were produced in conventional clean rooms with insufficient protective barrier syst...

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Jan 13, 2019

Orphan drugs (ODs) for rare diseases (RDs) present pharma companies with the opportunity to address a substantial unmet medical need, with approximately 7,000 RDs, and only about 5% having effective treatments. A large number of patients in the US are affected with these RDs (around 25-30 million pe...

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Jan 11, 2019

GABAA receptors represent a large and complex family of ion channels that consist of at least 16 subunits (α1-6, β1-3, γ1-3, δ, ε, π, θ) and have been shown to be vital for the normal functioning of the brain. These ligand-gated chloride ion channels form pent...

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Jan 10, 2019

15 minutes. That’s how long your doctor has to see you, assess your complaint, diagnose a solution and see you out the door hopefully on the pathway back to wellness. This isn’t much time when you consider the wealth of information that he or she has to consider. Your patient record, the...

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Jan 10, 2019

For decades medical devices have been standalone instruments that interacted only with the patient or medical provider. The advent of technological innovations including miniaturization, low power computation, and wireless technologies has created a new paradigm in the healthcare industry: the Inter...

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Jan 08, 2019

In this white paper, it will be demonstrated that the use of three HILIC phases, which provide very different and complementary selectivity to one another, is both practical and effective for HILIC method development. These selectivity differences can be exploited, together with mobile phase pH, to ...

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Jan 07, 2019

The pharmaceutical sector is at a crossroads. In a heavily disrupted marketplace, characterized by shifting payer attitudes and patient empowerment, neither incremental adjustments nor steady evolution are likely to halt the decline of the traditional pharmaceutical business model. This paper looks ...

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Jan 05, 2019

In this paper, you will learn how far we have come in generating massive amounts of patient data, but how unprepared we are to make use of it. A digital twin promises an outcome-driven approach to handling the data deluge arising from the patient’s interconnected biology, provider interactions...

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Jan 04, 2019

Large molecule discovery and development is a complex series of interwoven cycles that span many teams within a research and development organization. By making a commitment to informatics, Amgen pioneered the shift to large molecules and was on the forefront of addressing the complexity of large mo...

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Jan 04, 2019

The dates are confirmed, the syllabus completed and the course directors are ready to welcome you to the only MBA carefully developed for pharmaceutical leaders: the MBA Pharmaceutical Management.

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Jan 04, 2019

Checkpoint inhibitors in bladder cancer, combination regimens in renal cell carcinoma (RCC) and novel anti-androgens in early prostate cancer treatment lines have demonstrated patient benefit, increasing survival times and addressing major areas of unmet need. However, payers are concerned about the...

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Jan 02, 2019

The quality and efficacy of drugs depends significantly on their proper packaging: Sterile products and moisture / oxygen sensitive drugs require excellent sealing throughout the shelf life of the product (up to a few years) in order to protect it from biological contamination and the ingress of wat...

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Jan 01, 2019

AIM’s Clinical Appropriateness Guidelines (hereinafter “AIM’s Clinical Appropriateness Guidelines” or the “Guidelines”) are designed to assist providers in making the most appropriate treatment decision for a specific clinical condition for an individual. As used ...

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Dec 28, 2018

Intouch’s annual trends report highlights the healthcare and tech trends that will shape the year ahead. You can look back and see our predictions for 2018, 2017, and 2016. And if you do, you might think — wait! Some of these trends look familiar from previous years! If so — you&rs...

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Dec 27, 2018

Quantifying the direct and indirect value that a business unit delivers to its parent health system has traditionally been difficult. In this case study, we discuss the impact of pharmacy customer loyalty on the Fairview Health Services system, and we introduce a new, data-driven methodology for mea...

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Dec 26, 2018

Scientific interest in rare disease drug discovery has been growing exponentially and the number of new therapies targeting rare and orphan diseases has doubled in the past 6 years. In this white paper, we have reviewed innovative approaches to develop successful therapies for rare diseases such as ...

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Dec 26, 2018

Monoclonal antibody (mAb) therapeutics have been widely used to treat various diseases, including cancer. Oftentimes, dimers and other high molecular weight aggregates are present in the mAb therapeutics, leading to reduced biological activity. Traditionally-used methods for aggregate removal rely h...

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Dec 26, 2018

Cloud computing represents an IT service model which helps in the delivery of computing services, both hardware and software, to customers, on demand, over a network, which utilizes the internet. Thus, users only incur operating expenses associated with the time and length of usage, and are not requ...

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Dec 15, 2018

IT departments in large healthcare institutions face numerous challenges. They are expected to help implement new initiatives to improve patient care, oftentimes while having to support legacy applications that may have been cobbled together over many years. At the same time, they must follow ever-s...

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Dec 14, 2018

Accenture commissioned a seven-country survey of 7,905 consumers aged 18+ to assess their attitudes toward healthcare technology, modernization and service innovation. The online survey included consumers across seven countries: Australia (1,031), England (1,043), Finland (848), Norway (768), Singap...

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Dec 12, 2018

The most essential requirement to enable the ability to move forward with confidence on a population health strategy is a solid foundation of data and information that is connected, complete, accurate, and available in real time. The rapid digitization of health data of all types ensures that data w...

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Dec 12, 2018

Sterility testing of final drug products is a mandatory release test for pharmaceutical companies and is critical to ensure patient safety. However, traditional methods such as membrane filtration require a minimum incubation time of 14 days. This long time to result in delays in product release and...

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Dec 11, 2018

Development and production of biopharmaceuticals are complex. Even minor impurities, orchanges in attributes such as glycosylation or charge heterogeneity, can have a profound impact on the safety and = ef cacy of the nal product. Traditionally, multiple analytical techniques have been required to ...

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Dec 11, 2018

According to a recent report from the Tufts Center for the Study of Drug Development, the total price tag for bringing a new drug to market can be up to $2.7 billion.1 While development costs are high, keeping costs low during commercial production while delivering products that are safe for human u...

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Dec 10, 2018

The genome has given clinical researchers a powerful tool for understanding the biological foundations of many diseases, but it only tells part of the story. This ebook shows how different laboratories are employing mass spectrometry and other cutting-edge tools to collect richer datasets based on a...

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Dec 05, 2018

Before placing a medical device on the European market, manufacturers need to produce technical documentation providing evidence of conformity with the relevant legislation. Technical documentation needs to be in compliance with the Medical Devices Directive (MDD) 93/42/EEC or the Active Implantable...

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Dec 05, 2018

Whether decoding Data Matrix symbols, reading text with Optical Character Recognition (OCR), or performing product inspection with machine vision, Industrielle Sensorsysteme Wichmann (ISW) GmbH has been meeting demanding applications with high-performance, turnkey automation solutions for over 20 ye...

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Nov 30, 2018

Gene therapy, the modification of genetic information in living cells to address a mutated gene, has the ability to dramatically change the way diseases are treated, or even cured. First conceptualized in the early 1970s, the seminal paper on the subject was published in Science by Theodore Friedman...

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Nov 30, 2018

The phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase Akt is a vital signaling cascade involved in cell survival, progression and thus causes various types of cancers. Various kinase inhibitors targeting PI3K/Akt have been extensively studied but promising results could not be obt...

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Nov 29, 2018

Airflow visualization testing, conducted as part of a routine review program, can help assure that aseptic filling areas remain under a state of proper control. In fact, ISO standards recommend frequent airflow measurements. ISO standard 14644-2 requires “specifications for testing and monitor...

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Nov 28, 2018

Biologics development and manufacturing is inherently complex and challenging. Compounding this is the added pressure to be first to market in a highly competitive healthcare landscape, where delays can put the success of a product and company at risk. The implication for process development enginee...

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Nov 28, 2018

The analysis of all incoming pharmaceutical raw materials is key part of 21CFR compliance. It is therefore important to have a high-throughput method by which raw materials may be analyzed, while also preventing sample exposure. This application note explores the analysis and identification of vario...

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Nov 26, 2018

Tissue pathology is at the core of various aspects of the pharmaceutic pipeline. Digital pathology is a technology that converts glass microscope slides with tissue samples into whole slide digital images, which can be used to identify, quantify, and document key characteristics of tissue samples. T...

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Nov 25, 2018

Alzheimer’s disease (AD) is one of the most common multifactorial diseases, including a range of abnormal cellular/molecular processes occurring in different regions of the brain. This disease is considered to be a major contributor to dementia in elderly people. The pathophysiology involves t...

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Nov 22, 2018

The briefing note at hand has been prepared to annotate with further conceptual clarity the structure and organization of the Framework for Action, with the objective of specifying the following: its strategic vision according to the determinants of people-centered health services; how needed transf...

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Nov 22, 2018

AI has the potential to provide huge benefits to the pharmaceutical industry, from improving R&D productivity through to more effective sales representative deployment and better supply chain management. Adoption of AI is lagging other sectors, with initial forays mainly being led by big pharma ...

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Nov 21, 2018

The EU Medical Devices Regulation 2017/745 (MDR) has significantly increased the burden of compliance and potential legal liability exposure for economic operators, including EU authorized representatives (ARs) of manufacturers established outside of the European Economic Area (EEA), Switzerland and...

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Nov 19, 2018

The US health industry has often lagged other industries—think tech, retail, hospitality when it comes to modernizing. Once thought to operate outside the greater US economy, the industry with its byzantine payment system, complicated regulatory barriers, and reliance on face-to-face interacti...

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Nov 18, 2018

Lentiviruses are single-stranded RNA viruses and the second major subgroup of the retroviruses. Lentiviruses are powerful tools in molecular biology. They have long incubation periods and are capable of delivering relatively large loads of genetic information into the DNA of a broad range of cells w...

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Nov 17, 2018

Less than a hundred years ago diabetes was a death warrant. The discovery of insulin in The 1920s was a major breakthrough. Since then, thanks to the dedicated work of scientists, researchers, doctors, and nurses in this country and abroad, there have been huge strides forward in our knowledge of di...

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Nov 16, 2018

Drug discovery is undergoing a transformation powered by advances that provide more knowledge from biological assays, allow for screening orders of magnitude more molecules and enable smarter selection of compounds. We are on the cusp of having previously unimaginable amounts of information about ea...

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Nov 15, 2018

Tablet hardness testing plays an important role in pharmaceutical product development and quality control. In the race to streamline tablet hardness analysis, Advantest combines speed, simplicity and increased the precision with innovative and non-destructive terahertz (THz) metrology.

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Nov 14, 2018

Metabolomics is an emerging field of “omics” concerned with measuring and interpreting the metabolic state (i.e. metabolome) and is an essential technology for defining the key functional attributes of tumors or cancer cells.

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Nov 13, 2018

In this study, the Toxtyper is used for drug screening in drug consumption rooms which are seen as an important element to minimize drug-related health problems (e.g. infection risk) and promote contact of drug users with employees of drug help programs.

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Nov 13, 2018

How advances in imaging technology and the use of artificial intelligence and analytics are improving the accuracy and cost of medical imaging for early cancer diagnosis, and increasing confidence in vital preventive screening programs.

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Nov 12, 2018

Data protection regulations define how an individual’s personal information can be used by organizations, businesses, and government. These regulations also contain safeguards that seek to ensure healthcare data is not susceptible to attack, misuse or misappropriation. As most know, misusing a...

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Nov 12, 2018

Technology for People shows the way to an exciting future where healthcare technology is designed by humans, for humans, to create positive change that can transform healthcare organizations and society.Digital breakthroughs are enabling healthcare enterprises to improve labor productivity, clinical...

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Nov 12, 2018

Immortality has long been treated as a work of fiction - a trait only possessed by mythological Gods and divine creatures. Is there an afterlife or life after death? Each religion or system of belief had its own way to deal with such questions. Certain scientists and philosophers, writers have theor...

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Nov 12, 2018

This white paper outlines the philosophy, methods, and deliverables for the PhUSE Computational Sciences Symposium Emerging Trends and Technology working group project “Clinical Trials Data as RDF.” The project was formed to investigate the feasibility of using Linked Data as a future-pr...

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Nov 10, 2018

Pharmaceuticals play a prominent role worldwide. This widespread presence is met with regulatory requirements at each phase of pharmaceutical development and manufacturing—from inspection of raw materials to quality control of final products. Consistently producing pharmaceuticals that both co...

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Nov 10, 2018

What matters most when building and sustaining a healthcare organization? What are the precise levers to pull to promote physician well being, financial success, and better outcomes at lower cost? To answer these questions, Athena health launched an ongoing research project in 2016. Now in its secon...

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Nov 08, 2018

The landscape of clinical trials continues to evolve over time as scientific breakthroughs and technological innovations emerge, which continue to be tracked by assessing recently initiated trials through Trialtrove’s annual Clinical Trials Roundup.

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Nov 08, 2018

On October 12, 2017, through Executive Order 13813, you directed the Administration, to the extent consistent with the law, to facilitate the development and operation of a health care system that provides high-quality care at affordable prices for the American people by promoting choice and competi...

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Nov 07, 2018

Robust safety and tolerability data are essential in cancer therapeutic studies, and some trials are specifically designed with a key objective of demonstrating improved safety and tolerability. The development of a clinical trial framework and data elements to demonstrate comparative safety and tol...

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Nov 06, 2018

Across the country, hearing health is becoming a hot topic of conversation and it’s grabbing the attention of the organizations that deliver health care benefits to millions of Americans. Driving this phenomenon are several wide-ranging factors as shown below.

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Nov 05, 2018

This white paper represents a key piece of research into the potential benefits of mobile working in healthcare and considers the obstacles that will have to be surmounted along the way. Given our research was conducted in the aftermath of last May’s WannaCry attack, it will come as little sur...

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Nov 05, 2018

Depression affects approximately 1 in 6 Americans, with 10 – 30% of depression patients becoming treatment-resistant. Find out what the pipeline looks like for depression and what the emerging strategies in this area are in Depression: New Insights Shifting the Treatment Paradigm.

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Nov 02, 2018

Mobile value chain revenues in the US grew 10 percent per annum from 2009 to 2014, and profits rose by as much as 15 percent. The year 2015 is expected to see 3 percent growth in revenues and 6 percent growth in profits.

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Nov 02, 2018

The Center for Connected Health Policy’s (CCHP) Fall 2018 release of its report on “State Telehealth Laws and Reimbursement Policies” offers policymakers, health advocates, and other interested health care professionals a freshly redesigned summary guide of telehealth-related polic...

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Nov 02, 2018

As the pharmaceutical industry continues to look for new and innovative ways to treat disease, some companies are putting more focus on how to prevent them. Vaccine development, while a long and complex process, has the potential to save millions of lives globally, especially in low-income countries...

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Nov 02, 2018

A Nutanix enterprise cloud reduces the cost and complexity of IT infrastructure for healthcare while improving scaling, availability, and data protection. Conventional infrastructure is no longer able to address healthcare challenges, such as regulatory hurdles, resource constraints, highly mobile w...

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Oct 30, 2018

Raman spectroscopy has taken large strides in recent years as more Raman vendors have developed handheld Raman units capable of carrying out raw material identification or verification. Raman spectroscopy is used as a fingerprinting tool to capture the unique Raman spectrum of each raw material. The...

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Oct 30, 2018

Follow-on drugs, also referred to as ‘next-generation drugs’, are ‘an established practice’ among drug innovators. They are one of the most effective R&D strategies implemented by drug innovators, and can be considered a cannibalization or switching strategy. In a nutshel...

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Oct 25, 2018

The FDA has a number of regulatory routes through which a company can seek approval for a generic drug. The most notable is the Abbreviated New Drug Application (ANDA) route whereby a generic company develops an exact copy of the innovator product and can use the safety and efficacy data from the in...

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Oct 22, 2018

This white paper explores a number of ways that today’s modern, laboratory-based PXRD instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high quality, stable products and accelerate their speed to market. All applications described and ...

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Oct 19, 2018

Facing increasing margin pressures—and having already implemented many proven cost reduction and revenue-increasing measures—hospitals and health systems have to find new ways of reducing their costs without compromising quality or patient safety. By drawing on the expertise of their pha...

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Oct 19, 2018

Although previous regulation of prescription drug advertising has come from the U.S. Food and Drug Administration (FDA), this proposal comes from the Centers for Medicare & Medicaid Services (CMS).

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Oct 18, 2018

As Informa Pharma Intelligence has done for the past three years, this analysis examines the landscape of industry-sponsored clinical trials completed during 2017, of which there were a total of 3,534 Phase I through Phase III/IV. The nearly 700 trials terminated in 2017 were not included in this an...

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Oct 15, 2018

This white paper outlines the main benefits of using hard radiation for material analysis studies. X-ray powder diffractometers are generally equipped with X-ray sources using Cu anodes. For specific applications, however, switching to shorter wavelength, ‘harder’ radiation, like obtaine...

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Oct 12, 2018

There are many different requirements with which in vitro diagnostic manufacturers must comply in order to place the product on the market. At the core of most of these requirements is a fundamental need to have a good quality management system (QMS) in place. This is certainly not a new requirement...

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Oct 12, 2018

Make the most of BIO-Europe 2018 with essential partnering information from Informa Pharma Intelligence. Our insightful whitepaper, Pharma Partnering Trends Revealed: 2018 Edition, contains critical information on the landscape for biotech partnerships and is now available for you to download &ndash...

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Oct 03, 2018

In the end, you need to be rewarding your sales reps with more than just money if you want to keep them motivated and if you want your sales compensation plan to deliver on its promises.

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Oct 03, 2018

The first CRM launch truly changed the way sales were managed. We went from tracking customers on spreadsheets (and even in rolodexes) to tracking them and their attendant opportunities with software. It wasn’t long before reps started to feel the purpose of a CRM was more about preserving the...

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Oct 03, 2018

Let’s explore some of the current processes around pipeline management and forecasting and how they can be improved.

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Oct 02, 2018

Chromatography resins used for the production of biopharmaceuticals need to be cleaned efficiently to ensure the safety and efficacy of the bioproduct. Impurities that are not removed can build up on the chromatography column and start to leach into the process material in subsequent cycles. Efficie...

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Sep 28, 2018

Countless studies and articles have confirmed that connected medical devices from implantable products like pacemakers to diagnostic devices such as CT scanners and more are indeed vulnerable to malicious exploitation. This paper offers both technical and nontechnical solutions to help prevent and m...

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Sep 27, 2018

Even before the 1980s, the notion of attaching a cytotoxic agent to a tumorspecific antibody captured the collective imagination of the international drug development community. Were antibodydrug conjugates (ADCs) the magic bullets everyone was looking for that could, among other things, cure cancer...

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Sep 27, 2018

A thorough knowledge of an active pharmaceutical ingredient’s (API) solid state behavior is essential for reliable drug product manufacturing, patent protection, and formulation viability. This article discusses various aspects of the API in the solid state which can impact pharmaceutical prod...

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Sep 26, 2018

High-throughput sequencing technologies have revolutionized the field of human genetics, allowing researchers to more easily investigate and understand biological processes and their impact. Using these technologies, researchers can analyze entire genomes or specific targeted regions of interest, wi...

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Sep 24, 2018

Experts have asserted that despite recent developments, pharmaceutical supply chains are still far from reaching their full technological potential. Blockchain holds significant promise to advance the digital strength of medicine supply.

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Sep 21, 2018

In this white paper, we review a successful small molecule drug discovery project conducted by a team of scientists from Genentech and Charles River that spanned hit identification and lead optimization of a highly potent LRRK2 inhibitor.

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Sep 21, 2018

While the outlook for medical device companies appears positive, unsustainable health care costs and new competitive forces threaten to alter the future industry landscape. If today’s manufacturers fail to stake their claim in the evolving value chain, they risk being caught in the middle and ...

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Sep 19, 2018

CIO’s and IT professionals in healthcare organizations are tasked with achieving a balance between the demand for universal access to information and the need to ensure security. In particular, four critical challenges these organizations face in terms of striking this balance include the foll...

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Sep 18, 2018

Has anyone asked you, "What is your laboratory capacity?" In the scientific world of planning laboratories, defining capacity is not so straightforward. This makes answering the question challenging unless you have a method in place. The reality is, you have options for measuring your labo...

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Sep 18, 2018

The era of precision medicine has arrived, and with it, a tidal wave of data from disparate sources, including electronic health records (EHRs), lab systems, pathology, and genomics. By integrating data from all available sources and analyzing it in smart ways, clinicians can finally get a complete ...

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Sep 17, 2018

If you’ve ever bought a car, remodeled a room in your home, or shopping for a high-end TV, chances are the business you purchased from offered you a financing plan. The appeal of financing is simple: it helps people buy things they normally couldn’t afford. Financing is a convenient solu...

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Sep 16, 2018

To promote sustainable development, the smart city implies a global vision that merges artificial intelligence, big data, decision making, information and communication technology (ICT), and the internet-of-things (IoT). The aging issue is an aspect that researchers, companies, andthe government sho...

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Sep 16, 2018

Anemia is a frequent complication of critical care, with up to 90% of ICU (Intensive Care Unit) patients being anemic by their third day in the ICU1. Anemia is associated with poor patient outcomes, especially amongst those patients with cardiovascular disease2345. The treatments of choice for anemi...

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Sep 15, 2018

The healthcare IT landscape continues to change. One minute you’re convinced the world is round and then a series of new technological advancements, entrants into the market, and mergers and acquisitions give it the appearance of being flat. Then news breaks and it becomes a Rubik’s cube...

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Sep 15, 2018

The publication of the stable text of the European Union (EU) Medical Devices Regulation (MDR), and the In Vitro Diagnostic Medical Devices Regulation (IVDR), in June 2016 documented political agreement between the three EU Institutions – the Commission, the Parliament, and the Council –...

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Sep 10, 2018

With over 10 million new cases worldwide each year and approximately 1.7 million deaths, tuberculosis (TB) is one of the leading global threats to human health. While disease detection and control methods have yielded a steady decline in the number of deaths attributable to TB, the emergence of mult...

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Sep 09, 2018

When you experience the choreography of tens of thousands of face-to-face meetings at BIO-Europe®, you know for certain that partnering is still the deal in the biotech industry. From nearly 1,000 partnering booths, executives from across the industry value chain pitch assets, exchange ideas, an...

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Sep 06, 2018

When discussing the success of a drug therapy, a common topic amongst biopharmaceutical companies is data quality and data integrity; what the challenges are and what the key elements are to ensuring that the latest discovery is patentable, does not result in re-conducting critical research or devel...

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Aug 28, 2018

Unlike well-defined chemical medicinal products and their generic counterparts, biologics and their biosimilar counterparts employ sophisticated bioprocessing technologies that utilize living systems for their manufacture. Because these complex heterogeneous protein molecules are produced in living ...

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Aug 27, 2018

Pervading every facet of daily life, the information superhighway that society has come to know and love – and occasionally loathe – has enabled a level of communication, collaboration, insight, and analysis that has rendered the current generation of smartphone-addicted kindergarten cod...

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Aug 24, 2018

Liquid chromatography is a technique of key importance for many areas of chemical analysis and one that has evolved with the progression of technology and instrumentation over time. Here we highlight some of the key similarities and differences between high-performance liquid chromatography (HPLC) a...

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Aug 22, 2018

Fifty-one percent of national survey respondents say they’ve had a contact center strategy in place 3 – 5 years, and 48 percent call their strategy an enterprise transformation initiative. Can maximizing this resource take your hospital into the future? See what your peers are saying abo...

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Aug 21, 2018

Over the years, studies have been conducted to ascertain the cost of research and development (“R&D”) required to bring a new drug to market. Experts disagree on the exact amount, but the consensus is that the figure is in the hundreds of millions to over a billion dollars. Pharmaceu...

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Aug 18, 2018

The healthcare industry has never been more focused on data its promise and its pitfalls as it is today. From slashing health care spending to detecting fraud or coordinating care across multiple providers improved the use of healthcare data has been held up as a “silver bullet” to slay ...

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Aug 15, 2018

The patient experience is the sum of all the interactions had with a healthcare organization. Therefore, the experience itself hasn't confined to the walls of a hospital or the examination rooms of an outpatient clinic the experience starts anywhere and anytime the patient first encounters the h...

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Aug 12, 2018

Cloud computing is having a profound impact on healthcare. The healthcare cloud computing market is projected to almost triple between 2015 and 2020 to $9.48 billion.1 In the same time period, the Internet of Things (IoT) the number of devices connected to the Internet is projected to double to 40.9...

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Aug 10, 2018

Want to improve the reliability of your neuronal cell culture experiments by increasing the survival of the neurons? This white paper shows how the B-27 Plus Neuronal Culture System increases neuron survival and improves maturation and neural network activity.

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Aug 08, 2018

Transitional care encompasses a broad range of services and environments designed to promote the safe and timely passage of patients between levels of health care, across care settings, and among various providers. Care settings can include a range of points of care such as hospitals, long-term care...

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Aug 08, 2018

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the k...

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Aug 08, 2018

DNAtix intends to create a future ecosystem for Genetics where consumers, researchers, laboratories, and clinics operate making Genetics more accessible, transparent and anonymous. DNAtix intends to offer cutting-edge Genetics and Blockchain services which intend to be anonymous and encrypted and in...

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Aug 08, 2018

30 years ago, polymerase chain reaction (PCR) burst onto the scene and steadily became one of the most common procedures in the lab. Advanced technologies have made it possible to achieve more accurate copies in a fraction of the time, no matter which of the several PCR-based methods you use. PCR is...

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Aug 03, 2018

The aim of this white paper is to demonstrate how GE Healthcare Life Sciences single-use products can be applied in the field of vaccine manufacturing. The white paper includes a brief discussion on modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream pr...

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Jul 30, 2018

Artificial Intelligence (AI) is seeing another spring and becoming a ubiquitous part of society. Researchers and engineers have made important steps towards solving practical problems in machine learning, particularly in such applications as vision, speech, machine translation, and decision making.

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Jul 24, 2018

The collection and analysis of data generated outside of restricted clinical trials are now critical to pharma companies. Data gathered in the routine delivery of healthcare can be mined to uncover insights into treatment efficacies and outcomes in the real world. Such insights, known as real-world ...

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Jul 23, 2018

Custom ICM solutions are built for you, not auditors, so they typically don’t offer visibility into actions performed over time. Auditors may lack confidence in your homegrown system, especially if they find errors or omissions. In fact, audit risk from errors and overpayments is often the mos...

whitepaper

Jul 23, 2018

It all ties together. You want your sales reps to behave a certain way and close a certain amount of deals in specific verticals that match your company’s 3- and/or 5-year vision, but the systems you currently have in place to drive this behavior are not working for any number of reasons. Most...

whitepaper

Jul 23, 2018

You’ve reached a certain point in the evolution of your company and you know it’s time to invest in a CPQ system. But buyer beware: There’s a certain misconception around CPQ systems as being plug-in devices or turnkey-ready overlays of your existing infrastructure, or a simple app...

whitepaper

Jul 23, 2018

The spreadsheet conundrum... Joe Smith, sales director for Great Start-Up Number 5 Billion and Thirty-One, puts on a blindfold and reaches out blindly for something, ANYTHING, to help him organize his team’s deals and commissions. He’s hopeful. He’s waiting. He knows he’ll co...

whitepaper

Jul 17, 2018

Quickly and easily quantitate immune checkpoint markers using a fraction of the sample volume required by traditional ELISA. In this technical note, we show how AlphaLISA can be used to detect and quantify additional immune checkpoint molecules within the PBMC population with and without activation ...

whitepaper

Jul 14, 2018

The publication of the stable text of the European Union (EU) Medical Devices Regulation, and the In Vitro Diagnostic Medical Devices Regulation in June 2016 documents the political agreement between the three EU Institutions – the Commission, the Parliament and the Council – on the cont...

whitepaper

Jul 12, 2018

Alzheimer’s Disease (AD) is the most common form of dementia and accounts for 60% to 80% of dementia cases. In this progressive disease, dementia symptoms gradually worsen over a number of years. Memory loss is mild during the early stages, but individuals with late-stage Alzheimer's lose ...

whitepaper

Jul 11, 2018

This whitepaper explains how you can find ways to optimize the holistic preclinical development process. When it comes to informatics and data management, each preclinical domain is characterized by specific requirements due to their diverse scientific needs. This whitepaper explains how you can fin...

whitepaper

Jul 07, 2018

For the 14th year in a row, AHRQ is reporting on health care quality and disparities. The annual National Healthcare Quality and Disparities Report (QDR) is mandated by Congress to provide a comprehensive overview of the quality of health care received by the general U.S. population and disparities ...

whitepaper

Jul 07, 2018

Technological advancements occur with such frequency that it’s challenging to stay on top — or ahead — of the Next Big Thing, but successful businesses need to focus attention on advancements that make internal processes easier and more efficient. Highly successful businesses take ...

whitepaper

Jul 06, 2018

See results from the Tufts eClinical Landscape Study – CRO Report on current data management practices, goals, and challenges for contract research organizations (CROs). Findings include. Anticipated growth and variety of data sources used by CROs. CROs’ biggest challenges with clinical ...

whitepaper

Jul 05, 2018

As the cloud becomes more prevalent, healthcare leaders are finding themselves in a multi-cloud environment, moving beyond basic infrastructure on demand to strategic innovations such as running real-time data analytics for the management of chronic disease patients.

whitepaper

Jun 29, 2018

More Americans are concerned about health care costs (85%) that are concerned about other common worries like retirement (73%), housing (66%), and child care (49%).1 While Republicans, Democrats, and independents are divided over many healthcare issues, everyone agrees that the top health care prior...

whitepaper

Jun 26, 2018

Bridging the gap from discovery to verification and validation requires high-performing instruments and software as well as competency in mass spec-based biomarker discovery and method development for biomarker verification. The Thermo Scientific™ Q Exactive™ HF-X mass spectrometer rises...

whitepaper

Jun 23, 2018

Unauthorized diversion and falsification of drug products createsafety risks in the supply chain, creating life-threatening risk for patients and reducing revenue, profitability and brand equity for drug owners. To reduce the proliferation of counterfeit drugs in the U.S., the Drug Quality and Secur...

whitepaper

Jun 19, 2018

The incorporation of mortality data into healthcare data sets allows fraud prevention, accurate billing, and benefits distribution, and true outcome analysis (especially in fatal disease areas like oncology, where survival is a key endpoint). The net effect of adding mortality data is strengthening ...

whitepaper

Jun 19, 2018

Accurate patient matching is becoming 10 times more challenging and 10 times more critical. Instantly and dramatically improve your EHR’s or EMPI’s patient matching without disrupting any of its core functionality. By injecting the power of Referential Matching, you will get the full val...

whitepaper

Jun 18, 2018

For immuno-oncology research and the hunt for new immunotherapies, scientists are required to reliably quantify the functions and interactions of cancer cells and immune cells. Cell proliferation assays of tumor growth are a mainstay. Activation and proliferation assays for immune cells are also use...

whitepaper

Jun 16, 2018

Employer medical cost trend has plateaued. While the predictability is a welcome change from the wild swings and peak double-digit trends in the 2000s, steady as she goes is not good enough. Medical costs continue to grow as a percent of total employee compensation, making even the current trend uns...

whitepaper

Jun 15, 2018

The following situation is typical for many production plants: After a routine quality check, the production process is stopped or an already produced batch is suspended because the analysis results were not within the relevant critical values. But does the tested product really deviate from the spe...

whitepaper

Jun 15, 2018

The views expressed by authors or editors do not necessarily represent the decisions or the stated policies of the European Observatory on Health Systems and Policies or any of its partners. The designations employed and the presentation of the material in this publication do not imply the expressio...

whitepaper

Jun 12, 2018

From passive consumer to active participant, the role of the patient is changing as dramatically as the healthcare system itself. The fee-for-service, volume-based care of the past is giving way to a value-based care system focusing on quality and outcomes. The newsystem seeks to reduce skyrocketing...

whitepaper

Jun 10, 2018

Pharmaceutical or biotechnology companies looking to outsource their API production are planning for success by looking at the entire development cycle. The growing desire to select one API partner to work with throughout the drug development process, and to potentially also synthesize commercial qu...

whitepaper

Jun 06, 2018

Healthcare providers need to rethink their current patient payment collections strategy, thanks to two recent phenomena: high-deductible plans that are shifting a greater portion of the bill to the patient, and an increase in the number of patients struggling to pay those higher bills.

whitepaper

Jun 06, 2018

The World Health Statistics series is WHO’s annual compilation of health statistics for its 194 Member States. The series is produced by the WHO Department of Information, Evidence, and Research, of the Health Metrics and Measurement Cluster, in collaboration with all relevant WHO technical de...

whitepaper

Jun 06, 2018

The aim of this White Paper is to identify inequalities in government policies towards opioids that contribute to the inadequate treatment of pain. It calls for their replacement with policies that will support doctors and patients in their efforts to relieve pain.

whitepaper

Jun 06, 2018

The number of therapeutic antibodies entering the market continues to grow annually, with 2017 seeing ten approvals in either the European Union or the United States supported by a robust late-stage clinical pipeline that will likely yield even more approved drugs in 2018 and 2019. Making a drug is ...

whitepaper

Jun 05, 2018

Ever participated in one of those benchmarking exercises? You know what I mean. When a (usually) fresh-faced consultant asks lots of questions and fills in a spreadsheet comparing what you do with your competitors. Well, beware. Trying to copy and follow others in a world of turbulence and massive u...

whitepaper

Jun 05, 2018

When choosing an EMR system, you need to consider what you will be charged for and when, in addition to how much. This highly visual guide offers a clear explanation of how various pricing models work, along with actual pricing for popular EMR and Practice Management software packages.

whitepaper

Jun 05, 2018

Millennials are quickly becoming the dominant health care consumers, both for themselves, their families and as caregivers. Having grown up in a technology-first environment, however, they are increasingly dissatisfied with the static nature of health care options and are seeking out alternatives. N...

whitepaper

May 25, 2018

The number of users and devices requesting access to applications is growing exponentially, and enterprises are scrambling to adapt their authentication and authorization infrastructure to deal with this fast growth. REST APIs are a critical new application access channel. In a sense, REST APIs are ...

whitepaper

May 22, 2018

According to a recent study conducted by AmericanEHR, nearly 40 percent of physicians would not recommend their EHR solution to another provider; only slightly fewer said they would not purchase the same software again. Conversely, a study conducted this year by an EHR vendor, the approximately 60 p...

whitepaper

May 19, 2018

This guide outlines some simple strategies and tips for improving communication with your patients. Research indicates that ‘soft skills’ have a direct bearing on patient perceptions of the value of care provided, the degree of trust placed in the dentist and the success of treatment. Al...

whitepaper

May 17, 2018

There are many parenteral dosage forms from which the pharmaceutical scientist can choose to develop their drug product. For primary pack choices, there are traditional vials, ampoules, cartridges, pre-filled syringes and complex containers such as the various types of dual chamber syringes. Additio...

whitepaper

May 16, 2018

With breakthroughs in molecular engineering and antibody humanization, monoclonal antibodies (Mab) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders, and infectious disease. Most therapeutic a...

whitepaper

May 16, 2018

The information set forth below may not be exhaustive and does not imply any elements of a contractual relationship. While we make every effort to ensure that any material in this whitepaper is accurate and up to date, such as products, services, technical architecture, token distribution, company t...

whitepaper

May 15, 2018

Manufacturing of sterile aqueous suspensions requires the thorough understanding of the factors that influence their physical and chemical stability. Particle morphology of the active pharmaceutical ingredient (API) plays a key factor in drug product dissolution rate, resuspendability, and syringeab...

whitepaper

May 15, 2018

Citeline’s Pharmaprojects’ Pharma R&D Annual Review 2018 is here! Tune into expert insights and score illuminating data on the trends that affected pharmaceutical R&D throughout 2017 and continue to shape the market today – for free.

whitepaper

May 15, 2018

By making use of external resources that assist in developing, implementing, and maintaining high-quality physician advisor programs, hospitals can improve their financial performance and ensure that patients receive the most appropriate care for their medical needs.

whitepaper

May 10, 2018

Truven Health Analytics™ offers a full suite of digital marketing and engagement services and support for healthcare organizations. These services range from email list management and execution; to multilayered, multimodal, lead nurturing campaigns; to fully automated patient engagement messag...

whitepaper

May 09, 2018

The MDR is significantly more comprehensive and detailed compared to the MDD. While the MDD comprises 23 Articles and 12 annexes over 60 pages, the MDR has 123 articles and 17 annexes over 175 pages. This table presents a summary of the provisions of some of the articles of the MDD and MDR together ...

whitepaper

May 06, 2018

Selecting the right site is the single most crucial decisionyou’ll make about your next clinical trial. And perhaps thesingle most important consideration in selecting a site iswhether it can make its enrollment. Many don’t; in fact,20-25 percent of all clinical studies close because the...

whitepaper

May 05, 2018

Commonwealth Physicians (Commonwealth)* is a physician-owned multi-specialty, the multi-location practice that serves more than 500,000 patients and is comprised of 25 practices and nearly 100 primary care providers. For Commonwealth Physicians, the Affordable Care Act (ACA) created the impetus for ...

whitepaper

May 05, 2018

Transitioning patients between outpatient, inpatient, post-acute and home settings can be a major challenge for hospitals. For organizations participating in value-based reimbursement models, it can also be costly. This case study examines how Holyoke (Mass.) Medical Center redesigned its care manag...

whitepaper

May 05, 2018

One of the best ways to maximize revenue under value-based care arrangements is for health plans and physicians to team up and work collaboratively on health care transformation. By building a strong and meaningful partnership, health plans and physicians can achieve higher quality, provider better ...

whitepaper

May 04, 2018

Supplier Relationship Management (SRM) is not a new concept, but it has been growing in importance. The theory is that SRM helps enterprises drive value in both recessionary periods – like that of the last few years – by enabling cost reductions, and also in high growth phases by support...

whitepaper

May 02, 2018

The pharmaceutical industry is acutely aware that the future of health and care, particularly in the United States, are trending toward a digital revolution. The importance of successfully executing a digital health strategy, as well as creating new financial models and partnerships, cannot be under...

whitepaper

May 01, 2018

Many healthcare organizations depend on the work of financial counselors to help patients understand both their insurance coverage and their financial obligations. These professionals help patients make smart choices by answering questions about the cost of healthcare services, setting up payment pl...

whitepaper

Apr 30, 2018

Accurate benchmarking has never been more important to the biopharma industry than now, with increased scrutiny related to development costs at an all-time high. What benchmarks are you using? How does your development program compare to those of your competitors? Explore the importance of benchmark...

whitepaper

Apr 30, 2018

Over the last decade, it is undeniable that China has emerged as a rising star in pharmaceutical R&D, with a rich pipeline of new drugs and robust clinical trial activities

whitepaper

Apr 25, 2018

Automated image analysis systems that provide detailed morphological information are rapidly replacing manual microscopy as the most effective method of characterizing both particle shape and size. These sophisticated new instruments use the latest technology to provide useful and actionable insight...

whitepaper

Apr 24, 2018

The recent changes to the United States Pharmacopeia (USP) regarding requirements for elemental impurity testing has peaked interest into new ways to perform this testing. Combining these new requirements with the introduction of USP chapter <735> X-ray fluorescence spectrometry1 permits a new...

whitepaper

Apr 19, 2018

As plastics continue to enter the environment, understanding their global impact is vital to addressing microplastic pollution. Since its emergence as an environmental and potential human health threat, researchers have strived to develop tools for accurately measuring microplastics in environmental...

whitepaper

Apr 06, 2018

With the prevalence of asthma and chronic obstructive pulmonary disease (COPD) growing worldwide, the availability of primary human cells from these respiratory diseases is critical to increasing research and knowledge about the disease at a cellular level. In this study, we sought to identify genes...

whitepaper

Apr 05, 2018

Preventable chronic diseases such as diabetes, cardiovascular disease, and cancers are responsible for over 40 of the 56 million annual deaths worldwide (7 out of every 10 deaths). Our medical communities spend vast resources battling complications of these behavior-related conditions, despite the a...

whitepaper

Apr 05, 2018

Don't miss out on this comprehensive review of all the presentations from the conference, compiled by our analysts, with key points and expert insight, for you to download, for free. A full list of events and catalysts that were announced or updated during the conference is included in this repo...

whitepaper

Apr 04, 2018

There is currently a half-dozen different insulin analogues on the market. These differ from each other and from natural insulin by just a few amino acids but exhibit markedly different pharmacokinetic and pharmacodynamic properties. Liquid chromatography and mass spectrometry (LC-MS) offers a power...

whitepaper

Mar 28, 2018

RNA sequencing (referred to as RNA-Seq with traditional sequencing technologies) has led to unprecedented advances in all fields of biology and medicine. It has been an invaluable tool for the study of human genetics and the pathology associated with the disease. Transcript isoform expression and us...

whitepaper

Mar 22, 2018

Download this white paper, which looks at novel biologics in development for the treatment of uncontrolled, eosinophilic asthma and whether they can fulfill the promise of truly targeted therapies for one of the most prevalent respiratory diseases worldwide. Novel Biologics for Asthma: Steps on the ...

whitepaper

Mar 21, 2018

In recent years the pharmaceutical industry has faced declining R&D productivity, a rapidly changing healthcare landscape and fierce competition from generics resulting in lower growth and profit margins. Historically, drug development focused on clinical trials management and outcomes. Now howe...

whitepaper

Mar 20, 2018

Aqueous cleaners are typically formulated to ensure maximal cleaning performance by using key ingredients such as surface active agents (surfactants) excellent wetting agents that allow the cleaning solution to penetrate into crevices while getting under soils to allow for removal. Often very dilute...

whitepaper

Mar 16, 2018

Chronic pain, the kind of pain a person wakes up with every morning and goes to sleep with every night, has a standard of care that is often incomplete and sometimes inaccurate. Chronic pain treatment often revolves around drug therapy and managing side effects without addressing non-drug therapies ...

whitepaper

Mar 14, 2018

While the co-rotating, intermeshing TSE is more commonly used in pharmaceutical R&D and production, the counter-rotating, intermeshing TSE is a viable tool to successfully process these formulations. Energy input must be strategically balanced to perform mixing functions without degradation of A...

whitepaper

Mar 14, 2018

By partnering with Patheon, you have access to a remarkable range of dosage form technologies for oral solids. Take advantage of our expansive scientific resources and expertise to create a product that stands out in the marketplace. For more information about specific dosage forms, as well as where...

whitepaper

Mar 13, 2018

A major step towards personalized medicine was achieved in early 2014 when the first report of sequencing a human genome for $1,000 was announced—hailed by some as one of the greatest scientific and medical achievements of the last decade.

whitepaper

Mar 10, 2018

Top Country Involvement in Ongoing Oncology PGX Trials. Emerging Trend: Epigenetics. Unexpected Advantages and Potential Pitfalls of Using PGX Selection. Top Sponsors of Ongoing or Planned Oncology Trials. What's on the Horizon for Pharmacogenetics and Epigenetics in Drug Development

whitepaper

Mar 10, 2018

This paper will discuss the aspects of bioburden reduction in a manufacturing area or cleanroom during operational shutdown or for routine maintenance scheduling. Relevant regulatory requirements are overviewed, along with the factors constituting aseptic cleaning. What is aseptic cleaning? Asepsis ...

whitepaper

Mar 07, 2018

Pharmaceutical companies face many challenges in Japan in terms of it's complex regulatory and pricing process. Regular price cuts also pose hurdles for the introduction of new innovative drugs. Despite these challenges, the world’s second largest pharmaceutical market presents a number of...

whitepaper

Mar 01, 2018

About Clinical Research Management, Inc. Clinical Research Management (ClinicalRM) is not only involved in the testing of new antibiotics in Phase I, II, III studies, monitoring protocol development, site selection, and assistance with FDA approvals, but is also involved in responding to the challen...

whitepaper

Feb 27, 2018

Maintaining specific levels of cleanliness in controlled environments is extremely difficult. It’s even more difficult when an assortment of cleaning tools are utilized. Standard operating procedures become unnecessarily complex and difficult to meet. Cleaning becomes cumbersome, and the resul...

whitepaper

Feb 26, 2018

How can I trust my data? This is a common concern for many researchers using particle measurement instrumentation. Is the data affected in any way by the measurement technology, or alternatively by the user during sample preparation or by the analysis parameters employed? To answer this question we ...

whitepaper

Feb 22, 2018

Screening is an essential method for analyzing a group of chemicals, molecules, and/or compounds for a particular function in a prescribed assay. Proper screening is important for the identification of meaningful associations between compounds and targets, and screening technology has significantly ...

whitepaper

Feb 21, 2018

Despite a recent global economic downturn, the world pharmaceutical market is currently estimated to be valued at around $300 billion and rising, according to the World Health Organization (WHO). In a recent post, the WHO states that more than a third of the market is controlled by 10 large drug com...

whitepaper

Feb 18, 2018

What if we could focus interventions on the exact group that can be most impacted? Target those that can benefit most from a particular series of actions? Identify transient patients so they could be intensely targeted before they move on? Effectively manage high-risk patients to reduce costs? This ...

whitepaper

Feb 18, 2018

At first, users had to remember different passwords for each application, and provisioning and managing accounts was a cumbersome, manual IT task. In addition, compliance with the Health Insurance Portability and Accountability Act (HIPAA) in Heal’s mobile, 100% cloud environment would require...

whitepaper

Feb 17, 2018

At Digital Health, we provide unparalleled insight into the world of NHS IT. It is little wonder that, in recent years, an increasing amount of our work has centered on the use of mobile technology in healthcare. As smartphones and tablets haverevolutionized our day-to-day lives, so too do they seem...

whitepaper

Feb 14, 2018

Patients are increasingly behaving like consumers in a healthcare setting. As a result, they expect enhanced services and experiences when engaging with providers and health systems. How can health systems engage patients in an integrated effort that aligns with strategic goals to improve patient ou...

whitepaper

Feb 13, 2018

The pharmaceutical industry is not short of challenges patent cliffs, regulatory scrutiny, and R&D productivity, as well as a complex supply chain. Pharmaceutical products see several changes of hands from the manufacturers to distributors to dispensers and, finally, the patients allowing easy e...

whitepaper

Feb 09, 2018

The mature mammalian central nervous system (CNS) is composed of three major differentiated cell types: neurons, astrocytes, and oligodendrocytes. Neurons transmit information through action potentials and neurotransmitters to other neurons, muscle cells or gland cells. Astrocytes and oligodendrocyt...

whitepaper

Feb 02, 2018

Healthcare providers face a variety of resource, compliance, security, cost, reimbursement, and integration challenges that have not only strained hospital IT departments but also have affected they way clinicians provide care

whitepaper

Jan 20, 2018

There are many parenteral dosage forms from which the pharmaceutical scientist can choose to develop their drug product. For primary pack choices, there are traditional vials, ampoules, cartridges, pre-filled syringes and complex containers such as the various types of dual chamber syringes.

whitepaper

Jan 10, 2018

This whitepaper addresses value-based health care as a driver of Population Health Management (PHM), the integral role of pharmacy-based Population Health Management, and strategies for optimizing patient care capacity to improve health outcomes and lower costs of patient care.

whitepaper

Jan 08, 2018

Learn how predictive data analytics can drive new breakthroughs, accelerate big data solutions, and derive insights from publicly available data with this eBook from The Scientist and PerkinElmer, Inc.Thanks to technology, scientific research can now generate more data than ever before. However, the...

whitepaper

Jan 07, 2018

Population health, value-based care, decreasing revenues, and increasing costs are just a few of the pivotal issues challenging healthcare IT leaders today. Among other requirements, these issues call for large amounts of data, real-time data access, scalable analytics platforms, and systems interop...

whitepaper

Jan 03, 2018

Will the 21st Century Cures Act further its aim to boost drug and device development in 2018? That's one of the questions the life sciences industry and attorneys are asking for the new year. The law provides extra money for research and development including ambitious research into cancer and a...

whitepaper

Dec 21, 2017

The Drug Supply Chain Security Act (DSCSA) has been on the mind of pharmaceutical manufacturers since it was enacted in 2013, and the latest requirements are rapidly approaching. Beginning in November 2017, manufacturers will be expected to mark their products with a National Drug Code (NDC), Serial...

whitepaper

Nov 23, 2017

The affordability of healthcare and biopharmaceutical drugs is a top concern for Americans. It is often asserted that promoting innovation and affordable drugs are conflicting goals. New innovations, however, often provide improved health that was not previously available at any price or obviate the...

whitepaper

Nov 22, 2017

The U.S. healthcare ecosystem has faced a myriad of changes in just the last decade, and pharmaceutical companies continue to face the effects of those changes. The players have become more diverse, and today’s target audience for pharmaceuticals has expanded to include healthcare organization...

whitepaper

Nov 01, 2017

Near-infrared (NIR) spectroscopy is an important technique for materials checking at various stages of the manufacturing process but is particularly useful at the raw materials inspection stage. Raw materials come in a variety of physical forms including liquids, gels, and solids, requiring a versat...

whitepaper

Oct 30, 2017

Medication errors remain an unnecessary public health menace. While industry awareness of the problem has existed for some time, efforts to reduce the incidence and impact of medication errors have not yet yielded much success. Consequently, the significant patient harm, death toll, and economic bur...

whitepaper

Oct 18, 2017

Since Haemophilus influenzae became the first organism to have its entire genome sequenced in 19951 , there are now thousands of completed genomes covering archaea, bacteria and eukarya. However, the term ‘completed genome’ (or sometimes ‘finished genome’) is overused, as the...

whitepaper

Oct 17, 2017

The fully realized vision of precision medicine includes the capability to rapidly diagnose, sequence and develop a personalized treatment plan based on combined analysis of genotype, phenotype, environmental, clinical and behavioral data. Precision medicine can be advanced through the “All of...

whitepaper

Oct 17, 2017

Management of medication delivery through lyophilization - freeze-drying - is a crucial enabling process technology for many important parenteral drugs. Close to 50% of biopharmaceuticals, including enzymes, proteins and monoclonal antibodies, must be lyophilized as these therapeutic agents are insu...

whitepaper

Oct 16, 2017

The Government and the Swedish Association of Local Authorities and Regions, together with a broad set of pharmaceutical actors, have agreed to continue to build on and enhance the work that has been in progress for several years under the National Pharmaceutical Strategy (NPS). There is a consensus...

whitepaper

Oct 09, 2017

Polymun offers the development of liposomal formulations for all kinds of pharmaceutically active ingredients and vaccine antigens. A broad spectrum of analytical methods has been established for this purpose. Polymun produces GMP material including all necessary documentation for IMPD/IND. We also ...

whitepaper

Oct 05, 2017

Pharmacometrics, which includes the science of pharmacokinetics-pharmacodynamics (PK-PD), is one of the most commonly misunderstood, misused, and under-appreciated resources available to drug developers. In the past PK-PD was an afterthought, but today it is required by regulators and here’s w...

whitepaper

Oct 05, 2017

The aim of this hospital-based retrospective analysis is to estimate the prevalence of Lysosomal Storage Disease (LSDs) in the Eastern Province of Saudi Arabia between 1983 and 2016. A total number of 89 Saudi patients from 43 families were diagnosed with different types of LSDs within this time per...

whitepaper

Sep 27, 2017

Healthcare information technology has quickly become one of a clinician’s most powerful instruments. The implementation of technology to automate the collection and documentation of patient information, such as vital signs, continues to expand to users in more care settings within the hospital...

whitepaper

Sep 21, 2017

BlockRx is a series of initiatives presented by iSolve, a privately owned Blockchain solution provider for the Life Sciences Industry. The mission of BlockRx is to interconnect systems that do not readily communicate, establish data provenance that satisfies regulatory and business requirements, and...

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Sep 20, 2017

Fascinating developments within the biopharmaceutical sector have been grabbing industry headlines for years now. The field is exciting and developing rapidly. However, the reality is that small, synthetic molecules remain critically important to both drug development pipelines and the market.

whitepaper

Sep 11, 2017

Life Sciences companies are attempting to improve complianceand manufacturing efficiency while they drive to grow revenueand margins. However, current market conditions are creatingsubstantial headwinds to attaining these targets. S

whitepaper

Sep 01, 2017

The Drug Supply Chain Security Act (DSCSA) has been on the mind of pharmaceutical manufacturers since it was enacted in 2013, and the latest requirements are rapidly approaching. Beginning in November 2017, manufacturers will be expected to mark their products with a National Drug Code (NDC), Serial...

whitepaper

Aug 29, 2017

A revolution is occurring in cancer treatment, based on new insights into the biology of cancer, and resulting in dozens of new drugs on the market or in the development pipeline. Many of these new drugs are “targeted” therapies that are tailored to the specific genetics and molecular pa...

whitepaper

Aug 23, 2017

The development of novel therapeutic products involves a complex network of internal departments and external partners. Different groups across Process Development organizations typically use a variety of approaches to capture, manage, analyze and report data. These can range from paper and Excel to...

whitepaper

Aug 01, 2017

This white paper arises out of the Pink Ribbon drugs funding & trials conference, held at the faculty of pharmaceutical medicine on 23 March 2017 (full programme provided on page 13-15). The general theme to emerge from the conference is that the UK would benefit from enhanced communication betw...

whitepaper

Jul 14, 2017

The presence of residual metal impurities during drug manufacturing has become a major issue in the pharmaceutical industry in recent years, prompting a wide amount of interest in solutions for their safe and efficient removal.

whitepaper

Jul 04, 2017

At Lipotype our expertise are lipids, lipid metabolism, lipid chemistry and lipidomics. Therefore, statistical analysis is always done with this knowledge as a basis. We treat lipids not as isolated entities but as a metabolic network with substructure and with their functions in mind. At Lipotype w...

whitepaper

Jun 21, 2017

Silicones are used in pharmaceutical applications as part of formulations, as well as during manufacturing and in packaging. The term ‘silicones’ encompasses a large number of compounds based on polydialkylsiloxanes. The most common are trimethylsilyloxy-terminated polydimethylsiloxanes....

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Jun 21, 2017

Outsourcing pharmacovigilance activities is a standard business practice in a continuously expanding market segment. In the past, outsourced safety services were limited due to concerns about confidentiality, data security, and liability in cases of regulatory non-compliance, which are all still imp...

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Jun 20, 2017

For the 2017 survey,the maximum sample size- the number of countries and territories with at least one FIP member organisation or candidate member organisation at the time of the survey.

whitepaper

Jun 20, 2017

Drug manufacturers currently do not have an effective way to securely, transparently, and rapidly track the provenance of drugs or to access the data required to combat counterfeit drug sales. (1) As a result, they are unable to decrease the time and cost it takes to bring life-saving drugs to marke...

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Jun 19, 2017

Oracle’s Clinical One Platform will enable pharmaceutical companies to manage every trial function from randomizing patient participants and collecting and analyzing data to tracking budgets and ensuring trial safety from a single user interface.

whitepaper

Jun 17, 2017

From 2015 to 2019, global healthcare spending is expected to increase by 4.3% annually. Along with growth, the sector is going through the significant transformation of its operating models and supply chains. These include three key developments: First, there are significant pressures from governmen...

whitepaper

Jun 14, 2017

The most eye-catching change in innovation for 2016 from the previous year was the fall in the number of new agents approved by the FDA, 22 for 2016 versus 41 and 45 in 2014 and 2015 respectively. Five agents being licensed at the end of 2015, plus the large number of complete response letters issue...

whitepaper

Jun 12, 2017

In the pharmaceutical environment, and especially in the research and development field, the quality of the medicine is a critical step as it is facing challenges with increased? demand from the regulatory affairs to improve the quality of a pharmaceutical drug product. In order to ensure its proper...

whitepaper

Jun 08, 2017

Manufacturers of pharmaceuticals, drug delivery systems, and biomedical devices have come under growing pressure to perform sensitive and accurate analytical studies to detect, identify, and quantify extractable and leachable compounds (E&Ls). E&Ls may be inherently toxic or may contaminate ...

whitepaper

Jun 01, 2017

Round-up of the 2015 debuts; Distribution of phases of unapproved drug trials per therapeutic area in 2015; Top 25 disease by trial count Top locations for unapproved drug trials starting in 2015; Average number of countries disclosed per trial across most active industry sponsors

whitepaper

May 22, 2017

Price gouging in the US pharmaceutical drug industry goes back more than three decades. In 1985 US Representative Henry Waxman, chair of the House Subcommittee on Health and the Environment, accused the pharmaceutical industry of “gouging the American public” with “outrageous&rdquo...